Cardiovascular dynamics during exercise are related to blood rheology

Michael J. Simmonds, Julien Tripette, Surendran Sabapathy, Sonya M. Marshall-Gradisnik, Philippe Connes

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

Background: The principal determinants of oxygen uptake (V̇O 2) kinetics are controversial, with dynamic changes in central and peripheral factors mediating oxygen supply and utilisation suggested to be limiting. The aim of this study was to determine whether important parameters of blood rheology were related to the exercise-induced time-course changes in V̇O 2 and cardiac output (Q̇c), or steady-state arteriovenous oxygen difference (a-vO 2D) during submaximal cycling. Methods and Results: Blood was collected from ten healthy, recreationally active males and females (age: 21.7 ± 1.3 yr; body mass index: 22.7 ± 2.0 kg·m -2), before each subject cycled at 105% of the first ventilatory threshold. Red blood cell aggregation was negatively correlated with steady-state V̇O 2 during exercise and the a-vO 2D at rest (r = -0.73, p < 0.05), and positively correlated to Q̇c at rest (r = 0.71, p < 0.05). Blood viscosity at various shear rates was negatively correlated with the time constant of V̇O 2 (all p < 0.01) on-transient kinetics. Red blood cell deformability at various shear stress was positively correlated to the time constant of V̇O 2 (all p < 0.05) on-transient kinetics. Conclusions: The findings of the present study suggest that the rheological properties of blood may modulate, at least in part, the rate of change in the uptake and/or utilisation of oxygen at the onset of exercise.

Original languageEnglish
Pages (from-to)231-241
Number of pages11
JournalClinical Hemorheology and Microcirculation
Volume49
Issue number1-4
DOIs
Publication statusPublished - 2011

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Rheology
Oxygen
Erythrocytes
Cell Aggregation
Blood Viscosity
Cardiac Output
Body Mass Index

Cite this

Simmonds, M. J., Tripette, J., Sabapathy, S., Marshall-Gradisnik, S. M., & Connes, P. (2011). Cardiovascular dynamics during exercise are related to blood rheology. Clinical Hemorheology and Microcirculation, 49(1-4), 231-241. https://doi.org/10.3233/CH-2011-1473
Simmonds, Michael J. ; Tripette, Julien ; Sabapathy, Surendran ; Marshall-Gradisnik, Sonya M. ; Connes, Philippe. / Cardiovascular dynamics during exercise are related to blood rheology. In: Clinical Hemorheology and Microcirculation. 2011 ; Vol. 49, No. 1-4. pp. 231-241.
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abstract = "Background: The principal determinants of oxygen uptake (V̇O 2) kinetics are controversial, with dynamic changes in central and peripheral factors mediating oxygen supply and utilisation suggested to be limiting. The aim of this study was to determine whether important parameters of blood rheology were related to the exercise-induced time-course changes in V̇O 2 and cardiac output (Q̇c), or steady-state arteriovenous oxygen difference (a-vO 2D) during submaximal cycling. Methods and Results: Blood was collected from ten healthy, recreationally active males and females (age: 21.7 ± 1.3 yr; body mass index: 22.7 ± 2.0 kg·m -2), before each subject cycled at 105{\%} of the first ventilatory threshold. Red blood cell aggregation was negatively correlated with steady-state V̇O 2 during exercise and the a-vO 2D at rest (r = -0.73, p < 0.05), and positively correlated to Q̇c at rest (r = 0.71, p < 0.05). Blood viscosity at various shear rates was negatively correlated with the time constant of V̇O 2 (all p < 0.01) on-transient kinetics. Red blood cell deformability at various shear stress was positively correlated to the time constant of V̇O 2 (all p < 0.05) on-transient kinetics. Conclusions: The findings of the present study suggest that the rheological properties of blood may modulate, at least in part, the rate of change in the uptake and/or utilisation of oxygen at the onset of exercise.",
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Simmonds, MJ, Tripette, J, Sabapathy, S, Marshall-Gradisnik, SM & Connes, P 2011, 'Cardiovascular dynamics during exercise are related to blood rheology' Clinical Hemorheology and Microcirculation, vol. 49, no. 1-4, pp. 231-241. https://doi.org/10.3233/CH-2011-1473

Cardiovascular dynamics during exercise are related to blood rheology. / Simmonds, Michael J.; Tripette, Julien; Sabapathy, Surendran; Marshall-Gradisnik, Sonya M.; Connes, Philippe.

In: Clinical Hemorheology and Microcirculation, Vol. 49, No. 1-4, 2011, p. 231-241.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Cardiovascular dynamics during exercise are related to blood rheology

AU - Simmonds, Michael J.

AU - Tripette, Julien

AU - Sabapathy, Surendran

AU - Marshall-Gradisnik, Sonya M.

AU - Connes, Philippe

PY - 2011

Y1 - 2011

N2 - Background: The principal determinants of oxygen uptake (V̇O 2) kinetics are controversial, with dynamic changes in central and peripheral factors mediating oxygen supply and utilisation suggested to be limiting. The aim of this study was to determine whether important parameters of blood rheology were related to the exercise-induced time-course changes in V̇O 2 and cardiac output (Q̇c), or steady-state arteriovenous oxygen difference (a-vO 2D) during submaximal cycling. Methods and Results: Blood was collected from ten healthy, recreationally active males and females (age: 21.7 ± 1.3 yr; body mass index: 22.7 ± 2.0 kg·m -2), before each subject cycled at 105% of the first ventilatory threshold. Red blood cell aggregation was negatively correlated with steady-state V̇O 2 during exercise and the a-vO 2D at rest (r = -0.73, p < 0.05), and positively correlated to Q̇c at rest (r = 0.71, p < 0.05). Blood viscosity at various shear rates was negatively correlated with the time constant of V̇O 2 (all p < 0.01) on-transient kinetics. Red blood cell deformability at various shear stress was positively correlated to the time constant of V̇O 2 (all p < 0.05) on-transient kinetics. Conclusions: The findings of the present study suggest that the rheological properties of blood may modulate, at least in part, the rate of change in the uptake and/or utilisation of oxygen at the onset of exercise.

AB - Background: The principal determinants of oxygen uptake (V̇O 2) kinetics are controversial, with dynamic changes in central and peripheral factors mediating oxygen supply and utilisation suggested to be limiting. The aim of this study was to determine whether important parameters of blood rheology were related to the exercise-induced time-course changes in V̇O 2 and cardiac output (Q̇c), or steady-state arteriovenous oxygen difference (a-vO 2D) during submaximal cycling. Methods and Results: Blood was collected from ten healthy, recreationally active males and females (age: 21.7 ± 1.3 yr; body mass index: 22.7 ± 2.0 kg·m -2), before each subject cycled at 105% of the first ventilatory threshold. Red blood cell aggregation was negatively correlated with steady-state V̇O 2 during exercise and the a-vO 2D at rest (r = -0.73, p < 0.05), and positively correlated to Q̇c at rest (r = 0.71, p < 0.05). Blood viscosity at various shear rates was negatively correlated with the time constant of V̇O 2 (all p < 0.01) on-transient kinetics. Red blood cell deformability at various shear stress was positively correlated to the time constant of V̇O 2 (all p < 0.05) on-transient kinetics. Conclusions: The findings of the present study suggest that the rheological properties of blood may modulate, at least in part, the rate of change in the uptake and/or utilisation of oxygen at the onset of exercise.

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DO - 10.3233/CH-2011-1473

M3 - Article

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SP - 231

EP - 241

JO - Clinical Hemorheology

JF - Clinical Hemorheology

SN - 1386-0291

IS - 1-4

ER -