Concise review: Dendritic cell development in the context of the spleen microenvironment

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

The dendritic cell (DC) population in spleen comprises a mixture of cells including endogenous DC progenitors, DC precursors migrating in from blood and bone marrow, and DC in different states of differentiation and activation. A role for different microenvironments in supporting the dynamic development of murine DC of different types or lineages is considered here. Recent evidence for production of DC dependent on splenic stromal cells is reviewed in the light of evidence that cell production is dependent on cells comprising an endothelial niche in spleen. The possibility that self-renewing progenitors in spleen give rise to DC with tolerogenic or regulatory rather than immunostimulatory function is considered.

Original languageEnglish
Pages (from-to)2139-45
Number of pages7
JournalInternational Journal of Cell Cloning
Volume25
Issue number9
DOIs
Publication statusPublished - Sep 2007
Externally publishedYes

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Dendritic Cells
Spleen
Stromal Cells
Bone Marrow Cells
Stem Cells
Endothelial Cells
Population

Cite this

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title = "Concise review: Dendritic cell development in the context of the spleen microenvironment",
abstract = "The dendritic cell (DC) population in spleen comprises a mixture of cells including endogenous DC progenitors, DC precursors migrating in from blood and bone marrow, and DC in different states of differentiation and activation. A role for different microenvironments in supporting the dynamic development of murine DC of different types or lineages is considered here. Recent evidence for production of DC dependent on splenic stromal cells is reviewed in the light of evidence that cell production is dependent on cells comprising an endothelial niche in spleen. The possibility that self-renewing progenitors in spleen give rise to DC with tolerogenic or regulatory rather than immunostimulatory function is considered.",
author = "Tan, {Jonathan K H} and O'Neill, {Helen C}",
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Concise review : Dendritic cell development in the context of the spleen microenvironment. / Tan, Jonathan K H; O'Neill, Helen C.

In: International Journal of Cell Cloning, Vol. 25, No. 9, 09.2007, p. 2139-45.

Research output: Contribution to journalReview articleResearchpeer-review

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AU - O'Neill, Helen C

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AB - The dendritic cell (DC) population in spleen comprises a mixture of cells including endogenous DC progenitors, DC precursors migrating in from blood and bone marrow, and DC in different states of differentiation and activation. A role for different microenvironments in supporting the dynamic development of murine DC of different types or lineages is considered here. Recent evidence for production of DC dependent on splenic stromal cells is reviewed in the light of evidence that cell production is dependent on cells comprising an endothelial niche in spleen. The possibility that self-renewing progenitors in spleen give rise to DC with tolerogenic or regulatory rather than immunostimulatory function is considered.

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M3 - Review article

VL - 25

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EP - 2145

JO - International Journal of Cell Cloning

JF - International Journal of Cell Cloning

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