Abstract
derived from neuraminic acid, also known as 5-amino-3,5-dideoxy-Dglycero-D-galactonon-2-ulosonic
acid (a 9‑carbon monosaccharaide
containing a keto group at position C2 (ketononose)). The two most
common sialic acids are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic
acid (Neu5Gc). Sialic acids naturally reside on the
surface of most eukaryotic cells and soluble proteins, and can exist in
the free or bound form, in the second case typically bound to the
terminal end of glycoproteins and glycolipid oligosaccharides. The
human biological pathways are able to synthesise Neu5Ac, and although
Neu5Gc has been found in cases of certain cancers or severe
inflammatory diseases, it cannot be endogenously synthesised due to an
evolutionarily acquired gene mutation
| Language | English |
|---|---|
| Pages | 130-133 |
| Number of pages | 4 |
| Journal | Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences |
| Volume | 1104 |
| DOIs | |
| Publication status | Published - 1 Jan 2019 |
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Combining versatility with cost-effectiveness: Determination of both free and bound sialic acids, N-acetylneuraminic and N-glycolylneuraminic in unprocessed bovine milk. / Levonis, Stephan M; Pittet, Julie; Pointon, Bethaney; Schweiker, Stephanie S.
In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, Vol. 1104, 01.01.2019, p. 130-133.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Combining versatility with cost-effectiveness: Determination of both free and bound sialic acids, N-acetylneuraminic and N-glycolylneuraminic in unprocessed bovine milk
AU - Levonis, Stephan M
AU - Pittet, Julie
AU - Pointon, Bethaney
AU - Schweiker, Stephanie S
PY - 2019/1/1
Y1 - 2019/1/1
N2 - [Extract] Sialic acids are a group of nine‑carbon monosaccharides structurallyderived from neuraminic acid, also known as 5-amino-3,5-dideoxy-Dglycero-D-galactonon-2-ulosonicacid (a 9‑carbon monosaccharaidecontaining a keto group at position C2 (ketononose)). The two mostcommon sialic acids are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminicacid (Neu5Gc). Sialic acids naturally reside on thesurface of most eukaryotic cells and soluble proteins, and can exist inthe free or bound form, in the second case typically bound to theterminal end of glycoproteins and glycolipid oligosaccharides. Thehuman biological pathways are able to synthesise Neu5Ac, and althoughNeu5Gc has been found in cases of certain cancers or severeinflammatory diseases, it cannot be endogenously synthesised due to anevolutionarily acquired gene mutation
AB - [Extract] Sialic acids are a group of nine‑carbon monosaccharides structurallyderived from neuraminic acid, also known as 5-amino-3,5-dideoxy-Dglycero-D-galactonon-2-ulosonicacid (a 9‑carbon monosaccharaidecontaining a keto group at position C2 (ketononose)). The two mostcommon sialic acids are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminicacid (Neu5Gc). Sialic acids naturally reside on thesurface of most eukaryotic cells and soluble proteins, and can exist inthe free or bound form, in the second case typically bound to theterminal end of glycoproteins and glycolipid oligosaccharides. Thehuman biological pathways are able to synthesise Neu5Ac, and althoughNeu5Gc has been found in cases of certain cancers or severeinflammatory diseases, it cannot be endogenously synthesised due to anevolutionarily acquired gene mutation
UR - http://www.scopus.com/inward/record.url?scp=85056774771&partnerID=8YFLogxK
U2 - 10.1016/j.jchromb.2018.11.019
DO - 10.1016/j.jchromb.2018.11.019
M3 - Article
VL - 1104
SP - 130
EP - 133
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
T2 - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
SN - 1570-0232
ER -