Clinical outcomes of vitamin D deficiency and supplementation in cancer patients

Laisa Teleni, Jacqueline Baker, Bogda Koczwara, Michael G Kimlin, Euan Walpole, Kathy Tsai, Elizabeth A Isenring

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

Results of recent studies suggest that circulating levels of vitamin D may play an important role in cancer-specific outcomes. The present systematic review was undertaken to determine the prevalence of vitamin D deficiency (<25 nmol/L) and insufficiency (25-50 nmol/L) in cancer patients and to evaluate the association between circulating calcidiol (the indicator of vitamin D status) and clinical outcomes. A systematic search of original, peer-reviewed studies on calcidiol at cancer diagnosis, and throughout treatment and survival, was conducted yielding 4,706 studies. A total of 37 studies met the inclusion criteria for this review. Reported mean blood calcidiol levels ranged from 24.7 to 87.4 nmol/L, with up to 31% of patients identified as deficient and 67% as insufficient. The efficacy of cholecalciferol supplementation for raising the concentration of circulating calcidiol is unclear; standard supplement regimens of <1,000 IU D₃ /day may not be sufficient to maintain adequate concentrations or prevent decreasing calcidiol. Dose-response studies linking vitamin D status to musculoskeletal and survival outcomes in cancer patients are lacking.

Original languageEnglish
Pages (from-to)611-21
Number of pages11
JournalNutrition Reviews
Volume71
Issue number9
DOIs
Publication statusPublished - Sep 2013
Externally publishedYes

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Calcifediol
Vitamin D Deficiency
Vitamin D
Neoplasms
Survival
Cholecalciferol

Cite this

Teleni, L., Baker, J., Koczwara, B., Kimlin, M. G., Walpole, E., Tsai, K., & Isenring, E. A. (2013). Clinical outcomes of vitamin D deficiency and supplementation in cancer patients. Nutrition Reviews, 71(9), 611-21. https://doi.org/10.1111/nure.12047
Teleni, Laisa ; Baker, Jacqueline ; Koczwara, Bogda ; Kimlin, Michael G ; Walpole, Euan ; Tsai, Kathy ; Isenring, Elizabeth A. / Clinical outcomes of vitamin D deficiency and supplementation in cancer patients. In: Nutrition Reviews. 2013 ; Vol. 71, No. 9. pp. 611-21.
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Teleni, L, Baker, J, Koczwara, B, Kimlin, MG, Walpole, E, Tsai, K & Isenring, EA 2013, 'Clinical outcomes of vitamin D deficiency and supplementation in cancer patients' Nutrition Reviews, vol. 71, no. 9, pp. 611-21. https://doi.org/10.1111/nure.12047

Clinical outcomes of vitamin D deficiency and supplementation in cancer patients. / Teleni, Laisa; Baker, Jacqueline; Koczwara, Bogda; Kimlin, Michael G; Walpole, Euan; Tsai, Kathy; Isenring, Elizabeth A.

In: Nutrition Reviews, Vol. 71, No. 9, 09.2013, p. 611-21.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Isenring, Elizabeth A

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Teleni L, Baker J, Koczwara B, Kimlin MG, Walpole E, Tsai K et al. Clinical outcomes of vitamin D deficiency and supplementation in cancer patients. Nutrition Reviews. 2013 Sep;71(9):611-21. https://doi.org/10.1111/nure.12047