Assessment of the hemorheological profile of koala and echidna

Oguz K. Baskurt, Sonya Marshall-Gradisnik, Michael Pyne, Michael Simmonds, Ekua Brenu, Rhys Christy, Herbert J. Meiselman

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7 Citations (Scopus)

Abstract

Koala, a marsupial, and echidna, a monotreme, are mammals native to Australia. Blood viscosity (62.5-1250 s-1), red blood cell (RBC) deformability, RBC aggregation, aggregability and surface charge, and hematological parameters were measured in blood samples from six koalas and six echidnas and compared to adult human blood. Koala had the largest RBC mean cell volume (107.7±2.6 fl) compared to echidna (81.3±2.6 fl) and humans (88.4±1.2 fl). Echidna blood exhibited the highest viscosity over the entire range of shear rates. Echidna RBC were significantly less deformable than koala RBC but more deformable than human RBC. Echidna RBC had significantly lower aggregability (i.e., aggregation in standardized dextran medium) than koala or human RBC, while aggregation in autologous plasma was similar for the three species. Erythrocyte surface charge as indexed by RBC electrophoretic mobility was similar for human and echidna cells but was 40% lower for koala RBC. Data obtained during this preliminary study indicate that koala and echidna have distinct hemorheological characteristics; investigation of these properties may reveal patterns relevant to specific behavioral and physiological features of these animals.

Original languageEnglish
Pages (from-to)110-117
Number of pages8
JournalZoology
Volume113
Issue number2
DOIs
Publication statusPublished - Mar 2010

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Tachyglossidae
erythrocytes
blood
blood viscosity
dextran
Metatheria
shears
viscosity

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Baskurt, O. K., Marshall-Gradisnik, S., Pyne, M., Simmonds, M., Brenu, E., Christy, R., & Meiselman, H. J. (2010). Assessment of the hemorheological profile of koala and echidna. Zoology, 113(2), 110-117. https://doi.org/10.1016/j.zool.2009.07.003
Baskurt, Oguz K. ; Marshall-Gradisnik, Sonya ; Pyne, Michael ; Simmonds, Michael ; Brenu, Ekua ; Christy, Rhys ; Meiselman, Herbert J. / Assessment of the hemorheological profile of koala and echidna. In: Zoology. 2010 ; Vol. 113, No. 2. pp. 110-117.
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Baskurt, OK, Marshall-Gradisnik, S, Pyne, M, Simmonds, M, Brenu, E, Christy, R & Meiselman, HJ 2010, 'Assessment of the hemorheological profile of koala and echidna' Zoology, vol. 113, no. 2, pp. 110-117. https://doi.org/10.1016/j.zool.2009.07.003

Assessment of the hemorheological profile of koala and echidna. / Baskurt, Oguz K.; Marshall-Gradisnik, Sonya; Pyne, Michael; Simmonds, Michael; Brenu, Ekua; Christy, Rhys; Meiselman, Herbert J.

In: Zoology, Vol. 113, No. 2, 03.2010, p. 110-117.

Research output: Contribution to journalArticleResearchpeer-review

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Baskurt OK, Marshall-Gradisnik S, Pyne M, Simmonds M, Brenu E, Christy R et al. Assessment of the hemorheological profile of koala and echidna. Zoology. 2010 Mar;113(2):110-117. https://doi.org/10.1016/j.zool.2009.07.003