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Abstract
Results of recent studies suggest that circulating levels of vitamin D may play an important role in cancer-specific outcomes. The present systematic review was undertaken to determine the prevalence of vitamin D deficiency (<25 nmol/L) and insufficiency (25-50 nmol/L) in cancer patients and to evaluate the association between circulating calcidiol (the indicator of vitamin D status) and clinical outcomes. A systematic search of original, peer-reviewed studies on calcidiol at cancer diagnosis, and throughout treatment and survival, was conducted yielding 4,706 studies. A total of 37 studies met the inclusion criteria for this review. Reported mean blood calcidiol levels ranged from 24.7 to 87.4 nmol/L, with up to 31% of patients identified as deficient and 67% as insufficient. The efficacy of cholecalciferol supplementation for raising the concentration of circulating calcidiol is unclear; standard supplement regimens of <1,000 IU D₃ /day may not be sufficient to maintain adequate concentrations or prevent decreasing calcidiol. Dose-response studies linking vitamin D status to musculoskeletal and survival outcomes in cancer patients are lacking.
Original language | English |
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Pages (from-to) | 611-21 |
Number of pages | 11 |
Journal | Nutrition Reviews |
Volume | 71 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sept 2013 |
Externally published | Yes |
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Dive into the research topics of 'Clinical outcomes of vitamin D deficiency and supplementation in cancer patients'. Together they form a unique fingerprint.Related Projects
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Oncology Nutrition Research
Isenring, E., Marshall, S., Van der Meij, B., Rigby, R., Teleni, L., Crichton, M. & Tang, X.
1/01/14 → …
Project: Research