Attenuation of sensory afferent nerve firing by brefeldin-A in an ex vivo mouse bladder model

Valerie M. Collins, Christopher R. Chapple, Neil G. McKay, Donna J Sellers, David Grundy

Research output: Contribution to journalMeeting AbstractResearch

Abstract

Urinary urgency is the key sensory symptom of overactive bladder syndrome (OABS). In recent years, injection of botulinum toxin type A (BoNT/A) into the bladder has proved to be an effective way of treating urgency in patients with OABS.
However, the underlying mechanism of action of BoNT/A is unclear. It has been suggested that the efficacy of BoNT/A may
depend on inhibition of vesicular release of neurotransmitters and mediators from suburothelial nerves and/or the urothelium.
Original languageEnglish
Article number126
Pages (from-to)72-72
Number of pages1
JournalEuropean Urology, Supplements
Volume9
Issue number2
DOIs
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Brefeldin A
Type A Botulinum Toxins
Overactive Urinary Bladder
Urinary Bladder
Urothelium
Neurotransmitter Agents
Injections

Cite this

Collins, Valerie M. ; Chapple, Christopher R. ; McKay, Neil G. ; Sellers, Donna J ; Grundy, David. / Attenuation of sensory afferent nerve firing by brefeldin-A in an ex vivo mouse bladder model. In: European Urology, Supplements. 2010 ; Vol. 9, No. 2. pp. 72-72.
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author = "Collins, {Valerie M.} and Chapple, {Christopher R.} and McKay, {Neil G.} and Sellers, {Donna J} and David Grundy",
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Attenuation of sensory afferent nerve firing by brefeldin-A in an ex vivo mouse bladder model. / Collins, Valerie M.; Chapple, Christopher R.; McKay, Neil G.; Sellers, Donna J; Grundy, David.

In: European Urology, Supplements, Vol. 9, No. 2, 126, 2010, p. 72-72.

Research output: Contribution to journalMeeting AbstractResearch

TY - JOUR

T1 - Attenuation of sensory afferent nerve firing by brefeldin-A in an ex vivo mouse bladder model

AU - Collins, Valerie M.

AU - Chapple, Christopher R.

AU - McKay, Neil G.

AU - Sellers, Donna J

AU - Grundy, David

PY - 2010

Y1 - 2010

N2 - Urinary urgency is the key sensory symptom of overactive bladder syndrome (OABS). In recent years, injection of botulinum toxin type A (BoNT/A) into the bladder has proved to be an effective way of treating urgency in patients with OABS.However, the underlying mechanism of action of BoNT/A is unclear. It has been suggested that the efficacy of BoNT/A maydepend on inhibition of vesicular release of neurotransmitters and mediators from suburothelial nerves and/or the urothelium.

AB - Urinary urgency is the key sensory symptom of overactive bladder syndrome (OABS). In recent years, injection of botulinum toxin type A (BoNT/A) into the bladder has proved to be an effective way of treating urgency in patients with OABS.However, the underlying mechanism of action of BoNT/A is unclear. It has been suggested that the efficacy of BoNT/A maydepend on inhibition of vesicular release of neurotransmitters and mediators from suburothelial nerves and/or the urothelium.

U2 - 10.1016/S1569-9056(10)60131-5

DO - 10.1016/S1569-9056(10)60131-5

M3 - Meeting Abstract

VL - 9

SP - 72

EP - 72

JO - European Urology, Supplements

JF - European Urology, Supplements

SN - 1569-9056

IS - 2

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ER -