Cimetidine and ranitidine: Comparison of effects on hepatic drug metabolism

D. A. Henry, G. Kitchingman, G. D. Bell, M. J.S. Langman, I. A. Macdonald

Research output: Contribution to journalArticleResearchpeer-review

127 Citations (Scopus)

Abstract

Paired studies of hepatic microsomal function were conducted in eight subjects during treatment with two histamine H2antagonists, cimetidine and ranitidine. Cimetidine but not ranitidine inhibited the metabolism of antipyrine (phenazone) and demethylation of aminopyrine (aminophenazone) as measured by breath C02production after intravenous injection of C-amino-pyrine. These results suggest that the metabolic inhibitory actions on the liver may be separated from H2 antagonist effects, and that ranitidine has an advantage over cimetidine by not inhibiting microsomal drug oxidative function.

Original languageEnglish
Pages (from-to)775-777
Number of pages3
JournalBritish Medical Journal
Volume281
Issue number6243
DOIs
Publication statusPublished - Nov 1980
Externally publishedYes

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