Cellular effects of pyocyanin, a secreted virulence factor of Pseudomonas aeruginosa

Susan Hall, Catherine McDermott, Shailendra Anoopkumar-Dukie, Amelia J. McFarland, Amanda Forbes, Anthony V. Perkins, Andrew K. Davey, Russ Chess-Williams, Milton J. Kiefel, Devinder Arora, Gary D. Grant*

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

84 Citations (Scopus)
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Abstract

Pyocyanin has recently emerged as an important virulence factor produced by Pseudomonas aeruginosa. The redox-active tricyclic zwitterion has been shown to have a number of potential effects on various organ systems in vitro, including the respiratory, cardiovascular, urological, and central nervous systems. It has been shown that a large number of the effects to these systems are via the formation of reactive oxygen species. The limitations of studies are, to date, focused on the localized effect of the release of pyocyanin (PCN). It has been postulated that, given its chemical properties, PCN is able to readily cross biological membranes, however studies have yet to be undertaken to evaluate this effect. This review highlights the possible manifestations of PCN exposure; however, most studies to date are in vitro. Further high quality in vivo studies are needed to fully assess the physiological manifestations of PCN exposure on the various body systems.

Original languageEnglish
Article number236
Pages (from-to)1-14
Number of pages14
JournalToxins
Volume8
Issue number8
DOIs
Publication statusPublished - 9 Aug 2016

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    Hall, S., McDermott, C., Anoopkumar-Dukie, S., McFarland, A. J., Forbes, A., Perkins, A. V., Davey, A. K., Chess-Williams, R., Kiefel, M. J., Arora, D., & Grant, G. D. (2016). Cellular effects of pyocyanin, a secreted virulence factor of Pseudomonas aeruginosa. Toxins, 8(8), 1-14. [236]. https://doi.org/10.3390/toxins8080236