Age, muscle fatigue, and walking endurance in pre-menopausal women

Gary R. Hunter, C. Scott Bickel, Pedro Del Corral, Nuala M. Byrne, Andrew P. Hills, D. Enette Larson-Meyer, Marcas M. Bamman, Bradley R. Newcomer

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Abstract

Aging is associated with loss of endurance; however, aging is also associated with decreased fatigue during maximal isometric contractions. The aims of this study were to examine the relationship between age and walking endurance (WE) and maximal isometric fatigue (MIF) and to determine which metabolic/fitness components explain the expected age effects on WE and MIF. Subjects were 96 pre-menopausal women. Oxygen uptake (walking economy) was assessed during a 3-mph walk; aerobic capacity and WE by progressive treadmill test; knee extension strength by isometric contractions, MIF during a 90-s isometric plantar flexion (muscle metabolism measured by 31P MRS). Age was related to increased walking economy (low VO2, r = -0.19, P < 0.03) and muscle metabolic economy (force/ATP, 0.34, P = 0.01), and reduced MIF (-0.26, P < 0.03). However, age was associated with reduced WE (-0.28, P < 0.01). Multiple regression showed that muscle metabolic economy explained the age-related decrease in MIF (partial r for MIF and age -0.13, P = 0.35) whereas walking economy did not explain the age-related decrease in WE (partial r for WE and age -0.25, P < 0.02). Inclusion of VO2max and knee endurance strength accounted for the age-related decreased WE (partial r for WE and age = 0.03, P > 0.80). In premenopausal women, age is related to WE and MIF. In addition, these results support the hypothesis that age-related increases in metabolic economy may decrease MIF. However, decreased muscle strength and oxidative capacity are related to WE.

Original languageEnglish
Pages (from-to)715-723
Number of pages9
JournalEuropean Journal of Applied Physiology
Volume111
Issue number4
DOIs
Publication statusPublished - Apr 2011
Externally publishedYes

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Muscle Fatigue
Walking
Fatigue
Isometric Contraction
Muscle Strength
Exercise Test
Knee
Oxygen
Muscles

Cite this

Hunter, G. R., Bickel, C. S., Corral, P. D., Byrne, N. M., Hills, A. P., Larson-Meyer, D. E., ... Newcomer, B. R. (2011). Age, muscle fatigue, and walking endurance in pre-menopausal women. European Journal of Applied Physiology, 111(4), 715-723. https://doi.org/10.1007/s00421-010-1694-1
Hunter, Gary R. ; Bickel, C. Scott ; Corral, Pedro Del ; Byrne, Nuala M. ; Hills, Andrew P. ; Larson-Meyer, D. Enette ; Bamman, Marcas M. ; Newcomer, Bradley R. / Age, muscle fatigue, and walking endurance in pre-menopausal women. In: European Journal of Applied Physiology. 2011 ; Vol. 111, No. 4. pp. 715-723.
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Hunter, GR, Bickel, CS, Corral, PD, Byrne, NM, Hills, AP, Larson-Meyer, DE, Bamman, MM & Newcomer, BR 2011, 'Age, muscle fatigue, and walking endurance in pre-menopausal women' European Journal of Applied Physiology, vol. 111, no. 4, pp. 715-723. https://doi.org/10.1007/s00421-010-1694-1

Age, muscle fatigue, and walking endurance in pre-menopausal women. / Hunter, Gary R.; Bickel, C. Scott; Corral, Pedro Del; Byrne, Nuala M.; Hills, Andrew P.; Larson-Meyer, D. Enette; Bamman, Marcas M.; Newcomer, Bradley R.

In: European Journal of Applied Physiology, Vol. 111, No. 4, 04.2011, p. 715-723.

Research output: Contribution to journalArticleResearchpeer-review

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Hunter GR, Bickel CS, Corral PD, Byrne NM, Hills AP, Larson-Meyer DE et al. Age, muscle fatigue, and walking endurance in pre-menopausal women. European Journal of Applied Physiology. 2011 Apr;111(4):715-723. https://doi.org/10.1007/s00421-010-1694-1