Abstract
There have been several reports demonstrating the potential of virus-mediated gene delivery for use in treating congenital retinal degenerations (Bennett and Maguire, 2000; Acland et al., 2001; Campochiaro et al., 2002; Narfstrom et al., 2002). A recent report on the restoration of vision to Briard dogs marked the first successful gene therapy for blindness in a large animal model, bringing the possibility of a human retinal gene therapy trial closer (Bennett and Maguire, 2000; Narfstrom et al., 2002). We wished to pursue this potential, by developing a successful gene therapy protocol for the treatment of retinal degeneration in a small animal model. Once established, this small animal model could be used to assess the clinical benefits and limitations of using gene therapy in treating congenital retinal degeneration.
Original language | English |
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Title of host publication | Retinal Degenerations: Mechanisms and Experimental Therapy |
Subtitle of host publication | Proceedings of the X International Symposium on Retinal Degeneration, held September 30-0ctober 5, 2002, in Burgenstock, Switzerland |
Editors | Matthew M. LaVail, Joe G. Hollyfield, Robert E. Anderson |
Place of Publication | Boston |
Publisher | Springer |
Chapter | 55 |
Pages | 431-438 |
Number of pages | 8 |
ISBN (Electronic) | 978-1-4615-0067-4 |
ISBN (Print) | 978-1-4613-4909-9 |
DOIs | |
Publication status | Published - 1 Dec 2003 |
Externally published | Yes |
Event | RD 2002: 10th International Symposium on Retinal Degenerations - Burgenstock, Switzerland Duration: 30 Sep 2002 → 5 Oct 2002 |
Publication series
Name | Advances in Experimental Medicine and Biology |
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Publisher | Springer |
Volume | 533 |
ISSN (Print) | 0065-2598 |
Conference
Conference | RD 2002: 10th International Symposium on Retinal Degenerations |
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Country | Switzerland |
City | Burgenstock |
Period | 30/09/02 → 5/10/02 |