Autism in Toddlers Born Very Preterm

Margo Anne Pritchard, Therese de Dassel, Elaine Beller, Fiona Bogossian, Linda Johnston, Jessica Paynter, Santo Russo, James Scott

    Research output: Contribution to journalArticleResearchpeer-review

    20 Citations (Scopus)

    Abstract

    OBJECTIVE: This study aimed to determine the prevalence of autism spectrum disorder (ASD) by using the Autism Diagnostic Observation Schedule-Generic (ADOS-G) classifications in children born very preterm during their toddler years. METHODS: Two birth cohorts of toddlers (2 and 4 years old) each recruited over 12 months and born at <29 weeks' gestation were administered the Modified Checklist of Autism in Toddlers-Follow-up Interview (M-CHAT-FI) screen, the ADOS-G, and developmental assessments. The ADOS-G was conducted on toddlers with M-CHAT-FI-positive screens. RESULTS: Data were available on 88% (169/192) of children. In total, 22 (13%) toddlers screened positive and 3 (1.8%) were confirmed diagnostically with ASD. These 3 cases reached the highest ADOS-G threshold classification of autism. All but 1 child who scored below the ADOS-G thresholds (11/12) demonstrated some difficulty with social communication. Risk was significantly increased for co-occurring neurodevelopmental problems in 21 of the 22 positive-screen ASD cases. Adaptive behavior (P < .001) was the only co-occurring factor independently predictive of ASD in toddlers. CONCLUSIONS: Children born very preterm are at increased risk of ASD. By using the ADOS-G, we found a lower incidence of ASD in children born at <29 weeks' gestation compared with previous studies. Children who screened positive for ASD on the M-CHAT-FI had developmental delays consistent with subthreshold communication impairment.

    Original languageEnglish
    Article numbere20151949
    Number of pages8
    JournalPediatrics
    Volume137
    Issue number2
    DOIs
    Publication statusPublished - Feb 2016

    Cite this

    Pritchard, M. A., de Dassel, T., Beller, E., Bogossian, F., Johnston, L., Paynter, J., ... Scott, J. (2016). Autism in Toddlers Born Very Preterm. Pediatrics, 137(2), [e20151949]. https://doi.org/10.1542/peds.2015-1949
    Pritchard, Margo Anne ; de Dassel, Therese ; Beller, Elaine ; Bogossian, Fiona ; Johnston, Linda ; Paynter, Jessica ; Russo, Santo ; Scott, James. / Autism in Toddlers Born Very Preterm. In: Pediatrics. 2016 ; Vol. 137, No. 2.
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    abstract = "OBJECTIVE: This study aimed to determine the prevalence of autism spectrum disorder (ASD) by using the Autism Diagnostic Observation Schedule-Generic (ADOS-G) classifications in children born very preterm during their toddler years. METHODS: Two birth cohorts of toddlers (2 and 4 years old) each recruited over 12 months and born at <29 weeks' gestation were administered the Modified Checklist of Autism in Toddlers-Follow-up Interview (M-CHAT-FI) screen, the ADOS-G, and developmental assessments. The ADOS-G was conducted on toddlers with M-CHAT-FI-positive screens. RESULTS: Data were available on 88{\%} (169/192) of children. In total, 22 (13{\%}) toddlers screened positive and 3 (1.8{\%}) were confirmed diagnostically with ASD. These 3 cases reached the highest ADOS-G threshold classification of autism. All but 1 child who scored below the ADOS-G thresholds (11/12) demonstrated some difficulty with social communication. Risk was significantly increased for co-occurring neurodevelopmental problems in 21 of the 22 positive-screen ASD cases. Adaptive behavior (P < .001) was the only co-occurring factor independently predictive of ASD in toddlers. CONCLUSIONS: Children born very preterm are at increased risk of ASD. By using the ADOS-G, we found a lower incidence of ASD in children born at <29 weeks' gestation compared with previous studies. Children who screened positive for ASD on the M-CHAT-FI had developmental delays consistent with subthreshold communication impairment.",
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    Pritchard, MA, de Dassel, T, Beller, E, Bogossian, F, Johnston, L, Paynter, J, Russo, S & Scott, J 2016, 'Autism in Toddlers Born Very Preterm' Pediatrics, vol. 137, no. 2, e20151949. https://doi.org/10.1542/peds.2015-1949

    Autism in Toddlers Born Very Preterm. / Pritchard, Margo Anne; de Dassel, Therese; Beller, Elaine; Bogossian, Fiona; Johnston, Linda; Paynter, Jessica; Russo, Santo; Scott, James.

    In: Pediatrics, Vol. 137, No. 2, e20151949, 02.2016.

    Research output: Contribution to journalArticleResearchpeer-review

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    T1 - Autism in Toddlers Born Very Preterm

    AU - Pritchard, Margo Anne

    AU - de Dassel, Therese

    AU - Beller, Elaine

    AU - Bogossian, Fiona

    AU - Johnston, Linda

    AU - Paynter, Jessica

    AU - Russo, Santo

    AU - Scott, James

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    N2 - OBJECTIVE: This study aimed to determine the prevalence of autism spectrum disorder (ASD) by using the Autism Diagnostic Observation Schedule-Generic (ADOS-G) classifications in children born very preterm during their toddler years. METHODS: Two birth cohorts of toddlers (2 and 4 years old) each recruited over 12 months and born at <29 weeks' gestation were administered the Modified Checklist of Autism in Toddlers-Follow-up Interview (M-CHAT-FI) screen, the ADOS-G, and developmental assessments. The ADOS-G was conducted on toddlers with M-CHAT-FI-positive screens. RESULTS: Data were available on 88% (169/192) of children. In total, 22 (13%) toddlers screened positive and 3 (1.8%) were confirmed diagnostically with ASD. These 3 cases reached the highest ADOS-G threshold classification of autism. All but 1 child who scored below the ADOS-G thresholds (11/12) demonstrated some difficulty with social communication. Risk was significantly increased for co-occurring neurodevelopmental problems in 21 of the 22 positive-screen ASD cases. Adaptive behavior (P < .001) was the only co-occurring factor independently predictive of ASD in toddlers. CONCLUSIONS: Children born very preterm are at increased risk of ASD. By using the ADOS-G, we found a lower incidence of ASD in children born at <29 weeks' gestation compared with previous studies. Children who screened positive for ASD on the M-CHAT-FI had developmental delays consistent with subthreshold communication impairment.

    AB - OBJECTIVE: This study aimed to determine the prevalence of autism spectrum disorder (ASD) by using the Autism Diagnostic Observation Schedule-Generic (ADOS-G) classifications in children born very preterm during their toddler years. METHODS: Two birth cohorts of toddlers (2 and 4 years old) each recruited over 12 months and born at <29 weeks' gestation were administered the Modified Checklist of Autism in Toddlers-Follow-up Interview (M-CHAT-FI) screen, the ADOS-G, and developmental assessments. The ADOS-G was conducted on toddlers with M-CHAT-FI-positive screens. RESULTS: Data were available on 88% (169/192) of children. In total, 22 (13%) toddlers screened positive and 3 (1.8%) were confirmed diagnostically with ASD. These 3 cases reached the highest ADOS-G threshold classification of autism. All but 1 child who scored below the ADOS-G thresholds (11/12) demonstrated some difficulty with social communication. Risk was significantly increased for co-occurring neurodevelopmental problems in 21 of the 22 positive-screen ASD cases. Adaptive behavior (P < .001) was the only co-occurring factor independently predictive of ASD in toddlers. CONCLUSIONS: Children born very preterm are at increased risk of ASD. By using the ADOS-G, we found a lower incidence of ASD in children born at <29 weeks' gestation compared with previous studies. Children who screened positive for ASD on the M-CHAT-FI had developmental delays consistent with subthreshold communication impairment.

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    Pritchard MA, de Dassel T, Beller E, Bogossian F, Johnston L, Paynter J et al. Autism in Toddlers Born Very Preterm. Pediatrics. 2016 Feb;137(2). e20151949. https://doi.org/10.1542/peds.2015-1949