Botulinum neurotoxin A (BoNT/A) attenuates bladder afferent nerve firing and prevents ATP release from the urothelium

Donna M. Daly; Valerie M. Collins; Neil G. McKay; Donna J Sellers; Christopher Chapple; David Grundy

doi:10.1016/S1569-9056(12)60371-6

Botulinum neurotoxin A (BoNT/A) attenuates bladder afferent nerve firing and prevents ATP release from the urothelium

Donna M. Daly
, Valerie M. Collins
, Neil G. McKay
, Donna J Sellers
, Christopher Chapple
, David Grundy

Centre for Urology Research

Research output: Contribution to journal › Meeting Abstract › Research › peer-review

Abstract

INTRODUCTION & OBJECTIVES: Urinary urgency and frequency are the cardinal symptoms of overactive bladder syndrome suggesting that changes in sensory function may be the underlying cause. Trans-urothelial injection of BoNT/A has recently proved to be an effective treatment of urgency; however its mechanism of action remains unclear. The aim of this study was to examine the effect of BoNT/A on the afferent response to bladder filling and the release of ATP from the urothelium.

Original language	English
Pages (from-to)	e374-e374
Number of pages	1
Journal	European Urology, Supplements
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/S1569-9056(12)60371-6
Publication status	Published - Feb 2012

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title = "Botulinum neurotoxin A (BoNT/A) attenuates bladder afferent nerve firing and prevents ATP release from the urothelium",

abstract = "INTRODUCTION \& OBJECTIVES: Urinary urgency and frequency are the cardinal symptoms of overactive bladder syndrome suggesting that changes in sensory function may be the underlying cause. Trans-urothelial injection of BoNT/A has recently proved to be an effective treatment of urgency; however its mechanism of action remains unclear. The aim of this study was to examine the effect of BoNT/A on the afferent response to bladder filling and the release of ATP from the urothelium.",

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AU - Daly, Donna M.

AU - Collins, Valerie M.

AU - McKay, Neil G.

AU - Sellers, Donna J

AU - Chapple, Christopher

AU - Grundy, David

PY - 2012/2

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N2 - INTRODUCTION & OBJECTIVES: Urinary urgency and frequency are the cardinal symptoms of overactive bladder syndrome suggesting that changes in sensory function may be the underlying cause. Trans-urothelial injection of BoNT/A has recently proved to be an effective treatment of urgency; however its mechanism of action remains unclear. The aim of this study was to examine the effect of BoNT/A on the afferent response to bladder filling and the release of ATP from the urothelium.

AB - INTRODUCTION & OBJECTIVES: Urinary urgency and frequency are the cardinal symptoms of overactive bladder syndrome suggesting that changes in sensory function may be the underlying cause. Trans-urothelial injection of BoNT/A has recently proved to be an effective treatment of urgency; however its mechanism of action remains unclear. The aim of this study was to examine the effect of BoNT/A on the afferent response to bladder filling and the release of ATP from the urothelium.

U2 - 10.1016/S1569-9056(12)60371-6

DO - 10.1016/S1569-9056(12)60371-6

M3 - Meeting Abstract

SN - 1569-9056

VL - 11

SP - e374-e374

JO - European Urology, Supplements

JF - European Urology, Supplements

IS - 1

ER -

Botulinum neurotoxin A (BoNT/A) attenuates bladder afferent nerve firing and prevents ATP release from the urothelium

Abstract

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