Blood lipids and prostate cancer: a Mendelian randomization analysis

Caroline J. Bull; Carolina Bonilla; Jeff M.P. Holly; Claire M. Perks; Neil Davies; Philip Haycock; Oriana Hoi Yun Yu; J. Brent Richards; Rosalind Eeles; Doug Easton; The PRACTICAL consortium; Jyotsna Batra; Richard M. Martin

doi:10.1002/cam4.695

Blood lipids and prostate cancer: a Mendelian randomization analysis

Caroline J. Bull, Carolina Bonilla, Jeff M.P. Holly, Claire M. Perks, Neil Davies, Philip Haycock, Oriana Hoi Yun Yu, J. Brent Richards, Rosalind Eeles, Doug Easton, The PRACTICAL consortium, Jyotsna Batra, Richard M. Martin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Genetic risk scores were used as unconfounded instruments for specific lipid traits (Mendelian randomization) to assess whether circulating lipids causally influence prostate cancer risk. Data from 22,249 prostate cancer cases and 22,133 controls from 22 studies within the international PRACTICAL consortium were analyzed. Allele scores based on single nucleotide polymorphisms (SNPs) previously reported to be uniquely associated with each of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride (TG) levels, were first validated in an independent dataset, and then entered into logistic regression models to estimate the presence (and direction) of any causal effect of each lipid trait on prostate cancer risk. There was weak evidence for an association between the LDL genetic score and cancer grade: the odds ratio (OR) per genetically instrumented standard deviation (SD) in LDL, comparing high- (≥7 Gleason score) versus low-grade (

Original language	English
Pages (from-to)	1125-1136
Number of pages	12
Journal	Cancer Medicine
Volume	5
Issue number	6
Early online date	19 Mar 2016
DOIs	https://doi.org/10.1002/cam4.695
Publication status	Published - 28 Jun 2016
Externally published	Yes

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Blood lipids and prostate cancer a Mendelian randomization analysisFinal published version, 350 KBLicence: CC BY

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title = "Blood lipids and prostate cancer: a Mendelian randomization analysis",

abstract = "Genetic risk scores were used as unconfounded instruments for specific lipid traits (Mendelian randomization) to assess whether circulating lipids causally influence prostate cancer risk. Data from 22,249 prostate cancer cases and 22,133 controls from 22 studies within the international PRACTICAL consortium were analyzed. Allele scores based on single nucleotide polymorphisms (SNPs) previously reported to be uniquely associated with each of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride (TG) levels, were first validated in an independent dataset, and then entered into logistic regression models to estimate the presence (and direction) of any causal effect of each lipid trait on prostate cancer risk. There was weak evidence for an association between the LDL genetic score and cancer grade: the odds ratio (OR) per genetically instrumented standard deviation (SD) in LDL, comparing high- (≥7 Gleason score) versus low-grade (",

author = "Bull, {Caroline J.} and Carolina Bonilla and Holly, {Jeff M.P.} and Perks, {Claire M.} and Neil Davies and Philip Haycock and Yu, {Oriana Hoi Yun} and Richards, {J. Brent} and Rosalind Eeles and Doug Easton and {The PRACTICAL consortium} and Zsofia Kote-Jarai and {Amin Al Olama}, Ali and Sara Benlloch and Kenneth Muir and Giles, {Graham G.} and MacInnis, {Robert J.} and Fredrik Wiklund and Henrik Gronberg and Haiman, {Christopher A.} and Johanna Schleutker and Nordestgaard, {B{\o}rge G.} and Travis, {Ruth C.} and David Neal and Nora Pashayan and Khaw, {Kay Tee} and Stanford, {Janet L.} and Blot, {William J.} and Stephen Thibodeau and Christiane Maier and Kibel, {Adam S.} and Cezary Cybulski and Lisa Cannon-Albright and Hermann Brenner and Jong Park and Radka Kaneva and Jyotsna Batra and Teixeira, {Manuel R.} and Agnieszka Micheal and Hardev Pandha and Smith, {George Davey} and Lewis, {Sarah J.} and Martin, {Richard M.}",

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AU - Holly, Jeff M.P.

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AU - Haycock, Philip

AU - Yu, Oriana Hoi Yun

AU - Richards, J. Brent

AU - Eeles, Rosalind

AU - Easton, Doug

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AU - Kote-Jarai, Zsofia

AU - Amin Al Olama, Ali

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AU - Gronberg, Henrik

AU - Haiman, Christopher A.

AU - Schleutker, Johanna

AU - Nordestgaard, Børge G.

AU - Travis, Ruth C.

AU - Neal, David

AU - Pashayan, Nora

AU - Khaw, Kay Tee

AU - Stanford, Janet L.

AU - Blot, William J.

AU - Thibodeau, Stephen

AU - Maier, Christiane

AU - Kibel, Adam S.

AU - Cybulski, Cezary

AU - Cannon-Albright, Lisa

AU - Brenner, Hermann

AU - Park, Jong

AU - Kaneva, Radka

AU - Batra, Jyotsna

AU - Teixeira, Manuel R.

AU - Micheal, Agnieszka

AU - Pandha, Hardev

AU - Smith, George Davey

AU - Lewis, Sarah J.

AU - Martin, Richard M.

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JO - Cancer Medicine

JF - Cancer Medicine

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ER -

Blood lipids and prostate cancer: a Mendelian randomization analysis

Abstract

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