Blood viscosity and hemodynamics during exercise

Philippe Connes, Aurélien Pichon, Marie Dominique Hardy-Dessources, Xavier Waltz, Yann Lamarre, Michael J. Simmonds, Julien Tripette

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Abstract

We tested the effects of submaximal exercise on blood viscosity (η b), nitric oxide production (NO) and hemodynamics. Relationships between the exercise-induced changes that occurred in these parameters were investigated. Nine subjects performed exercise for 15 min at 105% of the first ventilatory threshold. Mean arterial pressure (MAP) and cardiac output (Qc) were measured, allowing the determination of systemic vascular resistance (SVR). Blood was sampled at rest and at the end of exercise. The η b was determined at high shear rate and was used to calculate systemic vascular hindrance (VH). NO production was estimated by measuring plasma concentrations of NO stable end products (NOx). Qc, MAP, η b and NOx, increased with exercise, whereas SVR and VH decreased. The changes between rest and exercise were calculated and tested for correlations. We observed: 1) a positive correlation between the increase in η b and the increase in NOx; 2) a negative correlation between the increase in NOx and the decrease in VH; 3) a negative correlation between the increase in η b and the decrease in SVR. Although the increase in Qc and blood flow during exercise probably promoted NO production due to shear dependent stimulation of the endothelium, the present results also support that the rise in η b during exercise may be necessary for NO production and adequate vasodilation.

Original languageEnglish
Pages (from-to)101-109
Number of pages9
JournalClinical Hemorheology and Microcirculation
Volume51
Issue number2
DOIs
Publication statusPublished - 2012

Fingerprint

Blood Viscosity
Nitric Oxide
Hemodynamics
Vascular Resistance
Blood Vessels
Arterial Pressure
Vasodilation
Cardiac Output
Endothelium

Cite this

Connes, P., Pichon, A., Hardy-Dessources, M. D., Waltz, X., Lamarre, Y., Simmonds, M. J., & Tripette, J. (2012). Blood viscosity and hemodynamics during exercise. Clinical Hemorheology and Microcirculation, 51(2), 101-109. https://doi.org/10.3233/CH-2011-1515
Connes, Philippe ; Pichon, Aurélien ; Hardy-Dessources, Marie Dominique ; Waltz, Xavier ; Lamarre, Yann ; Simmonds, Michael J. ; Tripette, Julien. / Blood viscosity and hemodynamics during exercise. In: Clinical Hemorheology and Microcirculation. 2012 ; Vol. 51, No. 2. pp. 101-109.
@article{f4bebd01e68447cbb58dad4183614cba,
title = "Blood viscosity and hemodynamics during exercise",
abstract = "We tested the effects of submaximal exercise on blood viscosity (η b), nitric oxide production (NO) and hemodynamics. Relationships between the exercise-induced changes that occurred in these parameters were investigated. Nine subjects performed exercise for 15 min at 105{\%} of the first ventilatory threshold. Mean arterial pressure (MAP) and cardiac output (Qc) were measured, allowing the determination of systemic vascular resistance (SVR). Blood was sampled at rest and at the end of exercise. The η b was determined at high shear rate and was used to calculate systemic vascular hindrance (VH). NO production was estimated by measuring plasma concentrations of NO stable end products (NOx). Qc, MAP, η b and NOx, increased with exercise, whereas SVR and VH decreased. The changes between rest and exercise were calculated and tested for correlations. We observed: 1) a positive correlation between the increase in η b and the increase in NOx; 2) a negative correlation between the increase in NOx and the decrease in VH; 3) a negative correlation between the increase in η b and the decrease in SVR. Although the increase in Qc and blood flow during exercise probably promoted NO production due to shear dependent stimulation of the endothelium, the present results also support that the rise in η b during exercise may be necessary for NO production and adequate vasodilation.",
author = "Philippe Connes and Aur{\'e}lien Pichon and Hardy-Dessources, {Marie Dominique} and Xavier Waltz and Yann Lamarre and Simmonds, {Michael J.} and Julien Tripette",
year = "2012",
doi = "10.3233/CH-2011-1515",
language = "English",
volume = "51",
pages = "101--109",
journal = "Clinical Hemorheology",
issn = "1386-0291",
publisher = "IOS Press",
number = "2",

}

Connes, P, Pichon, A, Hardy-Dessources, MD, Waltz, X, Lamarre, Y, Simmonds, MJ & Tripette, J 2012, 'Blood viscosity and hemodynamics during exercise' Clinical Hemorheology and Microcirculation, vol. 51, no. 2, pp. 101-109. https://doi.org/10.3233/CH-2011-1515

Blood viscosity and hemodynamics during exercise. / Connes, Philippe; Pichon, Aurélien; Hardy-Dessources, Marie Dominique; Waltz, Xavier; Lamarre, Yann; Simmonds, Michael J.; Tripette, Julien.

In: Clinical Hemorheology and Microcirculation, Vol. 51, No. 2, 2012, p. 101-109.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Blood viscosity and hemodynamics during exercise

AU - Connes, Philippe

AU - Pichon, Aurélien

AU - Hardy-Dessources, Marie Dominique

AU - Waltz, Xavier

AU - Lamarre, Yann

AU - Simmonds, Michael J.

AU - Tripette, Julien

PY - 2012

Y1 - 2012

N2 - We tested the effects of submaximal exercise on blood viscosity (η b), nitric oxide production (NO) and hemodynamics. Relationships between the exercise-induced changes that occurred in these parameters were investigated. Nine subjects performed exercise for 15 min at 105% of the first ventilatory threshold. Mean arterial pressure (MAP) and cardiac output (Qc) were measured, allowing the determination of systemic vascular resistance (SVR). Blood was sampled at rest and at the end of exercise. The η b was determined at high shear rate and was used to calculate systemic vascular hindrance (VH). NO production was estimated by measuring plasma concentrations of NO stable end products (NOx). Qc, MAP, η b and NOx, increased with exercise, whereas SVR and VH decreased. The changes between rest and exercise were calculated and tested for correlations. We observed: 1) a positive correlation between the increase in η b and the increase in NOx; 2) a negative correlation between the increase in NOx and the decrease in VH; 3) a negative correlation between the increase in η b and the decrease in SVR. Although the increase in Qc and blood flow during exercise probably promoted NO production due to shear dependent stimulation of the endothelium, the present results also support that the rise in η b during exercise may be necessary for NO production and adequate vasodilation.

AB - We tested the effects of submaximal exercise on blood viscosity (η b), nitric oxide production (NO) and hemodynamics. Relationships between the exercise-induced changes that occurred in these parameters were investigated. Nine subjects performed exercise for 15 min at 105% of the first ventilatory threshold. Mean arterial pressure (MAP) and cardiac output (Qc) were measured, allowing the determination of systemic vascular resistance (SVR). Blood was sampled at rest and at the end of exercise. The η b was determined at high shear rate and was used to calculate systemic vascular hindrance (VH). NO production was estimated by measuring plasma concentrations of NO stable end products (NOx). Qc, MAP, η b and NOx, increased with exercise, whereas SVR and VH decreased. The changes between rest and exercise were calculated and tested for correlations. We observed: 1) a positive correlation between the increase in η b and the increase in NOx; 2) a negative correlation between the increase in NOx and the decrease in VH; 3) a negative correlation between the increase in η b and the decrease in SVR. Although the increase in Qc and blood flow during exercise probably promoted NO production due to shear dependent stimulation of the endothelium, the present results also support that the rise in η b during exercise may be necessary for NO production and adequate vasodilation.

UR - http://www.scopus.com/inward/record.url?scp=84861976316&partnerID=8YFLogxK

U2 - 10.3233/CH-2011-1515

DO - 10.3233/CH-2011-1515

M3 - Article

VL - 51

SP - 101

EP - 109

JO - Clinical Hemorheology

JF - Clinical Hemorheology

SN - 1386-0291

IS - 2

ER -

Connes P, Pichon A, Hardy-Dessources MD, Waltz X, Lamarre Y, Simmonds MJ et al. Blood viscosity and hemodynamics during exercise. Clinical Hemorheology and Microcirculation. 2012;51(2):101-109. https://doi.org/10.3233/CH-2011-1515