TY - JOUR
T1 - Cimetidine and Tranexamic Acid for Upper-Gastrointestinal-Tract Bleeding
AU - Barer, D.
AU - Henry, D. A.
AU - Atkinson, M.
AU - Langman, M. J.S.
PY - 1983/11/24
Y1 - 1983/11/24
N2 - To the Editor: The article by Barer et al., “Cimetidine and Tranexamic Acid in the Treatment of Acute Upper-Gastrointestinal-Tract Bleeding,” (June 30 issue)* has one important omission. Whenever groups receiving two different therapies that probably work in different ways are being compared with a control group, the design should be a factorial one rather than the simple three-way comparison employed by the authors. If there had been one group receiving tranexamic acid, one group cimetidine, one group a placebo for both drugs, and one group both therapies, the question of interaction between the two drugs and the possibility that they.
AB - To the Editor: The article by Barer et al., “Cimetidine and Tranexamic Acid in the Treatment of Acute Upper-Gastrointestinal-Tract Bleeding,” (June 30 issue)* has one important omission. Whenever groups receiving two different therapies that probably work in different ways are being compared with a control group, the design should be a factorial one rather than the simple three-way comparison employed by the authors. If there had been one group receiving tranexamic acid, one group cimetidine, one group a placebo for both drugs, and one group both therapies, the question of interaction between the two drugs and the possibility that they.
UR - http://www.scopus.com/inward/record.url?scp=0021111399&partnerID=8YFLogxK
U2 - 10.1056/NEJM198311243092116
DO - 10.1056/NEJM198311243092116
M3 - Letter
C2 - 6605478
AN - SCOPUS:0021111399
SN - 0028-4793
VL - 309
SP - 1328
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 21
ER -