A Visual Organic Chemistry Reaction: The Synthesis of 4-Amino-3-nitrobenzoic Acid Methyl Ester via Fischer Esterification

Caleb Kam, Stephan M Levonis, Stephanie S Schweiker*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

The synthesis of 4-amino-3-nitrobenzoic acid methyl ester is a simple Fischer esterification reaction designed as an experiment for use in an introductory organic chemistry course. The compound was synthesized as a one-pot reaction within 30 min to 16 h, with 1 h producing a workable yield. The bright-yellow solid was purified using liquid–liquid extraction, and the extraction process was monitored by a marked color change. The product was then characterized by 1H and 13C NMR spectroscopy and thin-layer chromatography.
Original languageEnglish
Pages (from-to)1997-2000
Number of pages4
JournalJournal of Chemical Education
Volume97
Issue number7
Early online date23 Jun 2020
DOIs
Publication statusPublished - 14 Jul 2020

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