Characterization of the effect of LPS on dendritic cell subset discrimination in spleen

Kristin L Griffiths, Jonathan K H Tan, Helen C O'Neill

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)


The Gram-negative bacterial endotoxin lipopolysaccharide (LPS) is a potent inflammatory mediator and a leading cause of bacterial sepsis. While LPS is known to activate antigen-presenting cells, here we find that LPS down-regulates expression of CD11c and CD11b on splenic dendritic cell subsets, thus confounding the ability to identify these subsets following treatment. This has implications with regard to tracking the response to LPS in terms of the cell subsets involved, and should be considered whenever such studies are undertaken.

Original languageEnglish
Pages (from-to)1908-12
Number of pages5
JournalJournal of Cellular and Molecular Medicine
Issue number9
Publication statusPublished - Sep 2014
Externally publishedYes


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