Analyzing Trophoblast Function Using Cell-Based Assays

Katie L Powell, Anthony W Ashton

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

2 Citations (Scopus)

Abstract

Functional cell-based assays are useful for comparing the effect of a treatment, drug, or condition on cells in culture. Cell lines are a commonly used model to replicate a normal biological process or a pathological condition. Trophoblasts within the placenta are required to perform a variety of functions, which include proliferation, differentiation, migration, and invasion for efficient placentation to occur. These functions are impaired in trophoblasts from preeclamptic pregnancies, and therefore functional cell-based assays can be utilized to measure differences and dissect molecular regulatory pathways.

Original languageEnglish
Title of host publicationPreeclampsia. Methods and Protocols
EditorsPadma Murthi, Cathy Vaillancourt
PublisherSpringer Science + Business Media
Pages233-246
Number of pages14
ISBN (Electronic)978-1-4939-7498-6
ISBN (Print)978-1-4939-7497-9
DOIs
Publication statusPublished - 2018
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1710
ISSN (Print)1064-3745

Fingerprint Dive into the research topics of 'Analyzing Trophoblast Function Using Cell-Based Assays'. Together they form a unique fingerprint.

Cite this