Cimetidine and Tranexamic Acid for Upper-Gastrointestinal-Tract Bleeding

D. Barer, D. A. Henry, M. Atkinson, M. J.S. Langman

Research output: Contribution to journalLetterResearch


To the Editor: The article by Barer et al., “Cimetidine and Tranexamic Acid in the Treatment of Acute Upper-Gastrointestinal-Tract Bleeding,” (June 30 issue)* has one important omission. Whenever groups receiving two different therapies that probably work in different ways are being compared with a control group, the design should be a factorial one rather than the simple three-way comparison employed by the authors. If there had been one group receiving tranexamic acid, one group cimetidine, one group a placebo for both drugs, and one group both therapies, the question of interaction between the two drugs and the possibility that they.

Original languageEnglish
Pages (from-to)1328
Number of pages1
JournalNew England Journal of Medicine
Issue number21
Publication statusPublished - 24 Nov 1983
Externally publishedYes


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