AMPK and Exercise: Glucose Uptake and Insulin Sensitivity: Glucose Uptake and Insulin Sensitivity

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Abstract

AMPK is an evolutionary conserved sensor of cellular energy status that is activated during exercise. Pharmacological activation of AMPK promotes glucose uptake, fatty acid oxidation, mitochondrial biogenesis, and insulin sensitivity; processes that are reduced in obesity and contribute to the development of insulin resistance. AMPK deficient mouse models have been used to provide direct genetic evidence either supporting or refuting a role for AMPK in regulating these processes. Exercise promotes glucose uptake by an insulin dependent mechanism involving AMPK. Exercise is important for improving insulin sensitivity; however, it is not known if AMPK is required for these improvements. Understanding how these metabolic processes are regulated is important for the development of new strategies that target obesity-induced insulin resistance. This review will discuss the involvement of AMPK in regulating skeletal muscle metabolism (glucose uptake, glycogen synthesis, and insulin sensitivity).

Original languageEnglish
Pages (from-to)1-21
Number of pages21
JournalDiabetes and Metabolism Journal
Volume37
Issue number1
DOIs
Publication statusPublished - Feb 2013
Externally publishedYes

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AMP-Activated Protein Kinases
Insulin Resistance
Glucose
Obesity
Organelle Biogenesis
Glycogen
Skeletal Muscle
Fatty Acids
Pharmacology
Insulin

Cite this

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abstract = "AMPK is an evolutionary conserved sensor of cellular energy status that is activated during exercise. Pharmacological activation of AMPK promotes glucose uptake, fatty acid oxidation, mitochondrial biogenesis, and insulin sensitivity; processes that are reduced in obesity and contribute to the development of insulin resistance. AMPK deficient mouse models have been used to provide direct genetic evidence either supporting or refuting a role for AMPK in regulating these processes. Exercise promotes glucose uptake by an insulin dependent mechanism involving AMPK. Exercise is important for improving insulin sensitivity; however, it is not known if AMPK is required for these improvements. Understanding how these metabolic processes are regulated is important for the development of new strategies that target obesity-induced insulin resistance. This review will discuss the involvement of AMPK in regulating skeletal muscle metabolism (glucose uptake, glycogen synthesis, and insulin sensitivity).",
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AMPK and Exercise: Glucose Uptake and Insulin Sensitivity : Glucose Uptake and Insulin Sensitivity. / O'Neill, Hayley M.

In: Diabetes and Metabolism Journal, Vol. 37, No. 1, 02.2013, p. 1-21.

Research output: Contribution to journalArticleResearchpeer-review

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