Carcinogenic potential of sanguinarine, a phytochemical used in ‘therapeutic’ black salve and mouthwash

Andrew Croaker, Graham J. King, John H. Pyne, Shailendra Anoopkumar-Dukie, Vilim Simanek, Lei Liu

Research output: Contribution to journalReview articleResearchpeer-review

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Abstract

Black salves are escharotic skin cancer therapies in clinical use since the mid 19th century. Sanguinaria canadensis, a major ingredient of black salve formulations, contains a number of bioactive phytochemicals including the alkaloid sanguinarine. Despite its prolonged history of clinical use, conflicting experimental results have prevented the carcinogenic potential of sanguinarine from being definitively determined. Sanguinarine has a molecular structure similar to known polyaromatic hydrocarbon carcinogens and is a DNA intercalator. Sanguinarine also generates oxidative and endoplasmic reticulum stress resulting in the unfolded protein response and the formation of 8-hydroxyguanine genetic lesions. Sanguinarine has been the subject of contradictory in vitro and in vivo genotoxicity and murine carcinogenesis test results that have delayed its carcinogenic classification. Despite this, epidemiological studies have linked mouthwash that contains sanguinarine with the development of oral leukoplakia. Sanguinarine is also proposed as an aetiological agent in gallbladder carcinoma. This literature review investigates the carcinogenic potential of sanguinarine. Reasons for contradictory genotoxicity and carcinogenesis results are explored, knowledge gaps identified and a strategy for determining the carcinogenic potential of sanguinarine especialy relating to black salve are discussed. As patients continue to apply black salve, especially to skin regions suffering from field cancerization and skin malignancies, an understanding of the genotoxic and carcinogenic potential of sanguinarine is of urgent clinical relevance.

Original languageEnglish
Pages (from-to)46-56
Number of pages11
JournalMutation Research - Reviews in Mutation Research
Volume774
DOIs
Publication statusPublished - 1 Oct 2017
Externally publishedYes

Fingerprint

Mouthwashes
Phytochemicals
Ointments
Therapeutics
Sanguinaria
Carcinogenicity Tests
sanguinarine
Oral Leukoplakia
Intercalating Agents
Unfolded Protein Response
Skin
Endoplasmic Reticulum Stress
Skin Neoplasms
Hydrocarbons
Gallbladder
Molecular Structure
Alkaloids
Carcinogens
Epidemiologic Studies
Carcinogenesis

Cite this

Croaker, Andrew ; King, Graham J. ; Pyne, John H. ; Anoopkumar-Dukie, Shailendra ; Simanek, Vilim ; Liu, Lei. / Carcinogenic potential of sanguinarine, a phytochemical used in ‘therapeutic’ black salve and mouthwash. In: Mutation Research - Reviews in Mutation Research. 2017 ; Vol. 774. pp. 46-56.
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Carcinogenic potential of sanguinarine, a phytochemical used in ‘therapeutic’ black salve and mouthwash. / Croaker, Andrew; King, Graham J.; Pyne, John H.; Anoopkumar-Dukie, Shailendra; Simanek, Vilim; Liu, Lei.

In: Mutation Research - Reviews in Mutation Research, Vol. 774, 01.10.2017, p. 46-56.

Research output: Contribution to journalReview articleResearchpeer-review

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