Aggressive non-melanoma skin cancer

Dimitrios Nikolarakos, Alexander M. Bobinskas, James E. Jackson, Sandeep Bhuta, Marco Matos

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review


Nonmelanoma skin cancer (NMSC) is the most common
malignancy worldwide. NMSC represents a diverse
group of tumors including cutaneous squamous cell
carcinoma (cSCC), basal cell carcinoma (BCC), Merkel cell carcinoma (MCC), dermatofibrosarcoma protuberans, sebaceous
carcinoma, malignant fibrous histiocytoma, and any other cancer of the skin excluding melanoma. Although NMSC includes
numerous pathologies, the term non-melanoma skin cancer is
frequently used to describe BCC and cSCC. To avoid ambiguity, it has been suggested that when jointly referring to only
cSCC and BCC the term keratinocyte carcinoma (KC) should be
used because this does not encompass the other pathologies that
may technically fall under the term non-melanoma skin cancer.
KC is the most common malignancy in the United States; estimates have indicated that 3.5 million cases of KC managed in
2006, with this figure increasing to 5.4 million cases in 2012.
BCC is considered to be more common than cSCC, with cSCC
accounting for approximately 20–30% of KC. The incidence
of cSCC and BCC varies throughout the world. In the United
States the incidence of BCC varies substantially; incidences of
170–936 per 100,000 person-years have been reported, with
higher incidences reported at lower latitudes. The incidence
of BCC in England is estimated to be 76 per 100,000 personyears,6 and Australia has the highest incidence of BCC in the world with more than 1000 per 100,000 person-years reported.
Original languageEnglish
Title of host publicationOral, Head and Neck Oncology and Reconstructive Surgery
EditorsR. Bryan Bell, Rui P. Fernandes, Peter E. Andersen
Number of pages19
ISBN (Electronic)9780323265683
Publication statusPublished - 1 Jan 2017
Externally publishedYes


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