Attenuation of sensory afferent nerve firing by brefeldin-A in an ex vivo mouse bladder model

Valerie M. Collins, Christopher R. Chapple, Neil G. McKay, Donna J Sellers, David Grundy

Research output: Contribution to journalMeeting AbstractResearch


Urinary urgency is the key sensory symptom of overactive bladder syndrome (OABS). In recent years, injection of botulinum toxin type A (BoNT/A) into the bladder has proved to be an effective way of treating urgency in patients with OABS.
However, the underlying mechanism of action of BoNT/A is unclear. It has been suggested that the efficacy of BoNT/A may
depend on inhibition of vesicular release of neurotransmitters and mediators from suburothelial nerves and/or the urothelium.
Original languageEnglish
Article number126
Pages (from-to)72-72
Number of pages1
JournalEuropean Urology, Supplements
Issue number2
Publication statusPublished - 2010
Externally publishedYes


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