Abstract
Functional cell-based assays are useful for comparing the effect of a treatment, drug, or condition on cells in culture. Cell lines are a commonly used model to replicate a normal biological process or a pathological condition. Trophoblasts within the placenta are required to perform a variety of functions, which include proliferation, differentiation, migration, and invasion for efficient placentation to occur. These functions are impaired in trophoblasts from preeclamptic pregnancies, and therefore functional cell-based assays can be utilized to measure differences and dissect molecular regulatory pathways.
| Original language | English |
|---|---|
| Title of host publication | Preeclampsia. Methods and Protocols |
| Editors | Padma Murthi, Cathy Vaillancourt |
| Publisher | Springer Science + Business Media |
| Pages | 233-246 |
| Number of pages | 14 |
| ISBN (Electronic) | 978-1-4939-7498-6 |
| ISBN (Print) | 978-1-4939-7497-9 |
| DOIs | |
| Publication status | Published - 2018 |
| Externally published | Yes |
Publication series
| Name | Methods in Molecular Biology |
|---|---|
| Volume | 1710 |
| ISSN (Print) | 1064-3745 |
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Cite this
Powell, K. L., & Ashton, A. W. (2018). Analyzing Trophoblast Function Using Cell-Based Assays. In P. Murthi, & C. Vaillancourt (Eds.), Preeclampsia. Methods and Protocols (pp. 233-246). (Methods in Molecular Biology; Vol. 1710). Springer Science + Business Media. https://doi.org/10.1007/978-1-4939-7498-6_18