TY - JOUR
T1 - Acute effects of whey protein, alone and mixed with other macronutrients, on blood pressure and heart rate in older men
AU - Oberoi, Avneet
AU - Giezenaar, Caroline
AU - Lange, Kylie
AU - Jones, Karen L.
AU - Horowitz, Michael
AU - Chapman, Ian
AU - Soenen, Stijn
N1 - Funding Information:
The research was funded by a Royal Adelaide Hospital Clinical Project Grant (#1753). Stijn Soenen was supported by a Royal Adelaide Hospital Florey Fellowship (#2129).
Funding Information:
We thank Fonterra Research and Development Centre, Palmerston North, New Zealand, for providing the whey protein (isolated whey protein, description #104641), and Rachael Rigda and Seva Hatzinikolas, Centre of Research Excellence in Translating Nutritional Research to Good Health, Discipline of Medicine, Royal Adelaide Hospital, the University of Adelaide for assistance during the study days. Karen Jones’ salary was supported by a University of Adelaide William T Sothcott Research Fellowship.
Funding Information:
We thank Fonterra Research and Development Centre, Palmerston North, New Zealand, for providing the whey protein (isolated whey protein, description #104641), and Rachael Rigda and Seva Hatzinikolas, Centre of Research Excellence in Translating Nutritional Research to Good Health, Discipline of Medicine, Royal Adelaide Hospital, the University of Adelaide for assistance during the study days. Karen Jones’ salary was supported by a University of Adelaide William T Sothcott Research Fellowship.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/6/28
Y1 - 2022/6/28
N2 - BACKGROUND: Caloric supplements are increasingly used by older people, aiming to increase their daily protein intake. These high caloric drinks, rich in glucose and whey-protein in particular, may result in potential harmful decreases in blood pressure (BP). The effect of ingesting whey-protein with glucose and fat on BP is unknown. It has also been assumed that the maximum fall in systolic blood pressure occurs within 2 h of a meal.METHODS: This study aimed to determine in older men, the effects of whey-protein, alone and mixed with other macronutrients, on systolic (SBP) and diastolic (DBP) blood pressure and heart rate (HR) in older men for 3 h. Thirteen older men (age 75 ± 2yrs; body mass index (BMI) 25.6 ± 0.6 kg/m
2) ingested a drink on separate study days: (i) 70 g whey-protein (P
280)
; (ii) 14 g whey-protein, 28 g carbohydrate, 12.4 g fat (M
280); (iii) 70 g whey-protein, 28 g carbohydrate, 12.4 g fat (M
504); or (iv) a non-caloric control drink (C).
RESULTS: SBP decreased after all three nutrient drinks compared to the C, with the greatest reduction after the M
504 drink (P = 0.008). Maximal decreases in SBP (C: -14 ± 2 mmHg, P
280: -22 ± 2 mmHg, M
280: -22 ± 4 mmHg, M
504: -24 ± 3 mmHg) occurred about 2 h after drink ingestion and this fall was sustained thereafter (120-180 min: P
280 and M
504 vs. C P < 0.05). Maximum DBP decreases and HR increases occurred after M
504, with no differences between the effects of the P
280 and M
280 drinks.
CONCLUSIONS: The effects of whey-protein containing drinks to lower BP and increase HR appear to be primarily dependent on their energy content rather than macronutrient composition and may persist for at least 3 h after ingestion,. Pure whey-protein drinks may represent the best approach to maximize protein intake without increasing the potential for deleterious BP falls in older people.TRIAL REGISTRATION: ACTRN12614000846628 , 14/03/2019.
AB - BACKGROUND: Caloric supplements are increasingly used by older people, aiming to increase their daily protein intake. These high caloric drinks, rich in glucose and whey-protein in particular, may result in potential harmful decreases in blood pressure (BP). The effect of ingesting whey-protein with glucose and fat on BP is unknown. It has also been assumed that the maximum fall in systolic blood pressure occurs within 2 h of a meal.METHODS: This study aimed to determine in older men, the effects of whey-protein, alone and mixed with other macronutrients, on systolic (SBP) and diastolic (DBP) blood pressure and heart rate (HR) in older men for 3 h. Thirteen older men (age 75 ± 2yrs; body mass index (BMI) 25.6 ± 0.6 kg/m
2) ingested a drink on separate study days: (i) 70 g whey-protein (P
280)
; (ii) 14 g whey-protein, 28 g carbohydrate, 12.4 g fat (M
280); (iii) 70 g whey-protein, 28 g carbohydrate, 12.4 g fat (M
504); or (iv) a non-caloric control drink (C).
RESULTS: SBP decreased after all three nutrient drinks compared to the C, with the greatest reduction after the M
504 drink (P = 0.008). Maximal decreases in SBP (C: -14 ± 2 mmHg, P
280: -22 ± 2 mmHg, M
280: -22 ± 4 mmHg, M
504: -24 ± 3 mmHg) occurred about 2 h after drink ingestion and this fall was sustained thereafter (120-180 min: P
280 and M
504 vs. C P < 0.05). Maximum DBP decreases and HR increases occurred after M
504, with no differences between the effects of the P
280 and M
280 drinks.
CONCLUSIONS: The effects of whey-protein containing drinks to lower BP and increase HR appear to be primarily dependent on their energy content rather than macronutrient composition and may persist for at least 3 h after ingestion,. Pure whey-protein drinks may represent the best approach to maximize protein intake without increasing the potential for deleterious BP falls in older people.TRIAL REGISTRATION: ACTRN12614000846628 , 14/03/2019.
UR - http://www.scopus.com/inward/record.url?scp=85133032487&partnerID=8YFLogxK
U2 - 10.1186/s12877-022-03213-1
DO - 10.1186/s12877-022-03213-1
M3 - Article
C2 - 35764960
AN - SCOPUS:85133032487
SN - 1471-2318
VL - 22
JO - BMC Geriatrics
JF - BMC Geriatrics
IS - 1
M1 - 535
ER -