A1C to detect diabetes in healthy adults: When should we recheck?

Osamu Takahashi, Andrew J. Farmer, Takuro Shimbo, Tsuguya Fukui, Paul P. Glasziou

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

OBJECTIVE - To evaluate the optimal interval for rechecking A1C levels below the diagnostic threshold of 6.5% for healthy adults. RESEARCH DESIGN AND METHODS - This was a retrospective cohort study. Participants were 16,313 apparently healthy Japanese adults not taking glucose-lowering medications at baseline. Annual A1C measures from 2005 to 2008 at the Center for Preventive Medicine, a community teaching hospital in Japan, estimated cumulative incidence of diabetes. RESULTS - Mean age (±SD) of participants was 49.7 ± 12.3 years, and 53% were male. Mean A1C at baseline was 5.4 ± 0.5%. At 3 years, for those with A1C at baseline of <5.0%, 5.0 -5.4%, 5.5-5.9%, and 6.0-6.4%, cumulative incidence (95% CI) was 0.05% (0.001-0.3), 0.05% (0.01-0.11), 1.2% (0.9-1.6), and 20% (18-23), respectively. CONCLUSIONS - In those with an A1C <6.0%, rescreening at intervals shorter than 3 years identifies few individuals (∼≤1%) with an A1C ≥6.5%.

Original languageEnglish
Pages (from-to)2016-2017
Number of pages2
JournalDiabetes Care
Volume33
Issue number9
DOIs
Publication statusPublished - Sep 2010

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Preventive Medicine
Incidence
Community Hospital
Teaching Hospitals
Japan
Cohort Studies
Research Design
Retrospective Studies
Glucose

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Takahashi, Osamu ; Farmer, Andrew J. ; Shimbo, Takuro ; Fukui, Tsuguya ; Glasziou, Paul P. / A1C to detect diabetes in healthy adults : When should we recheck?. In: Diabetes Care. 2010 ; Vol. 33, No. 9. pp. 2016-2017.
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title = "A1C to detect diabetes in healthy adults: When should we recheck?",
abstract = "OBJECTIVE - To evaluate the optimal interval for rechecking A1C levels below the diagnostic threshold of 6.5{\%} for healthy adults. RESEARCH DESIGN AND METHODS - This was a retrospective cohort study. Participants were 16,313 apparently healthy Japanese adults not taking glucose-lowering medications at baseline. Annual A1C measures from 2005 to 2008 at the Center for Preventive Medicine, a community teaching hospital in Japan, estimated cumulative incidence of diabetes. RESULTS - Mean age (±SD) of participants was 49.7 ± 12.3 years, and 53{\%} were male. Mean A1C at baseline was 5.4 ± 0.5{\%}. At 3 years, for those with A1C at baseline of <5.0{\%}, 5.0 -5.4{\%}, 5.5-5.9{\%}, and 6.0-6.4{\%}, cumulative incidence (95{\%} CI) was 0.05{\%} (0.001-0.3), 0.05{\%} (0.01-0.11), 1.2{\%} (0.9-1.6), and 20{\%} (18-23), respectively. CONCLUSIONS - In those with an A1C <6.0{\%}, rescreening at intervals shorter than 3 years identifies few individuals (∼≤1{\%}) with an A1C ≥6.5{\%}.",
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Takahashi, O, Farmer, AJ, Shimbo, T, Fukui, T & Glasziou, PP 2010, 'A1C to detect diabetes in healthy adults: When should we recheck?' Diabetes Care, vol. 33, no. 9, pp. 2016-2017. https://doi.org/10.2337/dc10-0588

A1C to detect diabetes in healthy adults : When should we recheck? / Takahashi, Osamu; Farmer, Andrew J.; Shimbo, Takuro; Fukui, Tsuguya; Glasziou, Paul P.

In: Diabetes Care, Vol. 33, No. 9, 09.2010, p. 2016-2017.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Takahashi, Osamu

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AU - Glasziou, Paul P.

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N2 - OBJECTIVE - To evaluate the optimal interval for rechecking A1C levels below the diagnostic threshold of 6.5% for healthy adults. RESEARCH DESIGN AND METHODS - This was a retrospective cohort study. Participants were 16,313 apparently healthy Japanese adults not taking glucose-lowering medications at baseline. Annual A1C measures from 2005 to 2008 at the Center for Preventive Medicine, a community teaching hospital in Japan, estimated cumulative incidence of diabetes. RESULTS - Mean age (±SD) of participants was 49.7 ± 12.3 years, and 53% were male. Mean A1C at baseline was 5.4 ± 0.5%. At 3 years, for those with A1C at baseline of <5.0%, 5.0 -5.4%, 5.5-5.9%, and 6.0-6.4%, cumulative incidence (95% CI) was 0.05% (0.001-0.3), 0.05% (0.01-0.11), 1.2% (0.9-1.6), and 20% (18-23), respectively. CONCLUSIONS - In those with an A1C <6.0%, rescreening at intervals shorter than 3 years identifies few individuals (∼≤1%) with an A1C ≥6.5%.

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