INTRODUCTION & OBJECTIVES: Urinary urgency and frequency are the cardinal symptoms of overactive bladder syndrome suggesting that changes in sensory function may be the underlying cause. Trans-urothelial injection of BoNT/A has recently proved to be an effective treatment of urgency; however its mechanism of action remains unclear. The aim of this study was to examine the effect of BoNT/A on the afferent response to bladder filling and the release of ATP from the urothelium.
Daly, D. M., Collins, V. M., McKay, N. G., Sellers, D. J., Chapple, C., & Grundy, D. (2012). Botulinum neurotoxin A (BoNT/A) attenuates bladder afferent nerve firing and prevents ATP release from the urothelium. European Urology, Supplements, 11(1), e374-e374. https://doi.org/10.1016/S1569-9056(12)60371-6