Abstract
Functional cell-based assays are useful for comparing the effect of a treatment, drug, or condition on cells in culture. Cell lines are a commonly used model to replicate a normal biological process or a pathological condition. Trophoblasts within the placenta are required to perform a variety of functions, which include proliferation, differentiation, migration, and invasion for efficient placentation to occur. These functions are impaired in trophoblasts from preeclamptic pregnancies, and therefore functional cell-based assays can be utilized to measure differences and dissect molecular regulatory pathways.
| Original language | English |
|---|---|
| Title of host publication | Preeclampsia. Methods and Protocols |
| Editors | Padma Murthi, Cathy Vaillancourt |
| Publisher | Springer Science + Business Media |
| Pages | 233-246 |
| Number of pages | 14 |
| ISBN (Electronic) | 978-1-4939-7498-6 |
| ISBN (Print) | 978-1-4939-7497-9 |
| DOIs | |
| Publication status | Published - 2018 |
| Externally published | Yes |
Publication series
| Name | Methods in Molecular Biology |
|---|---|
| Publisher | Humana Press |
| Volume | 1710 |
| ISSN (Print) | 1064-3745 |
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Analyzing Trophoblast Function Using Cell-Based Assays. / Powell, Katie L; Ashton, Anthony W.
Preeclampsia. Methods and Protocols. ed. / Padma Murthi; Cathy Vaillancourt. Springer Science + Business Media, 2018. p. 233-246 (Methods in Molecular Biology; Vol. 1710).Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review
TY - CHAP
T1 - Analyzing Trophoblast Function Using Cell-Based Assays
AU - Powell, Katie L
AU - Ashton, Anthony W
PY - 2018
Y1 - 2018
N2 - Functional cell-based assays are useful for comparing the effect of a treatment, drug, or condition on cells in culture. Cell lines are a commonly used model to replicate a normal biological process or a pathological condition. Trophoblasts within the placenta are required to perform a variety of functions, which include proliferation, differentiation, migration, and invasion for efficient placentation to occur. These functions are impaired in trophoblasts from preeclamptic pregnancies, and therefore functional cell-based assays can be utilized to measure differences and dissect molecular regulatory pathways.
AB - Functional cell-based assays are useful for comparing the effect of a treatment, drug, or condition on cells in culture. Cell lines are a commonly used model to replicate a normal biological process or a pathological condition. Trophoblasts within the placenta are required to perform a variety of functions, which include proliferation, differentiation, migration, and invasion for efficient placentation to occur. These functions are impaired in trophoblasts from preeclamptic pregnancies, and therefore functional cell-based assays can be utilized to measure differences and dissect molecular regulatory pathways.
UR - http://www.scopus.com/inward/record.url?scp=85037028293&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-7498-6_18
DO - 10.1007/978-1-4939-7498-6_18
M3 - Chapter
SN - 978-1-4939-7497-9
T3 - Methods in Molecular Biology
SP - 233
EP - 246
BT - Preeclampsia. Methods and Protocols
A2 - Murthi, Padma
A2 - Vaillancourt, Cathy
PB - Springer Science + Business Media
ER -