Amino Acid Kinetics and the Response to Nutrition in Patients with Cancer

Barbara S van der Meij, Laisa Teleni, Marielle Pkj Engelen, Nicolaas Ep Deutz

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Abstract

PURPOSE: Amino acids are involved in many physiological processes in the body and serve as building blocks of proteins which are the main component of muscle mass. Often patients with cancer experience muscle wasting, which is associated with poor outcomes. The purpose of this paper is to discuss amino acid kinetics in cancer, review the evidence on the response to nutrition in patients with cancer, and to give recommendations on the appropriate level of amino acid or protein intake in cancer. Current evidence shows that amino acid kinetics in patients with cancer are disturbed, as reflected by increased and decreased levels of plasma amino acids, an increased whole body turnover of protein and muscle protein breakdown. A few studies show beneficial effects of acute and short-term supplementation of high protein meals or essential amino acid mixtures on muscle protein synthesis.

CONCLUSION: Cancer is associated with disturbances in amino acid kinetics. A high protein intake or supplementation of amino acids may improve muscle protein synthesis. Future research needs to identify the optimal level and amino acid mixtures for patients with cancer, in particular for those who are malnourished.

Original languageEnglish
Pages (from-to)480-492
Number of pages13
JournalInternational Journal of Radiation Biology
Volume95
Issue number4
Early online date3 May 2018
DOIs
Publication statusPublished - 1 Apr 2019

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Amino Acids
Muscle Proteins
Neoplasms
Proteins
Muscle Neoplasms
Physiological Phenomena
Essential Amino Acids
Meals
Muscles

Cite this

van der Meij, Barbara S ; Teleni, Laisa ; Engelen, Marielle Pkj ; Deutz, Nicolaas Ep. / Amino Acid Kinetics and the Response to Nutrition in Patients with Cancer. In: International Journal of Radiation Biology. 2019 ; Vol. 95, No. 4. pp. 480-492.
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Amino Acid Kinetics and the Response to Nutrition in Patients with Cancer. / van der Meij, Barbara S; Teleni, Laisa; Engelen, Marielle Pkj; Deutz, Nicolaas Ep.

In: International Journal of Radiation Biology, Vol. 95, No. 4, 01.04.2019, p. 480-492.

Research output: Contribution to journalArticleResearchpeer-review

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AB - PURPOSE: Amino acids are involved in many physiological processes in the body and serve as building blocks of proteins which are the main component of muscle mass. Often patients with cancer experience muscle wasting, which is associated with poor outcomes. The purpose of this paper is to discuss amino acid kinetics in cancer, review the evidence on the response to nutrition in patients with cancer, and to give recommendations on the appropriate level of amino acid or protein intake in cancer. Current evidence shows that amino acid kinetics in patients with cancer are disturbed, as reflected by increased and decreased levels of plasma amino acids, an increased whole body turnover of protein and muscle protein breakdown. A few studies show beneficial effects of acute and short-term supplementation of high protein meals or essential amino acid mixtures on muscle protein synthesis.CONCLUSION: Cancer is associated with disturbances in amino acid kinetics. A high protein intake or supplementation of amino acids may improve muscle protein synthesis. Future research needs to identify the optimal level and amino acid mixtures for patients with cancer, in particular for those who are malnourished.

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