Botulinum neurotoxin A (BoNT/A) attenuates bladder afferent nerve firing and prevents ATP release from the urothelium

Donna M. Daly, Valerie M. Collins, Neil G. McKay, Donna J Sellers, Christopher Chapple, David Grundy

Research output: Contribution to journalMeeting AbstractResearchpeer-review


INTRODUCTION & OBJECTIVES: Urinary urgency and frequency are the cardinal symptoms of overactive bladder syndrome suggesting that changes in sensory function may be the underlying cause. Trans-urothelial injection of BoNT/A has recently proved to be an effective treatment of urgency; however its mechanism of action remains unclear. The aim of this study was to examine the effect of BoNT/A on the afferent response to bladder filling and the release of ATP from the urothelium.
Original languageEnglish
Pages (from-to)e374-e374
Number of pages1
JournalEuropean Urology, Supplements
Issue number1
Publication statusPublished - Feb 2012

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