Botulinum neurotoxin A (BoNT/A) attenuates bladder afferent nerve firing and prevents ATP release from the urothelium

Donna M. Daly, Valerie M. Collins, Neil G. McKay, Donna J Sellers, Christopher Chapple, David Grundy

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Abstract

INTRODUCTION & OBJECTIVES: Urinary urgency and frequency are the cardinal symptoms of overactive bladder syndrome suggesting that changes in sensory function may be the underlying cause. Trans-urothelial injection of BoNT/A has recently proved to be an effective treatment of urgency; however its mechanism of action remains unclear. The aim of this study was to examine the effect of BoNT/A on the afferent response to bladder filling and the release of ATP from the urothelium.
Original languageEnglish
Pages (from-to)e374-e374
Number of pages1
JournalEuropean Urology, Supplements
Volume11
Issue number1
DOIs
Publication statusPublished - Feb 2012

Cite this

Daly, Donna M. ; Collins, Valerie M. ; McKay, Neil G. ; Sellers, Donna J ; Chapple, Christopher ; Grundy, David. / Botulinum neurotoxin A (BoNT/A) attenuates bladder afferent nerve firing and prevents ATP release from the urothelium. In: European Urology, Supplements. 2012 ; Vol. 11, No. 1. pp. e374-e374.
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Botulinum neurotoxin A (BoNT/A) attenuates bladder afferent nerve firing and prevents ATP release from the urothelium. / Daly, Donna M.; Collins, Valerie M.; McKay, Neil G.; Sellers, Donna J; Chapple, Christopher; Grundy, David.

In: European Urology, Supplements, Vol. 11, No. 1, 02.2012, p. e374-e374.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

TY - JOUR

T1 - Botulinum neurotoxin A (BoNT/A) attenuates bladder afferent nerve firing and prevents ATP release from the urothelium

AU - Daly, Donna M.

AU - Collins, Valerie M.

AU - McKay, Neil G.

AU - Sellers, Donna J

AU - Chapple, Christopher

AU - Grundy, David

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AB - INTRODUCTION & OBJECTIVES: Urinary urgency and frequency are the cardinal symptoms of overactive bladder syndrome suggesting that changes in sensory function may be the underlying cause. Trans-urothelial injection of BoNT/A has recently proved to be an effective treatment of urgency; however its mechanism of action remains unclear. The aim of this study was to examine the effect of BoNT/A on the afferent response to bladder filling and the release of ATP from the urothelium.

U2 - 10.1016/S1569-9056(12)60371-6

DO - 10.1016/S1569-9056(12)60371-6

M3 - Meeting Abstract

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SP - e374-e374

JO - European Urology, Supplements

JF - European Urology, Supplements

SN - 1569-9056

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