Adenosine role in brain functions: Pathophysiological influence on Parkinson's disease and other brain disorders

Amira M. Soliman; Ahmed M. Fathalla; Ahmed A. Moustafa

doi:10.1016/j.pharep.2018.02.003

Adenosine role in brain functions: Pathophysiological influence on Parkinson's disease and other brain disorders

Amira M. Soliman^*
, Ahmed M. Fathalla
, Ahmed A. Moustafa

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Research › peer-review

24 Citations (Scopus)

Abstract

Although adenosine plays a key role in multiple motor, affective, and cognitive processes, it has received less attention in the neuroscience field compared to other neurotransmitters (e.g., dopamine). In this review, we highlight the role of adenosine in behavior as well as its interaction with other neurotransmitters, such as dopamine. We also discuss brain disorders impacted by alterations to adenosine, and how targeting adenosine can ameliorate Parkinson's disease motor symptoms. We also discuss the role of caffeine (as an adenosine antagonist) on cognition as well as a neuroprotective agent against Parkinson's disease (PD).

Original language	English
Pages (from-to)	661-667
Number of pages	7
Journal	Pharmacological Reports
Volume	70
Issue number	4
DOIs	https://doi.org/10.1016/j.pharep.2018.02.003
Publication status	Published - Aug 2018
Externally published	Yes

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10.1016/j.pharep.2018.02.003

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title = "Adenosine role in brain functions: Pathophysiological influence on Parkinson's disease and other brain disorders",

abstract = "Although adenosine plays a key role in multiple motor, affective, and cognitive processes, it has received less attention in the neuroscience field compared to other neurotransmitters (e.g., dopamine). In this review, we highlight the role of adenosine in behavior as well as its interaction with other neurotransmitters, such as dopamine. We also discuss brain disorders impacted by alterations to adenosine, and how targeting adenosine can ameliorate Parkinson's disease motor symptoms. We also discuss the role of caffeine (as an adenosine antagonist) on cognition as well as a neuroprotective agent against Parkinson's disease (PD).",

author = "Soliman, \{Amira M.\} and Fathalla, \{Ahmed M.\} and Moustafa, \{Ahmed A.\}",

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language = "English",

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AU - Soliman, Amira M.

AU - Fathalla, Ahmed M.

AU - Moustafa, Ahmed A.

PY - 2018/8

Y1 - 2018/8

N2 - Although adenosine plays a key role in multiple motor, affective, and cognitive processes, it has received less attention in the neuroscience field compared to other neurotransmitters (e.g., dopamine). In this review, we highlight the role of adenosine in behavior as well as its interaction with other neurotransmitters, such as dopamine. We also discuss brain disorders impacted by alterations to adenosine, and how targeting adenosine can ameliorate Parkinson's disease motor symptoms. We also discuss the role of caffeine (as an adenosine antagonist) on cognition as well as a neuroprotective agent against Parkinson's disease (PD).

AB - Although adenosine plays a key role in multiple motor, affective, and cognitive processes, it has received less attention in the neuroscience field compared to other neurotransmitters (e.g., dopamine). In this review, we highlight the role of adenosine in behavior as well as its interaction with other neurotransmitters, such as dopamine. We also discuss brain disorders impacted by alterations to adenosine, and how targeting adenosine can ameliorate Parkinson's disease motor symptoms. We also discuss the role of caffeine (as an adenosine antagonist) on cognition as well as a neuroprotective agent against Parkinson's disease (PD).

UR - https://www.scopus.com/pages/publications/85048390808

U2 - 10.1016/j.pharep.2018.02.003

DO - 10.1016/j.pharep.2018.02.003

M3 - Review article

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AN - SCOPUS:85048390808

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JO - Pharmacological Reports

JF - Pharmacological Reports

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ER -

Adenosine role in brain functions: Pathophysiological influence on Parkinson's disease and other brain disorders

Abstract

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Corrigendum to “Adenosine role in brain functions: Pathophysiological influence on Parkinson’s disease and other brain disorders” [Pharmacol. Rep. 70 (2018) 661–667]

Cite this

Adenosine role in brain functions: Pathophysiological influence on Parkinson's disease and other brain disorders

Abstract

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Fingerprint

Related Research Outputs

Corrigendum to “Adenosine role in brain functions: Pathophysiological influence on Parkinson’s disease and other brain disorders” [Pharmacol. Rep. 70 (2018) 661–667]

Cite this