Assessing the risk of epidemic dropsy from black salve use

Andrew Croaker, Graham J. King, John H. Pyne, Shailendra Anoopkumar-Dukie, Lei Liu

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Epidemic dropsy is a potentially life-threatening condition resulting from the ingestion of argemone oil derived from the seeds of Argemone mexicana Linn. Exposure to argemone oil is usually inadvertent, arising from mustard cooking oil adulteration. Sanguinarine, an alkaloid present in argemone oil, has been postulated as a causative agent with the severity of epidemic dropsy correlating with plasma sanguinarine levels. Cases of epidemic dropsy have also been reported following the topical application of argemone containing massage oil. Black salve, a topical skin cancer therapy also contains sanguinarine, but at significantly higher concentrations than that reported for contaminated massage oil. Although not reported to date, a theoretical risk therefore exists of black salve inducing epidemic dropsy. This literature review explores the presentation and pathophysiology of epidemic dropsy and assesses the risk of it being induced by black salve.

Original languageEnglish
Pages (from-to)1274-1281
Number of pages8
JournalJournal of Applied Toxicology
Volume38
Issue number10
DOIs
Publication statusPublished - 1 Oct 2018
Externally publishedYes

Fingerprint

Ointments
Edema
Argemone
Oils
Massage
Cooking
Alkaloids
Seed
Skin
Plasmas
Skin Neoplasms
Seeds
Eating
argemone oil
sanguinarine
Therapeutics

Cite this

Croaker, A., King, G. J., Pyne, J. H., Anoopkumar-Dukie, S., & Liu, L. (2018). Assessing the risk of epidemic dropsy from black salve use. Journal of Applied Toxicology, 38(10), 1274-1281. https://doi.org/10.1002/jat.3619
Croaker, Andrew ; King, Graham J. ; Pyne, John H. ; Anoopkumar-Dukie, Shailendra ; Liu, Lei. / Assessing the risk of epidemic dropsy from black salve use. In: Journal of Applied Toxicology. 2018 ; Vol. 38, No. 10. pp. 1274-1281.
@article{f6cd76369e0a44e2b44c12bc09b32dae,
title = "Assessing the risk of epidemic dropsy from black salve use",
abstract = "Epidemic dropsy is a potentially life-threatening condition resulting from the ingestion of argemone oil derived from the seeds of Argemone mexicana Linn. Exposure to argemone oil is usually inadvertent, arising from mustard cooking oil adulteration. Sanguinarine, an alkaloid present in argemone oil, has been postulated as a causative agent with the severity of epidemic dropsy correlating with plasma sanguinarine levels. Cases of epidemic dropsy have also been reported following the topical application of argemone containing massage oil. Black salve, a topical skin cancer therapy also contains sanguinarine, but at significantly higher concentrations than that reported for contaminated massage oil. Although not reported to date, a theoretical risk therefore exists of black salve inducing epidemic dropsy. This literature review explores the presentation and pathophysiology of epidemic dropsy and assesses the risk of it being induced by black salve.",
author = "Andrew Croaker and King, {Graham J.} and Pyne, {John H.} and Shailendra Anoopkumar-Dukie and Lei Liu",
note = "Copyright {\circledC} 2018 John Wiley & Sons, Ltd.",
year = "2018",
month = "10",
day = "1",
doi = "10.1002/jat.3619",
language = "English",
volume = "38",
pages = "1274--1281",
journal = "Journal of Applied Toxicology",
issn = "0260-437X",
publisher = "John Wiley & Sons",
number = "10",

}

Croaker, A, King, GJ, Pyne, JH, Anoopkumar-Dukie, S & Liu, L 2018, 'Assessing the risk of epidemic dropsy from black salve use' Journal of Applied Toxicology, vol. 38, no. 10, pp. 1274-1281. https://doi.org/10.1002/jat.3619

Assessing the risk of epidemic dropsy from black salve use. / Croaker, Andrew; King, Graham J.; Pyne, John H.; Anoopkumar-Dukie, Shailendra; Liu, Lei.

In: Journal of Applied Toxicology, Vol. 38, No. 10, 01.10.2018, p. 1274-1281.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Assessing the risk of epidemic dropsy from black salve use

AU - Croaker, Andrew

AU - King, Graham J.

AU - Pyne, John H.

AU - Anoopkumar-Dukie, Shailendra

AU - Liu, Lei

N1 - Copyright © 2018 John Wiley & Sons, Ltd.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Epidemic dropsy is a potentially life-threatening condition resulting from the ingestion of argemone oil derived from the seeds of Argemone mexicana Linn. Exposure to argemone oil is usually inadvertent, arising from mustard cooking oil adulteration. Sanguinarine, an alkaloid present in argemone oil, has been postulated as a causative agent with the severity of epidemic dropsy correlating with plasma sanguinarine levels. Cases of epidemic dropsy have also been reported following the topical application of argemone containing massage oil. Black salve, a topical skin cancer therapy also contains sanguinarine, but at significantly higher concentrations than that reported for contaminated massage oil. Although not reported to date, a theoretical risk therefore exists of black salve inducing epidemic dropsy. This literature review explores the presentation and pathophysiology of epidemic dropsy and assesses the risk of it being induced by black salve.

AB - Epidemic dropsy is a potentially life-threatening condition resulting from the ingestion of argemone oil derived from the seeds of Argemone mexicana Linn. Exposure to argemone oil is usually inadvertent, arising from mustard cooking oil adulteration. Sanguinarine, an alkaloid present in argemone oil, has been postulated as a causative agent with the severity of epidemic dropsy correlating with plasma sanguinarine levels. Cases of epidemic dropsy have also been reported following the topical application of argemone containing massage oil. Black salve, a topical skin cancer therapy also contains sanguinarine, but at significantly higher concentrations than that reported for contaminated massage oil. Although not reported to date, a theoretical risk therefore exists of black salve inducing epidemic dropsy. This literature review explores the presentation and pathophysiology of epidemic dropsy and assesses the risk of it being induced by black salve.

UR - http://www.scopus.com/inward/record.url?scp=85044581735&partnerID=8YFLogxK

U2 - 10.1002/jat.3619

DO - 10.1002/jat.3619

M3 - Article

VL - 38

SP - 1274

EP - 1281

JO - Journal of Applied Toxicology

JF - Journal of Applied Toxicology

SN - 0260-437X

IS - 10

ER -

Croaker A, King GJ, Pyne JH, Anoopkumar-Dukie S, Liu L. Assessing the risk of epidemic dropsy from black salve use. Journal of Applied Toxicology. 2018 Oct 1;38(10):1274-1281. https://doi.org/10.1002/jat.3619