TY - JOUR
T1 - Association Between a Low-Carbohydrate Diet, Glycemic Control, and Quality of Life in Australian Adults Living With Type 1 Diabetes: A Pilot Study
AU - Paul, Janine
AU - Jani, Rati
AU - Jones, Mark
AU - Davoren, Peter
AU - Knight-Agarwal, Catherine
N1 - Funding Information:
The authors thank all the patients who participated in the study and diabetes educator nurses: David Irvine (DI) and Hanny Fitzgerald (HF) for assistance with participant recruitment, data collection, and qualitative data analysis. Thank you to Dexcom (study ID OUS-2019-042) and the Gold Coast Hospital and Health Service SERTA Committee (reference ID 345) for providing the study resources. The Gold Coast University Hospital library staff members are also acknowledged for their support throughout the study. All authors contributed to the study design. M.J. analysed the data and provided statistical advice. J.P. authored the first version of the manuscript. All authors reviewed the manuscript and further revisions were made by J.P. The authors have no multiplicity of interest to disclose. Data are available on request from the corresponding author. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.
Publisher Copyright:
© 2022 AACE
PY - 2022/11
Y1 - 2022/11
N2 - Objective: To examine if there is an association between a low-carbohydrate diet (LCD), glycemic control, and quality of life (QoL) in Australian adults with type 1 diabetes. Methods: This single-group, pre-post, mixed methods (quantitative and qualitative) study was conducted in an outpatient tertiary hospital. Eligible participants were those aged ≥18 years, with type 1 diabetes for ≥1 year, and using multiple daily insulin injections. Participants followed a 12-week individualized LCD (<100 g/d). Daily glucose levels were monitored using a continuous glucose monitor. Glycated hemoglobin (HbA1c) and QoL were measured preintervention and postintervention. A post-hoc exploratory regression analysis determined whether changes in carbohydrate intake was associated with changes in HbA1c and QoL. Qualitative data collected postintervention explored participants’ perceptions relating to a LCD, glycemic control, and QoL. Results: Participants (n = 22) completed the 12-week LCD intervention. An LCD provided a statistically, significant improvement in HbA1c 0.83% (95% CI 0.32%-1.33%), P = .003 but did not impact QoL: estimated change 1.14 units (95% CI: −5.34 to 7.61); P = .72. The post-hoc exploratory regression analysis showed that participants with poorer baseline glycemic control were more likely to respond to an LCD resulting in significant reductions in HbA1c. Participant perceptions relating to the study variables were mixed. Conclusions: An LCD (<100 g/d) is a potentially effective and safe strategy to improve glycemic control without negatively effecting QoL in Australia adults with type 1 diabetes.
AB - Objective: To examine if there is an association between a low-carbohydrate diet (LCD), glycemic control, and quality of life (QoL) in Australian adults with type 1 diabetes. Methods: This single-group, pre-post, mixed methods (quantitative and qualitative) study was conducted in an outpatient tertiary hospital. Eligible participants were those aged ≥18 years, with type 1 diabetes for ≥1 year, and using multiple daily insulin injections. Participants followed a 12-week individualized LCD (<100 g/d). Daily glucose levels were monitored using a continuous glucose monitor. Glycated hemoglobin (HbA1c) and QoL were measured preintervention and postintervention. A post-hoc exploratory regression analysis determined whether changes in carbohydrate intake was associated with changes in HbA1c and QoL. Qualitative data collected postintervention explored participants’ perceptions relating to a LCD, glycemic control, and QoL. Results: Participants (n = 22) completed the 12-week LCD intervention. An LCD provided a statistically, significant improvement in HbA1c 0.83% (95% CI 0.32%-1.33%), P = .003 but did not impact QoL: estimated change 1.14 units (95% CI: −5.34 to 7.61); P = .72. The post-hoc exploratory regression analysis showed that participants with poorer baseline glycemic control were more likely to respond to an LCD resulting in significant reductions in HbA1c. Participant perceptions relating to the study variables were mixed. Conclusions: An LCD (<100 g/d) is a potentially effective and safe strategy to improve glycemic control without negatively effecting QoL in Australia adults with type 1 diabetes.
UR - http://www.scopus.com/inward/record.url?scp=85137056776&partnerID=8YFLogxK
U2 - 10.1016/j.eprac.2022.08.003
DO - 10.1016/j.eprac.2022.08.003
M3 - Article
C2 - 35963507
AN - SCOPUS:85137056776
SN - 1530-891X
VL - 28
SP - 1125
EP - 1131
JO - Endocrine Practice
JF - Endocrine Practice
IS - 11
ER -