A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infection

Stuart D. Blacksell; Jenny A. Doust; Paul N. Newton; Sharon J. Peacock; Nicholas P. J. Day; Arjen M. Dondorp

doi:10.1016/j.trstmh.2005.10.018

A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infection

Stuart D. Blacksell, Jenny A. Doust, Paul N. Newton, Sharon J. Peacock, Nicholas P. J. Day^*, Arjen M. Dondorp

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Research › peer-review

41 Citations (Scopus)

Abstract

A meta-analysis of rapid (≤60 min) dengue diagnostic assays was conducted to determine accuracy and identify causes of between-study heterogeneity. A systematic review identified 302 potentially suitable studies, of which 11 were selected for meta-analysis. All selected studies evaluated the immunochromatographic test (ICT) manufactured by Panbio Pty Ltd. Individual study results for sensitivity ranged from 0.45 to 1.0, specificity 0.57–1.0, diagnostic odds ratio 4.5–1287, and positive:negative likelihood ratios 2.3–59 and 0.01–0.56, respectively. Results indicated that the ICT evaluated in the selected studies can both rule in and rule out disease but is more accurate when samples are collected later in the acute phase of infection. Limitations of this meta-analysis were significant between-study heterogeneity caused by inconsistencies in evaluation methodologies, and the evaluation of only the Panbio ICT. It is recommended that additional, standardized evaluations are required for other dengue ICTs.

Original language	English
Pages (from-to)	775-784
Number of pages	10
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	100
Issue number	8
DOIs	https://doi.org/10.1016/j.trstmh.2005.10.018
Publication status	Published - Aug 2006
Externally published	Yes

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Blacksell, S. D., Doust, J. A., Newton, P. N., Peacock, S. J., Day, N. P. J., & Dondorp, A. M. (2006). A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infection. Transactions of the Royal Society of Tropical Medicine and Hygiene, 100(8), 775-784. https://doi.org/10.1016/j.trstmh.2005.10.018

Blacksell, Stuart D. ; Doust, Jenny A. ; Newton, Paul N. ; Peacock, Sharon J. ; Day, Nicholas P. J. ; Dondorp, Arjen M. / A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infection. In: Transactions of the Royal Society of Tropical Medicine and Hygiene. 2006 ; Vol. 100, No. 8. pp. 775-784.

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title = "A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infection",

abstract = "A meta-analysis of rapid (≤60 min) dengue diagnostic assays was conducted to determine accuracy and identify causes of between-study heterogeneity. A systematic review identified 302 potentially suitable studies, of which 11 were selected for meta-analysis. All selected studies evaluated the immunochromatographic test (ICT) manufactured by Panbio Pty Ltd. Individual study results for sensitivity ranged from 0.45 to 1.0, specificity 0.57–1.0, diagnostic odds ratio 4.5–1287, and positive:negative likelihood ratios 2.3–59 and 0.01–0.56, respectively. Results indicated that the ICT evaluated in the selected studies can both rule in and rule out disease but is more accurate when samples are collected later in the acute phase of infection. Limitations of this meta-analysis were significant between-study heterogeneity caused by inconsistencies in evaluation methodologies, and the evaluation of only the Panbio ICT. It is recommended that additional, standardized evaluations are required for other dengue ICTs.",

author = "Blacksell, {Stuart D.} and Doust, {Jenny A.} and Newton, {Paul N.} and Peacock, {Sharon J.} and Day, {Nicholas P. J.} and Dondorp, {Arjen M.}",

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Blacksell, SD, Doust, JA, Newton, PN, Peacock, SJ, Day, NPJ & Dondorp, AM 2006, 'A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infection', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 100, no. 8, pp. 775-784. https://doi.org/10.1016/j.trstmh.2005.10.018

A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infection. / Blacksell, Stuart D.; Doust, Jenny A.; Newton, Paul N.; Peacock, Sharon J.; Day, Nicholas P. J.; Dondorp, Arjen M.

In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 100, No. 8, 08.2006, p. 775-784.

Research output: Contribution to journal › Review article › Research › peer-review

TY - JOUR

T1 - A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infection

AU - Blacksell, Stuart D.

AU - Doust, Jenny A.

AU - Newton, Paul N.

AU - Peacock, Sharon J.

AU - Day, Nicholas P. J.

AU - Dondorp, Arjen M.

PY - 2006/8

Y1 - 2006/8

N2 - A meta-analysis of rapid (≤60 min) dengue diagnostic assays was conducted to determine accuracy and identify causes of between-study heterogeneity. A systematic review identified 302 potentially suitable studies, of which 11 were selected for meta-analysis. All selected studies evaluated the immunochromatographic test (ICT) manufactured by Panbio Pty Ltd. Individual study results for sensitivity ranged from 0.45 to 1.0, specificity 0.57–1.0, diagnostic odds ratio 4.5–1287, and positive:negative likelihood ratios 2.3–59 and 0.01–0.56, respectively. Results indicated that the ICT evaluated in the selected studies can both rule in and rule out disease but is more accurate when samples are collected later in the acute phase of infection. Limitations of this meta-analysis were significant between-study heterogeneity caused by inconsistencies in evaluation methodologies, and the evaluation of only the Panbio ICT. It is recommended that additional, standardized evaluations are required for other dengue ICTs.

AB - A meta-analysis of rapid (≤60 min) dengue diagnostic assays was conducted to determine accuracy and identify causes of between-study heterogeneity. A systematic review identified 302 potentially suitable studies, of which 11 were selected for meta-analysis. All selected studies evaluated the immunochromatographic test (ICT) manufactured by Panbio Pty Ltd. Individual study results for sensitivity ranged from 0.45 to 1.0, specificity 0.57–1.0, diagnostic odds ratio 4.5–1287, and positive:negative likelihood ratios 2.3–59 and 0.01–0.56, respectively. Results indicated that the ICT evaluated in the selected studies can both rule in and rule out disease but is more accurate when samples are collected later in the acute phase of infection. Limitations of this meta-analysis were significant between-study heterogeneity caused by inconsistencies in evaluation methodologies, and the evaluation of only the Panbio ICT. It is recommended that additional, standardized evaluations are required for other dengue ICTs.

U2 - 10.1016/j.trstmh.2005.10.018

DO - 10.1016/j.trstmh.2005.10.018

M3 - Review article

VL - 100

SP - 775

EP - 784

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

SN - 0035-9203

IS - 8

ER -

Blacksell SD, Doust JA, Newton PN, Peacock SJ, Day NPJ, Dondorp AM. A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infection. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2006 Aug;100(8):775-784. https://doi.org/10.1016/j.trstmh.2005.10.018

A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infection

Abstract

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