Abstract
The structural and functional differences between the two main regions of the bladder, the dome and trigone, are well documented. The trigone musculature has been shown to exhibit greater spontaneous activity than the dome (1) and it has been suggested that this may aid contraction of the bladder neck during the storage phase. The mechanisms involved in generation and
modulation of these phasic contractions (PCs) are however still not clear. It has been suggested that they may originate in the mucosal layer and may be modulated by release of transmitters such as acetylcholine from the urothelium.
Recent studies have shown structural
heterogeneity of the urothelium and suburothelium between the trigone, dome and lateral body (2) and functionally we have shown differences in the influence of the mucosa on basal SCs developed in isolate strips from these regions of the pig bladder (3)
modulation of these phasic contractions (PCs) are however still not clear. It has been suggested that they may originate in the mucosal layer and may be modulated by release of transmitters such as acetylcholine from the urothelium.
Recent studies have shown structural
heterogeneity of the urothelium and suburothelium between the trigone, dome and lateral body (2) and functionally we have shown differences in the influence of the mucosa on basal SCs developed in isolate strips from these regions of the pig bladder (3)
| Original language | English |
|---|---|
| Number of pages | 1 |
| Publication status | Published - 2011 |
| Event | International Continence Society 2011 - Glasglow , United Kingdom Duration: 29 Aug 2011 → 2 Sept 2011 |
Conference
| Conference | International Continence Society 2011 |
|---|---|
| Country/Territory | United Kingdom |
| City | Glasglow |
| Period | 29/08/11 → 2/09/11 |