[Extract] We read with interest the paper by Duncan et al. (2013), who used intracranial EEG (icEEG) to investigate the electrophysiological underpinnings of the default mode network (DMN). Using various functional connectivity (FC) measures, the authors estimated the coupling between electrodes located in two areas of the DMN (i.e., mesial frontal and anterior cingulate cortices; posterior cingulate cortex (PCC) and precuneus) and compared it with electrodes placed outside the DMN. Interestingly, FC was not significantly higher within the DMN than between DMN and non-DMN electrodes. This finding was interpreted as a lack of electrophysiological relationship within the DMN that may have various explanations, the most audacious being that the DMN has no neural foundation.
Wens, V., Mary, A., Bourguignon, M., Goldman, S., Marty, B., beeck, M. O. D., Bogaert, P. V., Peigneux, P., & Tiège, X. D. (2014). About the electrophysiological basis of resting state networks. Clinical Neurophysiology, 125(8), 1711-1713. https://doi.org/10.1016/j.clinph.2013.11.039