Analyzing Trophoblast Function Using Cell-Based Assays

Katie L Powell, Anthony W Ashton

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

1 Citation (Scopus)

Abstract

Functional cell-based assays are useful for comparing the effect of a treatment, drug, or condition on cells in culture. Cell lines are a commonly used model to replicate a normal biological process or a pathological condition. Trophoblasts within the placenta are required to perform a variety of functions, which include proliferation, differentiation, migration, and invasion for efficient placentation to occur. These functions are impaired in trophoblasts from preeclamptic pregnancies, and therefore functional cell-based assays can be utilized to measure differences and dissect molecular regulatory pathways.

Original languageEnglish
Title of host publicationPreeclampsia. Methods and Protocols
EditorsPadma Murthi, Cathy Vaillancourt
PublisherSpringer Science + Business Media
Pages233-246
Number of pages14
ISBN (Electronic)978-1-4939-7498-6
ISBN (Print)978-1-4939-7497-9
DOIs
Publication statusPublished - 2018
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1710
ISSN (Print)1064-3745

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  • Cite this

    Powell, K. L., & Ashton, A. W. (2018). Analyzing Trophoblast Function Using Cell-Based Assays. In P. Murthi, & C. Vaillancourt (Eds.), Preeclampsia. Methods and Protocols (pp. 233-246). (Methods in Molecular Biology; Vol. 1710). Springer Science + Business Media. https://doi.org/10.1007/978-1-4939-7498-6_18