Attenuation of sensory afferent nerve firing by brefeldin-A in an ex vivo mouse bladder model

Valerie M. Collins; Christopher R. Chapple; Neil G. McKay; Donna J Sellers; David Grundy

doi:10.1016/S1569-9056(10)60131-5

Attenuation of sensory afferent nerve firing by brefeldin-A in an ex vivo mouse bladder model

Valerie M. Collins, Christopher R. Chapple, Neil G. McKay, Donna J Sellers, David Grundy

Research output: Contribution to journal › Meeting Abstract › Research

Abstract

Urinary urgency is the key sensory symptom of overactive bladder syndrome (OABS). In recent years, injection of botulinum toxin type A (BoNT/A) into the bladder has proved to be an effective way of treating urgency in patients with OABS.
However, the underlying mechanism of action of BoNT/A is unclear. It has been suggested that the efficacy of BoNT/A may
depend on inhibition of vesicular release of neurotransmitters and mediators from suburothelial nerves and/or the urothelium.

Original language	English
Article number	126
Pages (from-to)	72-72
Number of pages	1
Journal	European Urology, Supplements
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/S1569-9056(10)60131-5
Publication status	Published - 2010
Externally published	Yes

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abstract = "Urinary urgency is the key sensory symptom of overactive bladder syndrome (OABS). In recent years, injection of botulinum toxin type A (BoNT/A) into the bladder has proved to be an effective way of treating urgency in patients with OABS.However, the underlying mechanism of action of BoNT/A is unclear. It has been suggested that the efficacy of BoNT/A maydepend on inhibition of vesicular release of neurotransmitters and mediators from suburothelial nerves and/or the urothelium.",

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AU - Collins, Valerie M.

AU - Chapple, Christopher R.

AU - McKay, Neil G.

AU - Sellers, Donna J

AU - Grundy, David

PY - 2010

Y1 - 2010

N2 - Urinary urgency is the key sensory symptom of overactive bladder syndrome (OABS). In recent years, injection of botulinum toxin type A (BoNT/A) into the bladder has proved to be an effective way of treating urgency in patients with OABS.However, the underlying mechanism of action of BoNT/A is unclear. It has been suggested that the efficacy of BoNT/A maydepend on inhibition of vesicular release of neurotransmitters and mediators from suburothelial nerves and/or the urothelium.

AB - Urinary urgency is the key sensory symptom of overactive bladder syndrome (OABS). In recent years, injection of botulinum toxin type A (BoNT/A) into the bladder has proved to be an effective way of treating urgency in patients with OABS.However, the underlying mechanism of action of BoNT/A is unclear. It has been suggested that the efficacy of BoNT/A maydepend on inhibition of vesicular release of neurotransmitters and mediators from suburothelial nerves and/or the urothelium.

U2 - 10.1016/S1569-9056(10)60131-5

DO - 10.1016/S1569-9056(10)60131-5

M3 - Meeting Abstract

SN - 1569-9056

VL - 9

SP - 72

EP - 72

JO - European Urology, Supplements

JF - European Urology, Supplements

IS - 2

M1 - 126

ER -

Attenuation of sensory afferent nerve firing by brefeldin-A in an ex vivo mouse bladder model

Abstract

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