Association of androgen receptor, prostate-specific antigen, and cyp19 gene polymorphisms with prostate carcinoma and benign prostatic hyperplasia in a north Indian population

Abha Soni; Anju Bansal; Ashwani Kumar Mishra; Jyotsna Batra; Laishram Chandreshwor Singh; Anurupa Chakraborty; Dhirendra Singh Yadav; Nayan K. Mohanty; Sunita Saxena

doi:10.1089/gtmb.2011.0322

Association of androgen receptor, prostate-specific antigen, and cyp19 gene polymorphisms with prostate carcinoma and benign prostatic hyperplasia in a north Indian population

Abha Soni, Anju Bansal, Ashwani Kumar Mishra, Jyotsna Batra, Laishram Chandreshwor Singh, Anurupa Chakraborty, Dhirendra Singh Yadav, Nayan K. Mohanty, Sunita Saxena^*

^*Corresponding author for this work

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Abstract

The genes involved in androgen pathway and metabolism have been reported to contribute considerably to prostate carcinoma (CaP) risk. The present study investigated the association of androgen receptor (AR), prostate-specific antigen (PSA or KLK3), and cytochrome P450 (CYP19) gene polymorphisms in CaP (n=105) and benign prostatic hyperplasia (BPH) (n=120) in comparison to normal healthy controls (n=106) in an Indian population. We also evaluated the functional consequences of these gene variants on AR and PSA mRNA expression. Significant association of short AR CAG repeats (≤24) with risk of CaP (odds ratios [OR]=2.98, p0.05). PSA G-158A SNP was found to be significantly associated with risk of CaP (AA: OR=2.68, p=0.016 and GA: OR=2.07, p=0.018) p-trend 0.031 and BPH (AA: OR=3.46, p

Original language	English
Pages (from-to)	835-840
Number of pages	6
Journal	Genetic Testing and Molecular Biomarkers
Volume	16
Issue number	8
DOIs	https://doi.org/10.1089/gtmb.2011.0322
Publication status	Published - 1 Aug 2012
Externally published	Yes

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Soni, A., Bansal, A., Mishra, A. K., Batra, J., Singh, L. C., Chakraborty, A., Yadav, D. S., Mohanty, N. K., & Saxena, S. (2012). Association of androgen receptor, prostate-specific antigen, and cyp19 gene polymorphisms with prostate carcinoma and benign prostatic hyperplasia in a north Indian population. Genetic Testing and Molecular Biomarkers, 16(8), 835-840. https://doi.org/10.1089/gtmb.2011.0322

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title = "Association of androgen receptor, prostate-specific antigen, and cyp19 gene polymorphisms with prostate carcinoma and benign prostatic hyperplasia in a north Indian population",

abstract = "The genes involved in androgen pathway and metabolism have been reported to contribute considerably to prostate carcinoma (CaP) risk. The present study investigated the association of androgen receptor (AR), prostate-specific antigen (PSA or KLK3), and cytochrome P450 (CYP19) gene polymorphisms in CaP (n=105) and benign prostatic hyperplasia (BPH) (n=120) in comparison to normal healthy controls (n=106) in an Indian population. We also evaluated the functional consequences of these gene variants on AR and PSA mRNA expression. Significant association of short AR CAG repeats (≤24) with risk of CaP (odds ratios [OR]=2.98, p0.05). PSA G-158A SNP was found to be significantly associated with risk of CaP (AA: OR=2.68, p=0.016 and GA: OR=2.07, p=0.018) p-trend 0.031 and BPH (AA: OR=3.46, p",

author = "Abha Soni and Anju Bansal and Mishra, {Ashwani Kumar} and Jyotsna Batra and Singh, {Laishram Chandreshwor} and Anurupa Chakraborty and Yadav, {Dhirendra Singh} and Mohanty, {Nayan K.} and Sunita Saxena",

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Soni, A, Bansal, A, Mishra, AK, Batra, J, Singh, LC, Chakraborty, A, Yadav, DS, Mohanty, NK & Saxena, S 2012, 'Association of androgen receptor, prostate-specific antigen, and cyp19 gene polymorphisms with prostate carcinoma and benign prostatic hyperplasia in a north Indian population', Genetic Testing and Molecular Biomarkers, vol. 16, no. 8, pp. 835-840. https://doi.org/10.1089/gtmb.2011.0322

Association of androgen receptor, prostate-specific antigen, and cyp19 gene polymorphisms with prostate carcinoma and benign prostatic hyperplasia in a north Indian population. / Soni, Abha; Bansal, Anju; Mishra, Ashwani Kumar et al.
In: Genetic Testing and Molecular Biomarkers, Vol. 16, No. 8, 01.08.2012, p. 835-840.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Mishra, Ashwani Kumar

AU - Batra, Jyotsna

AU - Singh, Laishram Chandreshwor

AU - Chakraborty, Anurupa

AU - Yadav, Dhirendra Singh

AU - Mohanty, Nayan K.

AU - Saxena, Sunita

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Association of androgen receptor, prostate-specific antigen, and cyp19 gene polymorphisms with prostate carcinoma and benign prostatic hyperplasia in a north Indian population

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