Blood kinetics of four intraperitoneally administered therapeutic candidate bacteriophages in healthy and neutropenic mice

Jumpei Uchiyama, Yoshihiro Maeda, Iyo Takemura, Russ Chess-Williams, Hiroshi Wakiguchi, Shigenobu Matsuzaki

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Abstract

Due to multiple-drug resistant bacteria, phage therapy is being revisited. Although most animal experiments focus on therapeutic efficacy, the blood clearance kinetics of phages have not been well described. For further development of an efficient therapeutic strategy, information on phage blood kinetics is important. In this study, time-course concentration changes in peripheral blood of healthy and neutropenic mice were measured using four therapeutic phages (φMR11, KPP10, φEF24C, and KEP10). The results showed a two- to three-day rapid phage clearance, which fits a two-compartment model.

Original languageEnglish
Pages (from-to)301-304
Number of pages4
JournalMicrobiology and Immunology
Volume53
Issue number5
DOIs
Publication statusPublished - May 2009

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Bacteriophages
Therapeutics
Bacteria
Pharmaceutical Preparations

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Uchiyama, Jumpei ; Maeda, Yoshihiro ; Takemura, Iyo ; Chess-Williams, Russ ; Wakiguchi, Hiroshi ; Matsuzaki, Shigenobu. / Blood kinetics of four intraperitoneally administered therapeutic candidate bacteriophages in healthy and neutropenic mice. In: Microbiology and Immunology. 2009 ; Vol. 53, No. 5. pp. 301-304.
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Blood kinetics of four intraperitoneally administered therapeutic candidate bacteriophages in healthy and neutropenic mice. / Uchiyama, Jumpei; Maeda, Yoshihiro; Takemura, Iyo; Chess-Williams, Russ; Wakiguchi, Hiroshi; Matsuzaki, Shigenobu.

In: Microbiology and Immunology, Vol. 53, No. 5, 05.2009, p. 301-304.

Research output: Contribution to journalArticleResearchpeer-review

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