Antibiotic therapy for inpatients with community-acquired pneumonia in a developing country

Hieu T. Trinh, Phuong H. Hoang, Magnolia Cardona-Morrell, Hai T. Nguyen, Dinh Hoa Vu, Phuong T.X. Dong, Thao T.B. Cao, Son T. Nguyen, Van T.T. Pham, Le Moss, Kathryn Dinh, Jonathan Dartnell, Huong T.L. Nguyen

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

PURPOSE: The aim of this study was to identify antibiotic prescription patterns for community-acquired pneumonia (CAP) in Vietnam.

METHODS: Medical records for CAP adult patients admitted to 10 hospitals across the country were randomly selected from admission lists during the peak pneumonia season. CAP cases were identified from manual record reviews by clinical pharmacists. Data was collected using a standard data collection tool including patient clinical features on admission, comorbidities, microbiological culture results, and antibiotic regimens. Pneumonia severity was estimated using the CURB-65 score.

RESULTS: A total of 649 medical records for adult patients (55.2% male and 52.3% urban residents, median age 68 years) met the selection criteria for CAP. Pneumonia severity was assessed as mild (64.1% of patients), moderate (23.0%), and severe (9.2%). Antibiotics were most frequently administered intravenously (93.4%) and as combination therapy (dual therapy 54.4%, monotherapy 42.5%, and triple therapy 3.1% of patients) regardless of CAP severity. Third-generation cephalosporins were used most frequently (29.3% as monotherapy and 40.4% as combination therapy). Third-generation cephalosporins were most commonly combined with penicillins and/or quinolones.

CONCLUSIONS: This first nationwide study provides a baseline profile of antibiotic use in the treatment of CAP. Third-generation cephalosporins were widely used for initial empirical management of CAP, often in combination with quinolones, regardless of CAP severity. The study will assist in providing an evidence base to inform new national antibiotic guidelines for CAP management and will contribute locally relevant data for the national master plan addressing antibiotic resistance and the development of educational interventions to improve CAP management.

Original languageEnglish
Pages (from-to)129-136
Number of pages8
JournalPharmacoepidemiology and Drug Safety
Volume24
Issue number2
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Fingerprint

Developing Countries
Inpatients
Pneumonia
Anti-Bacterial Agents
Therapeutics
Cephalosporins
Quinolones
Developing countries
Therapy
Antibiotics
Medical Records
Vietnam
Microbial Drug Resistance
Pharmacists
Penicillins
Patient Selection
Prescriptions
Comorbidity
Guidelines

Cite this

Trinh, Hieu T. ; Hoang, Phuong H. ; Cardona-Morrell, Magnolia ; Nguyen, Hai T. ; Vu, Dinh Hoa ; Dong, Phuong T.X. ; Cao, Thao T.B. ; Nguyen, Son T. ; Pham, Van T.T. ; Moss, Le ; Dinh, Kathryn ; Dartnell, Jonathan ; Nguyen, Huong T.L. / Antibiotic therapy for inpatients with community-acquired pneumonia in a developing country. In: Pharmacoepidemiology and Drug Safety. 2015 ; Vol. 24, No. 2. pp. 129-136.
@article{a256fad04375496d8af8e7bea4aad7cf,
title = "Antibiotic therapy for inpatients with community-acquired pneumonia in a developing country",
abstract = "PURPOSE: The aim of this study was to identify antibiotic prescription patterns for community-acquired pneumonia (CAP) in Vietnam.METHODS: Medical records for CAP adult patients admitted to 10 hospitals across the country were randomly selected from admission lists during the peak pneumonia season. CAP cases were identified from manual record reviews by clinical pharmacists. Data was collected using a standard data collection tool including patient clinical features on admission, comorbidities, microbiological culture results, and antibiotic regimens. Pneumonia severity was estimated using the CURB-65 score.RESULTS: A total of 649 medical records for adult patients (55.2{\%} male and 52.3{\%} urban residents, median age 68 years) met the selection criteria for CAP. Pneumonia severity was assessed as mild (64.1{\%} of patients), moderate (23.0{\%}), and severe (9.2{\%}). Antibiotics were most frequently administered intravenously (93.4{\%}) and as combination therapy (dual therapy 54.4{\%}, monotherapy 42.5{\%}, and triple therapy 3.1{\%} of patients) regardless of CAP severity. Third-generation cephalosporins were used most frequently (29.3{\%} as monotherapy and 40.4{\%} as combination therapy). Third-generation cephalosporins were most commonly combined with penicillins and/or quinolones.CONCLUSIONS: This first nationwide study provides a baseline profile of antibiotic use in the treatment of CAP. Third-generation cephalosporins were widely used for initial empirical management of CAP, often in combination with quinolones, regardless of CAP severity. The study will assist in providing an evidence base to inform new national antibiotic guidelines for CAP management and will contribute locally relevant data for the national master plan addressing antibiotic resistance and the development of educational interventions to improve CAP management.",
author = "Trinh, {Hieu T.} and Hoang, {Phuong H.} and Magnolia Cardona-Morrell and Nguyen, {Hai T.} and Vu, {Dinh Hoa} and Dong, {Phuong T.X.} and Cao, {Thao T.B.} and Nguyen, {Son T.} and Pham, {Van T.T.} and Le Moss and Kathryn Dinh and Jonathan Dartnell and Nguyen, {Huong T.L.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1002/pds.3614",
language = "English",
volume = "24",
pages = "129--136",
journal = "Pharmacoepidemiology and Drug Safety",
issn = "1053-8569",
publisher = "John Wiley & Sons",
number = "2",

}

Trinh, HT, Hoang, PH, Cardona-Morrell, M, Nguyen, HT, Vu, DH, Dong, PTX, Cao, TTB, Nguyen, ST, Pham, VTT, Moss, L, Dinh, K, Dartnell, J & Nguyen, HTL 2015, 'Antibiotic therapy for inpatients with community-acquired pneumonia in a developing country' Pharmacoepidemiology and Drug Safety, vol. 24, no. 2, pp. 129-136. https://doi.org/10.1002/pds.3614

Antibiotic therapy for inpatients with community-acquired pneumonia in a developing country. / Trinh, Hieu T.; Hoang, Phuong H.; Cardona-Morrell, Magnolia; Nguyen, Hai T.; Vu, Dinh Hoa; Dong, Phuong T.X.; Cao, Thao T.B.; Nguyen, Son T.; Pham, Van T.T.; Moss, Le; Dinh, Kathryn; Dartnell, Jonathan; Nguyen, Huong T.L.

In: Pharmacoepidemiology and Drug Safety, Vol. 24, No. 2, 01.01.2015, p. 129-136.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Antibiotic therapy for inpatients with community-acquired pneumonia in a developing country

AU - Trinh, Hieu T.

AU - Hoang, Phuong H.

AU - Cardona-Morrell, Magnolia

AU - Nguyen, Hai T.

AU - Vu, Dinh Hoa

AU - Dong, Phuong T.X.

AU - Cao, Thao T.B.

AU - Nguyen, Son T.

AU - Pham, Van T.T.

AU - Moss, Le

AU - Dinh, Kathryn

AU - Dartnell, Jonathan

AU - Nguyen, Huong T.L.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - PURPOSE: The aim of this study was to identify antibiotic prescription patterns for community-acquired pneumonia (CAP) in Vietnam.METHODS: Medical records for CAP adult patients admitted to 10 hospitals across the country were randomly selected from admission lists during the peak pneumonia season. CAP cases were identified from manual record reviews by clinical pharmacists. Data was collected using a standard data collection tool including patient clinical features on admission, comorbidities, microbiological culture results, and antibiotic regimens. Pneumonia severity was estimated using the CURB-65 score.RESULTS: A total of 649 medical records for adult patients (55.2% male and 52.3% urban residents, median age 68 years) met the selection criteria for CAP. Pneumonia severity was assessed as mild (64.1% of patients), moderate (23.0%), and severe (9.2%). Antibiotics were most frequently administered intravenously (93.4%) and as combination therapy (dual therapy 54.4%, monotherapy 42.5%, and triple therapy 3.1% of patients) regardless of CAP severity. Third-generation cephalosporins were used most frequently (29.3% as monotherapy and 40.4% as combination therapy). Third-generation cephalosporins were most commonly combined with penicillins and/or quinolones.CONCLUSIONS: This first nationwide study provides a baseline profile of antibiotic use in the treatment of CAP. Third-generation cephalosporins were widely used for initial empirical management of CAP, often in combination with quinolones, regardless of CAP severity. The study will assist in providing an evidence base to inform new national antibiotic guidelines for CAP management and will contribute locally relevant data for the national master plan addressing antibiotic resistance and the development of educational interventions to improve CAP management.

AB - PURPOSE: The aim of this study was to identify antibiotic prescription patterns for community-acquired pneumonia (CAP) in Vietnam.METHODS: Medical records for CAP adult patients admitted to 10 hospitals across the country were randomly selected from admission lists during the peak pneumonia season. CAP cases were identified from manual record reviews by clinical pharmacists. Data was collected using a standard data collection tool including patient clinical features on admission, comorbidities, microbiological culture results, and antibiotic regimens. Pneumonia severity was estimated using the CURB-65 score.RESULTS: A total of 649 medical records for adult patients (55.2% male and 52.3% urban residents, median age 68 years) met the selection criteria for CAP. Pneumonia severity was assessed as mild (64.1% of patients), moderate (23.0%), and severe (9.2%). Antibiotics were most frequently administered intravenously (93.4%) and as combination therapy (dual therapy 54.4%, monotherapy 42.5%, and triple therapy 3.1% of patients) regardless of CAP severity. Third-generation cephalosporins were used most frequently (29.3% as monotherapy and 40.4% as combination therapy). Third-generation cephalosporins were most commonly combined with penicillins and/or quinolones.CONCLUSIONS: This first nationwide study provides a baseline profile of antibiotic use in the treatment of CAP. Third-generation cephalosporins were widely used for initial empirical management of CAP, often in combination with quinolones, regardless of CAP severity. The study will assist in providing an evidence base to inform new national antibiotic guidelines for CAP management and will contribute locally relevant data for the national master plan addressing antibiotic resistance and the development of educational interventions to improve CAP management.

UR - http://www.scopus.com/inward/record.url?scp=84921811365&partnerID=8YFLogxK

U2 - 10.1002/pds.3614

DO - 10.1002/pds.3614

M3 - Article

VL - 24

SP - 129

EP - 136

JO - Pharmacoepidemiology and Drug Safety

JF - Pharmacoepidemiology and Drug Safety

SN - 1053-8569

IS - 2

ER -