Compliance with a structured weight loss program is associated with reduced systolic blood pressure in obese patients with chronic kidney disease

Helen L. MacLaughlin, Pantelis A. Sarafidis, Sharlene A. Greenwood, Katrina L. Campbell, Wendy L. Hall, Iain C. Macdougall

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12 Citations (Scopus)

Abstract

Background The effectiveness of lifestyle-based weight loss programs in obese patients with chronic disease has not been widely studied. This study examined the effectiveness of a weight management program (WMP), and sought to determine factors associated with successful weight loss in obese patients with chronic kidney disease (CKD).MethodsIn this prospective cohort study, all patients with a body mass index (BMI) of 30 kg/m2 referred to our clinic from January 2005 to December 2008 and who commenced a structured WMP of an energy-reduced renal diet, exercise, and pharmacotherapy were included in the analyses. Changes in body weight and associated variables up to 24 months were assessed with intention-to-treat mixed linear models and predictors of weight loss were identified with multiple linear regression.ResultsOne hundred and thirty-five patients (56% male), of mean age 52.2 years and BMI 36.4 kg/m 2 commenced the WMP. Significant weight loss was achieved for all patients at 6, 12, 18, and 24 months. Weight loss at 12 months was predicted by compliance and age, but not by baseline BMI, blood pressure (BP), stage of CKD or pharmacotherapy use. Greater compliance was associated with decreased systolic BP, with no change in mean antihypertensive medication dose.ConclusionsSignificant weight loss was achieved, demonstrating the effectiveness of the WMP, and compliance with a structured program improved weight loss and systolic BP.

Original languageEnglish
Pages (from-to)1024-1029
Number of pages6
JournalAmerican Journal of Hypertension
Volume25
Issue number9
DOIs
Publication statusPublished - Sep 2012
Externally publishedYes

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Weight Reduction Programs
Chronic Renal Insufficiency
Weight Loss
Blood Pressure
Weights and Measures
Body Mass Index
Compliance
Linear Models
Drug Therapy
Body Weight Changes
Antihypertensive Agents
Life Style
Chronic Disease
Cohort Studies
Prospective Studies
Exercise
Diet
Kidney

Cite this

MacLaughlin, Helen L. ; Sarafidis, Pantelis A. ; Greenwood, Sharlene A. ; Campbell, Katrina L. ; Hall, Wendy L. ; Macdougall, Iain C. / Compliance with a structured weight loss program is associated with reduced systolic blood pressure in obese patients with chronic kidney disease. In: American Journal of Hypertension. 2012 ; Vol. 25, No. 9. pp. 1024-1029.
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abstract = "Background The effectiveness of lifestyle-based weight loss programs in obese patients with chronic disease has not been widely studied. This study examined the effectiveness of a weight management program (WMP), and sought to determine factors associated with successful weight loss in obese patients with chronic kidney disease (CKD).MethodsIn this prospective cohort study, all patients with a body mass index (BMI) of 30 kg/m2 referred to our clinic from January 2005 to December 2008 and who commenced a structured WMP of an energy-reduced renal diet, exercise, and pharmacotherapy were included in the analyses. Changes in body weight and associated variables up to 24 months were assessed with intention-to-treat mixed linear models and predictors of weight loss were identified with multiple linear regression.ResultsOne hundred and thirty-five patients (56{\%} male), of mean age 52.2 years and BMI 36.4 kg/m 2 commenced the WMP. Significant weight loss was achieved for all patients at 6, 12, 18, and 24 months. Weight loss at 12 months was predicted by compliance and age, but not by baseline BMI, blood pressure (BP), stage of CKD or pharmacotherapy use. Greater compliance was associated with decreased systolic BP, with no change in mean antihypertensive medication dose.ConclusionsSignificant weight loss was achieved, demonstrating the effectiveness of the WMP, and compliance with a structured program improved weight loss and systolic BP.",
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Compliance with a structured weight loss program is associated with reduced systolic blood pressure in obese patients with chronic kidney disease. / MacLaughlin, Helen L.; Sarafidis, Pantelis A.; Greenwood, Sharlene A.; Campbell, Katrina L.; Hall, Wendy L.; Macdougall, Iain C.

In: American Journal of Hypertension, Vol. 25, No. 9, 09.2012, p. 1024-1029.

Research output: Contribution to journalArticleResearchpeer-review

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N2 - Background The effectiveness of lifestyle-based weight loss programs in obese patients with chronic disease has not been widely studied. This study examined the effectiveness of a weight management program (WMP), and sought to determine factors associated with successful weight loss in obese patients with chronic kidney disease (CKD).MethodsIn this prospective cohort study, all patients with a body mass index (BMI) of 30 kg/m2 referred to our clinic from January 2005 to December 2008 and who commenced a structured WMP of an energy-reduced renal diet, exercise, and pharmacotherapy were included in the analyses. Changes in body weight and associated variables up to 24 months were assessed with intention-to-treat mixed linear models and predictors of weight loss were identified with multiple linear regression.ResultsOne hundred and thirty-five patients (56% male), of mean age 52.2 years and BMI 36.4 kg/m 2 commenced the WMP. Significant weight loss was achieved for all patients at 6, 12, 18, and 24 months. Weight loss at 12 months was predicted by compliance and age, but not by baseline BMI, blood pressure (BP), stage of CKD or pharmacotherapy use. Greater compliance was associated with decreased systolic BP, with no change in mean antihypertensive medication dose.ConclusionsSignificant weight loss was achieved, demonstrating the effectiveness of the WMP, and compliance with a structured program improved weight loss and systolic BP.

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