Anticoagulation control and prediction of adverse events in patients with atrial fibrillation: A Systematic Review

Yi Wan, Carl Heneghan, Rafael Perera, Nia Roberts, Jennifer Hollowell, Paul Glasziou, Clare Bankhead, Yongyong Xu

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Abstract

Background-To date, there has been no systematic examination of the relationship between international normalized ratio (INR) control measurements and the prediction of adverse events in patients with atrial fibrillation on oral anticoagulation.

Methods and Results-We searched MEDLINE, EMBASE, and Cochrane through January 2008 for studies of atrial fibrillation patients receiving vitamin-K antagonists that reported INR control measures (percentage of time in therapeutic range [TTR] and percentage of INRs in range) and major hemorrhage and thromboembolic events. In total, 47 studies were included from 38 published articles. TTR ranged from 29% to 75%; percentage of INRs ranged from 34% to 84%. From studies reporting both measures, TTR significantly correlated with percentage of INRs in range (P

Conclusions-In atrial fibrillation patients receiving orally administered anticoagulation treatment, TTR and percentage of INRs in range effectively predict INR control. Data from retrospective studies support the use of TTR to accurately predict reductions in adverse events. (Circ Cardiovasc Qual Outcomes. 2008; 1:84-91.)

Original languageEnglish
Pages (from-to)84-91
Number of pages8
JournalCirculation: Cardiovascular Quality and Outcomes
Volume1
Issue number2
DOIs
Publication statusPublished - Nov 2008
Externally publishedYes

Cite this

Wan, Yi ; Heneghan, Carl ; Perera, Rafael ; Roberts, Nia ; Hollowell, Jennifer ; Glasziou, Paul ; Bankhead, Clare ; Xu, Yongyong. / Anticoagulation control and prediction of adverse events in patients with atrial fibrillation : A Systematic Review. In: Circulation: Cardiovascular Quality and Outcomes. 2008 ; Vol. 1, No. 2. pp. 84-91.
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Anticoagulation control and prediction of adverse events in patients with atrial fibrillation : A Systematic Review. / Wan, Yi; Heneghan, Carl; Perera, Rafael; Roberts, Nia; Hollowell, Jennifer; Glasziou, Paul; Bankhead, Clare; Xu, Yongyong.

In: Circulation: Cardiovascular Quality and Outcomes, Vol. 1, No. 2, 11.2008, p. 84-91.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Anticoagulation control and prediction of adverse events in patients with atrial fibrillation

T2 - A Systematic Review

AU - Wan, Yi

AU - Heneghan, Carl

AU - Perera, Rafael

AU - Roberts, Nia

AU - Hollowell, Jennifer

AU - Glasziou, Paul

AU - Bankhead, Clare

AU - Xu, Yongyong

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N2 - Background-To date, there has been no systematic examination of the relationship between international normalized ratio (INR) control measurements and the prediction of adverse events in patients with atrial fibrillation on oral anticoagulation.Methods and Results-We searched MEDLINE, EMBASE, and Cochrane through January 2008 for studies of atrial fibrillation patients receiving vitamin-K antagonists that reported INR control measures (percentage of time in therapeutic range [TTR] and percentage of INRs in range) and major hemorrhage and thromboembolic events. In total, 47 studies were included from 38 published articles. TTR ranged from 29% to 75%; percentage of INRs ranged from 34% to 84%. From studies reporting both measures, TTR significantly correlated with percentage of INRs in range (PConclusions-In atrial fibrillation patients receiving orally administered anticoagulation treatment, TTR and percentage of INRs in range effectively predict INR control. Data from retrospective studies support the use of TTR to accurately predict reductions in adverse events. (Circ Cardiovasc Qual Outcomes. 2008; 1:84-91.)

AB - Background-To date, there has been no systematic examination of the relationship between international normalized ratio (INR) control measurements and the prediction of adverse events in patients with atrial fibrillation on oral anticoagulation.Methods and Results-We searched MEDLINE, EMBASE, and Cochrane through January 2008 for studies of atrial fibrillation patients receiving vitamin-K antagonists that reported INR control measures (percentage of time in therapeutic range [TTR] and percentage of INRs in range) and major hemorrhage and thromboembolic events. In total, 47 studies were included from 38 published articles. TTR ranged from 29% to 75%; percentage of INRs ranged from 34% to 84%. From studies reporting both measures, TTR significantly correlated with percentage of INRs in range (PConclusions-In atrial fibrillation patients receiving orally administered anticoagulation treatment, TTR and percentage of INRs in range effectively predict INR control. Data from retrospective studies support the use of TTR to accurately predict reductions in adverse events. (Circ Cardiovasc Qual Outcomes. 2008; 1:84-91.)

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