Combining versatility with cost-effectiveness: Determination of both free and bound sialic acids, N-acetylneuraminic and N-glycolylneuraminic in unprocessed bovine milk

Stephan M Levonis, Julie Pittet, Bethaney Pointon, Stephanie S Schweiker

Research output: Contribution to journalArticle

Abstract

[Extract] Sialic acids are a group of nine‑carbon monosaccharides structurally
derived from neuraminic acid, also known as 5-amino-3,5-dideoxy-Dglycero-D-galactonon-2-ulosonic
acid (a 9‑carbon monosaccharaide
containing a keto group at position C2 (ketononose)). The two most
common sialic acids are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic
acid (Neu5Gc). Sialic acids naturally reside on the
surface of most eukaryotic cells and soluble proteins, and can exist in
the free or bound form, in the second case typically bound to the
terminal end of glycoproteins and glycolipid oligosaccharides. The
human biological pathways are able to synthesise Neu5Ac, and although
Neu5Gc has been found in cases of certain cancers or severe
inflammatory diseases, it cannot be endogenously synthesised due to an
evolutionarily acquired gene mutation
LanguageEnglish
Pages130-133
Number of pages3
JournalJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume1104
DOIs
Publication statusPublished - 1 Jan 2019

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Sialic Acids
Cost effectiveness
Cost-Benefit Analysis
Milk
Carbon
Neuraminic Acids
Acids
Monosaccharides
Glycolipids
Eukaryotic Cells
N-Acetylneuraminic Acid
Oligosaccharides
Glycoproteins
Genes
Mutation
Neoplasms
Proteins

Cite this

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title = "Combining versatility with cost-effectiveness: Determination of both free and bound sialic acids, N-acetylneuraminic and N-glycolylneuraminic in unprocessed bovine milk",
abstract = "[Extract] Sialic acids are a group of nine‑carbon monosaccharides structurallyderived from neuraminic acid, also known as 5-amino-3,5-dideoxy-Dglycero-D-galactonon-2-ulosonicacid (a 9‑carbon monosaccharaidecontaining a keto group at position C2 (ketononose)). The two mostcommon sialic acids are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminicacid (Neu5Gc). Sialic acids naturally reside on thesurface of most eukaryotic cells and soluble proteins, and can exist inthe free or bound form, in the second case typically bound to theterminal end of glycoproteins and glycolipid oligosaccharides. Thehuman biological pathways are able to synthesise Neu5Ac, and althoughNeu5Gc has been found in cases of certain cancers or severeinflammatory diseases, it cannot be endogenously synthesised due to anevolutionarily acquired gene mutation",
author = "Levonis, {Stephan M} and Julie Pittet and Bethaney Pointon and Schweiker, {Stephanie S}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.jchromb.2018.11.019",
language = "English",
volume = "1104",
pages = "130--133",
journal = "Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences",
issn = "1570-0232",
publisher = "Elsevier",

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TY - JOUR

T1 - Combining versatility with cost-effectiveness: Determination of both free and bound sialic acids, N-acetylneuraminic and N-glycolylneuraminic in unprocessed bovine milk

AU - Levonis, Stephan M

AU - Pittet, Julie

AU - Pointon, Bethaney

AU - Schweiker, Stephanie S

PY - 2019/1/1

Y1 - 2019/1/1

N2 - [Extract] Sialic acids are a group of nine‑carbon monosaccharides structurallyderived from neuraminic acid, also known as 5-amino-3,5-dideoxy-Dglycero-D-galactonon-2-ulosonicacid (a 9‑carbon monosaccharaidecontaining a keto group at position C2 (ketononose)). The two mostcommon sialic acids are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminicacid (Neu5Gc). Sialic acids naturally reside on thesurface of most eukaryotic cells and soluble proteins, and can exist inthe free or bound form, in the second case typically bound to theterminal end of glycoproteins and glycolipid oligosaccharides. Thehuman biological pathways are able to synthesise Neu5Ac, and althoughNeu5Gc has been found in cases of certain cancers or severeinflammatory diseases, it cannot be endogenously synthesised due to anevolutionarily acquired gene mutation

AB - [Extract] Sialic acids are a group of nine‑carbon monosaccharides structurallyderived from neuraminic acid, also known as 5-amino-3,5-dideoxy-Dglycero-D-galactonon-2-ulosonicacid (a 9‑carbon monosaccharaidecontaining a keto group at position C2 (ketononose)). The two mostcommon sialic acids are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminicacid (Neu5Gc). Sialic acids naturally reside on thesurface of most eukaryotic cells and soluble proteins, and can exist inthe free or bound form, in the second case typically bound to theterminal end of glycoproteins and glycolipid oligosaccharides. Thehuman biological pathways are able to synthesise Neu5Ac, and althoughNeu5Gc has been found in cases of certain cancers or severeinflammatory diseases, it cannot be endogenously synthesised due to anevolutionarily acquired gene mutation

UR - https://www.sciencedirect.com/science/article/pii/S1570023218313369?dgcid=author

U2 - 10.1016/j.jchromb.2018.11.019

DO - 10.1016/j.jchromb.2018.11.019

M3 - Article

VL - 1104

SP - 130

EP - 133

JO - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

T2 - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

JF - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

SN - 1570-0232

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