TY - JOUR
T1 - A Visual Organic Chemistry Reaction: The Synthesis of 4-Amino-3-nitrobenzoic Acid Methyl Ester via Fischer Esterification
AU - Kam, Caleb
AU - Levonis, Stephan M
AU - Schweiker, Stephanie S
PY - 2020/7/14
Y1 - 2020/7/14
N2 - The synthesis of 4-amino-3-nitrobenzoic acid methyl ester is a simple Fischer esterification reaction designed as an experiment for use in an introductory organic chemistry course. The compound was synthesized as a one-pot reaction within 30 min to 16 h, with 1 h producing a workable yield. The bright-yellow solid was purified using liquid–liquid extraction, and the extraction process was monitored by a marked color change. The product was then characterized by 1H and 13C NMR spectroscopy and thin-layer chromatography.
AB - The synthesis of 4-amino-3-nitrobenzoic acid methyl ester is a simple Fischer esterification reaction designed as an experiment for use in an introductory organic chemistry course. The compound was synthesized as a one-pot reaction within 30 min to 16 h, with 1 h producing a workable yield. The bright-yellow solid was purified using liquid–liquid extraction, and the extraction process was monitored by a marked color change. The product was then characterized by 1H and 13C NMR spectroscopy and thin-layer chromatography.
UR - http://www.scopus.com/inward/record.url?scp=85087719978&partnerID=8YFLogxK
U2 - 10.1021/acs.jchemed.9b01168
DO - 10.1021/acs.jchemed.9b01168
M3 - Article
SN - 0021-9584
VL - 97
SP - 1997
EP - 2000
JO - Journal of Chemical Education
JF - Journal of Chemical Education
IS - 7
ER -