TY - JOUR
T1 - Cellular effects of pyocyanin, a secreted virulence factor of Pseudomonas aeruginosa
AU - Hall, Susan
AU - McDermott, Catherine
AU - Anoopkumar-Dukie, Shailendra
AU - McFarland, Amelia J.
AU - Forbes, Amanda
AU - Perkins, Anthony V.
AU - Davey, Andrew K.
AU - Chess-Williams, Russ
AU - Kiefel, Milton J.
AU - Arora, Devinder
AU - Grant, Gary D.
PY - 2016/8/9
Y1 - 2016/8/9
N2 - Pyocyanin has recently emerged as an important virulence factor produced by Pseudomonas aeruginosa. The redox-active tricyclic zwitterion has been shown to have a number of potential effects on various organ systems in vitro, including the respiratory, cardiovascular, urological, and central nervous systems. It has been shown that a large number of the effects to these systems are via the formation of reactive oxygen species. The limitations of studies are, to date, focused on the localized effect of the release of pyocyanin (PCN). It has been postulated that, given its chemical properties, PCN is able to readily cross biological membranes, however studies have yet to be undertaken to evaluate this effect. This review highlights the possible manifestations of PCN exposure; however, most studies to date are in vitro. Further high quality in vivo studies are needed to fully assess the physiological manifestations of PCN exposure on the various body systems.
AB - Pyocyanin has recently emerged as an important virulence factor produced by Pseudomonas aeruginosa. The redox-active tricyclic zwitterion has been shown to have a number of potential effects on various organ systems in vitro, including the respiratory, cardiovascular, urological, and central nervous systems. It has been shown that a large number of the effects to these systems are via the formation of reactive oxygen species. The limitations of studies are, to date, focused on the localized effect of the release of pyocyanin (PCN). It has been postulated that, given its chemical properties, PCN is able to readily cross biological membranes, however studies have yet to be undertaken to evaluate this effect. This review highlights the possible manifestations of PCN exposure; however, most studies to date are in vitro. Further high quality in vivo studies are needed to fully assess the physiological manifestations of PCN exposure on the various body systems.
UR - http://www.scopus.com/inward/record.url?scp=84982275962&partnerID=8YFLogxK
U2 - 10.3390/toxins8080236
DO - 10.3390/toxins8080236
M3 - Review article
AN - SCOPUS:84982275962
SN - 2072-6651
VL - 8
SP - 1
EP - 14
JO - Toxins
JF - Toxins
IS - 8
M1 - 236
ER -