Adenosine role in brain functions: Pathophysiological influence on Parkinson's disease and other brain disorders

Amira M. Soliman*, Ahmed M. Fathalla, Ahmed A. Moustafa

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

18 Citations (Scopus)

Abstract

Although adenosine plays a key role in multiple motor, affective, and cognitive processes, it has received less attention in the neuroscience field compared to other neurotransmitters (e.g., dopamine). In this review, we highlight the role of adenosine in behavior as well as its interaction with other neurotransmitters, such as dopamine. We also discuss brain disorders impacted by alterations to adenosine, and how targeting adenosine can ameliorate Parkinson's disease motor symptoms. We also discuss the role of caffeine (as an adenosine antagonist) on cognition as well as a neuroprotective agent against Parkinson's disease (PD).

Original languageEnglish
Pages (from-to)661-667
Number of pages7
JournalPharmacological Reports
Volume70
Issue number4
DOIs
Publication statusPublished - Aug 2018
Externally publishedYes

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