TY - JOUR
T1 - Blood kinetics of four intraperitoneally administered therapeutic candidate bacteriophages in healthy and neutropenic mice
AU - Uchiyama, Jumpei
AU - Maeda, Yoshihiro
AU - Takemura, Iyo
AU - Chess-Williams, Russ
AU - Wakiguchi, Hiroshi
AU - Matsuzaki, Shigenobu
PY - 2009/5
Y1 - 2009/5
N2 - Due to multiple-drug resistant bacteria, phage therapy is being revisited. Although most animal experiments focus on therapeutic efficacy, the blood clearance kinetics of phages have not been well described. For further development of an efficient therapeutic strategy, information on phage blood kinetics is important. In this study, time-course concentration changes in peripheral blood of healthy and neutropenic mice were measured using four therapeutic phages (φMR11, KPP10, φEF24C, and KEP10). The results showed a two- to three-day rapid phage clearance, which fits a two-compartment model.
AB - Due to multiple-drug resistant bacteria, phage therapy is being revisited. Although most animal experiments focus on therapeutic efficacy, the blood clearance kinetics of phages have not been well described. For further development of an efficient therapeutic strategy, information on phage blood kinetics is important. In this study, time-course concentration changes in peripheral blood of healthy and neutropenic mice were measured using four therapeutic phages (φMR11, KPP10, φEF24C, and KEP10). The results showed a two- to three-day rapid phage clearance, which fits a two-compartment model.
UR - http://www.scopus.com/inward/record.url?scp=66849125684&partnerID=8YFLogxK
U2 - 10.1111/j.1348-0421.2009.00125.x
DO - 10.1111/j.1348-0421.2009.00125.x
M3 - Article
C2 - 19457172
AN - SCOPUS:66849125684
SN - 0385-5600
VL - 53
SP - 301
EP - 304
JO - Microbiology and Immunology
JF - Microbiology and Immunology
IS - 5
ER -