Comparison of spatial summation properties at different body sites

Maleea D Holbert, Ashley Pedler, Danny Camfermann, Daniel S Harvie

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

BACKGROUND AND AIMS: The nociceptive system appears to have evolved a range of protective characteristics that are of great interest in understanding both acute and chronic pain. Spatial summation is one important characteristic, whereby increasing area of a stimulus, or distance between multiple stimuli, results in more intense pain-not only greater area of pain. One of the mysteries of chronic pain is why spinal pain is so prevalent relative to pain at other sites. Since pathological tissue models have failed to fully explain spinal pain, we theorized that body region specific differences in sensory processing-such as a greater propensity for spatial summation-may help to explain its vulnerability. We aimed to examine this by comparing the properties of summation at different body parts: the dorsal forearm, neck, and back.

METHODS: Spatial summation of pain was investigated using noxious intra-dermal electrical stimuli in healthy pain-free adults (14 males, 6 females), and the perceived pain intensity was rated on a 0-100 pain scale. Area-based stimulation was investigated by doubling the stimulation area with the addition of a second electrode placed adjacent to the first. Distance-based summation was investigated by randomly varying the separation distance between paired noxious electrical stimuli at separations of 0, 10, 15, and 20cm.

RESULTS: This study demonstrated that the properties of area- and distance-based summation are uniform across the neck, back, and forearm in healthy adults. Spatial summation of pain was also found to be greatest at 15- and 20-cm paired separations for all body regions tested, confirming that noxious information can be integrated over an extensive anatomical area.

CONCLUSION: Data from this investigation refutes the thesis that spatial summation of pain may be a contributing factor for the reported difference in chronicity rates between spinal and peripheral sites. It remains, however, a potentially important mechanism by which noxious inputs from multi-level pathology might integrate and contribute to pain.

IMPLICATIONS: While data from this project suggest that there are no regional differences in the properties of spatial summation of noxious stimuli, regional differences in other characteristics of the nociceptive system may yet provide insight into why some spinal pain is so highly prevalent; nociceptive distance-based summation may be highly relevant where two or more conditions co-exist in close proximity.

Original languageEnglish
Pages (from-to)126-131
Number of pages6
JournalScandinavian Journal of Pain
Volume17
DOIs
Publication statusPublished - 9 Aug 2017
Externally publishedYes

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Pain
Body Regions
Forearm
Chronic Pain
Neck
Acute Pain
Human Body
Electrodes
Pathology
Skin

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Holbert, Maleea D ; Pedler, Ashley ; Camfermann, Danny ; Harvie, Daniel S. / Comparison of spatial summation properties at different body sites. In: Scandinavian Journal of Pain. 2017 ; Vol. 17. pp. 126-131.
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abstract = "BACKGROUND AND AIMS: The nociceptive system appears to have evolved a range of protective characteristics that are of great interest in understanding both acute and chronic pain. Spatial summation is one important characteristic, whereby increasing area of a stimulus, or distance between multiple stimuli, results in more intense pain-not only greater area of pain. One of the mysteries of chronic pain is why spinal pain is so prevalent relative to pain at other sites. Since pathological tissue models have failed to fully explain spinal pain, we theorized that body region specific differences in sensory processing-such as a greater propensity for spatial summation-may help to explain its vulnerability. We aimed to examine this by comparing the properties of summation at different body parts: the dorsal forearm, neck, and back.METHODS: Spatial summation of pain was investigated using noxious intra-dermal electrical stimuli in healthy pain-free adults (14 males, 6 females), and the perceived pain intensity was rated on a 0-100 pain scale. Area-based stimulation was investigated by doubling the stimulation area with the addition of a second electrode placed adjacent to the first. Distance-based summation was investigated by randomly varying the separation distance between paired noxious electrical stimuli at separations of 0, 10, 15, and 20cm.RESULTS: This study demonstrated that the properties of area- and distance-based summation are uniform across the neck, back, and forearm in healthy adults. Spatial summation of pain was also found to be greatest at 15- and 20-cm paired separations for all body regions tested, confirming that noxious information can be integrated over an extensive anatomical area.CONCLUSION: Data from this investigation refutes the thesis that spatial summation of pain may be a contributing factor for the reported difference in chronicity rates between spinal and peripheral sites. It remains, however, a potentially important mechanism by which noxious inputs from multi-level pathology might integrate and contribute to pain.IMPLICATIONS: While data from this project suggest that there are no regional differences in the properties of spatial summation of noxious stimuli, regional differences in other characteristics of the nociceptive system may yet provide insight into why some spinal pain is so highly prevalent; nociceptive distance-based summation may be highly relevant where two or more conditions co-exist in close proximity.",
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Comparison of spatial summation properties at different body sites. / Holbert, Maleea D; Pedler, Ashley; Camfermann, Danny; Harvie, Daniel S.

In: Scandinavian Journal of Pain, Vol. 17, 09.08.2017, p. 126-131.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Holbert, Maleea D

AU - Pedler, Ashley

AU - Camfermann, Danny

AU - Harvie, Daniel S

N1 - Copyright © 2017 Scandinavian Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

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