Blood Pressure and Heart Rate Responses following Dietary Protein Intake in Older Men

Avneet Oberoi, Caroline Giezenaar, Kylie Lange, Karen L. Jones, Michael Horowitz, Ian Chapman, Stijn Soenen*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Postprandial hypotension (PPH) occurs frequently in older people >65 years old. Proteinrich supplements, particularly whey protein (WP), are increasingly used by older people for various health benefits. We have reported that 70 g WP drinks cause significant, and in some cases marked, falls in blood pressure (BP) in older men. The effects of lower, more widely used, doses (similar to 30 g) on systolic (SBP) and diastolic (DBP) blood pressure and heart rate (HR) are not known. In a randomized order, eight older men (age: 72 +/- 1 years; body mass index (BMI): 25 +/- 1 kg/m(2)) after overnight fast ingested a drink containing (i) a non-caloric control (similar to 2 kcal), (ii) 30 g of whey protein (120 kcal; 'WP30'), or (iii) 70 g of whey protein (280 kcal; 'WP70'). The BP and HR were measured in this pilot study with an automated device before and at 3-min intervals for 180 min following drink ingestion. Drink condition effects were determined by repeated-measures ANOVA. The SBP decreased after both WP drinks compared to the control (p = 0.016), particularly between 120 and 180 min, with no difference in the effects of WP30 and WP70. The SBP decreased by >= 20 mmHg in more than 50% of people after both WP drinks (WP30: 63%; WP70: 75%) compared to 38% after the control. The maximum fall in the SBP occurred during the third hour, with the nadir occurring latest after WP70. The DBP decreased non-significantly by several mmHg more after the WP drinks than after the control. The maximum HR increases occurred during the third hour, with the greatest increase after WP70. The SBP decreased after both WP drinks compared to the control, with the effects most evident between 120 and 180 min. Accordingly, ingestion of even relatively modest protein loads in older men has the potential to cause PPH.

Original languageEnglish
Article number1913
Number of pages8
JournalNutrients
Volume14
Issue number9
DOIs
Publication statusPublished - 3 May 2022

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