Amiodarone, adrenoceptor responsiveness and iscaaemia- and reperfusion-induced arrhythmias

Susan J. Coker, Russell Chess-Williams

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Experiments were performed in rats which had been pretreated with amiodarone 50 mg kg-1 day-1 p.o. for 4 weeks. In anaesthetized animals subject to 25 min of coronary artery occlusion, the rats which had received amiodarone had fewer ischaemia-induced ventricular premature beats than the controls (381 ± 106 compared with 815 ± 215, P = 0.070). The duration of arrhythmias induced by reperfusion following 5 min of ischaemia was also less in the rats which had received amiodarone than in the controls (43.8 ± 6.8 and 16.0 ± 3.1 s respectively). Pretreatment of rats with amiodarone reduced the maximum driving frequency of both isolated left atria and papillary muscles. There were no differences between the responses to α- or β-adrenoceptor agonists or to calcium in papillary muscle preparations from amiodarone-pretrcated and control rats. These results suggest that the antiarrhythmic activity of chronic amiodarone seen in the present study does not depend on changes in ventricular adrenoceptor responsiveness.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalEuropean Journal of Pharmacology
Volume201
Issue number1
DOIs
Publication statusPublished - 16 Aug 1991
Externally publishedYes

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Amiodarone
Adrenergic Receptors
Reperfusion
Cardiac Arrhythmias
Papillary Muscles
Ischemia
Ventricular Premature Complexes
Coronary Occlusion
Heart Atria
Coronary Vessels
Calcium

Cite this

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title = "Amiodarone, adrenoceptor responsiveness and iscaaemia- and reperfusion-induced arrhythmias",
abstract = "Experiments were performed in rats which had been pretreated with amiodarone 50 mg kg-1 day-1 p.o. for 4 weeks. In anaesthetized animals subject to 25 min of coronary artery occlusion, the rats which had received amiodarone had fewer ischaemia-induced ventricular premature beats than the controls (381 ± 106 compared with 815 ± 215, P = 0.070). The duration of arrhythmias induced by reperfusion following 5 min of ischaemia was also less in the rats which had received amiodarone than in the controls (43.8 ± 6.8 and 16.0 ± 3.1 s respectively). Pretreatment of rats with amiodarone reduced the maximum driving frequency of both isolated left atria and papillary muscles. There were no differences between the responses to α- or β-adrenoceptor agonists or to calcium in papillary muscle preparations from amiodarone-pretrcated and control rats. These results suggest that the antiarrhythmic activity of chronic amiodarone seen in the present study does not depend on changes in ventricular adrenoceptor responsiveness.",
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Amiodarone, adrenoceptor responsiveness and iscaaemia- and reperfusion-induced arrhythmias. / Coker, Susan J.; Chess-Williams, Russell.

In: European Journal of Pharmacology, Vol. 201, No. 1, 16.08.1991, p. 103-109.

Research output: Contribution to journalArticleResearchpeer-review

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N2 - Experiments were performed in rats which had been pretreated with amiodarone 50 mg kg-1 day-1 p.o. for 4 weeks. In anaesthetized animals subject to 25 min of coronary artery occlusion, the rats which had received amiodarone had fewer ischaemia-induced ventricular premature beats than the controls (381 ± 106 compared with 815 ± 215, P = 0.070). The duration of arrhythmias induced by reperfusion following 5 min of ischaemia was also less in the rats which had received amiodarone than in the controls (43.8 ± 6.8 and 16.0 ± 3.1 s respectively). Pretreatment of rats with amiodarone reduced the maximum driving frequency of both isolated left atria and papillary muscles. There were no differences between the responses to α- or β-adrenoceptor agonists or to calcium in papillary muscle preparations from amiodarone-pretrcated and control rats. These results suggest that the antiarrhythmic activity of chronic amiodarone seen in the present study does not depend on changes in ventricular adrenoceptor responsiveness.

AB - Experiments were performed in rats which had been pretreated with amiodarone 50 mg kg-1 day-1 p.o. for 4 weeks. In anaesthetized animals subject to 25 min of coronary artery occlusion, the rats which had received amiodarone had fewer ischaemia-induced ventricular premature beats than the controls (381 ± 106 compared with 815 ± 215, P = 0.070). The duration of arrhythmias induced by reperfusion following 5 min of ischaemia was also less in the rats which had received amiodarone than in the controls (43.8 ± 6.8 and 16.0 ± 3.1 s respectively). Pretreatment of rats with amiodarone reduced the maximum driving frequency of both isolated left atria and papillary muscles. There were no differences between the responses to α- or β-adrenoceptor agonists or to calcium in papillary muscle preparations from amiodarone-pretrcated and control rats. These results suggest that the antiarrhythmic activity of chronic amiodarone seen in the present study does not depend on changes in ventricular adrenoceptor responsiveness.

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