A Stromal Organiser Cell that Directs Neonatal Spleen Regeneration

Jonathan Kah Huat Tan, Takeshi Watanabe

Research output: Contribution to conferencePresentationResearch

Abstract

Development of lymphoid tissue is determined by interactions
between stromal lymphoid tissue organiser (LTo) and hematopoietic lymphoid tissue inducer (LTi) cells. A failure for LTo to receive appropriate activating signals during embryogenesis through lymphotoxin engagement leads to a complete cessation of lymph node (LN) and Peyer’s patch development, identifying LTo as a key stromal population for lymphoid tissue organogenesis. However, little is known about the equivalent stromal cells that induce spleen development. Here, by dissociating neonatal murine spleen stromal tissue for re-aggregation and transplant into adult mouse recipients, we have identified a MAdCAM- 1+CD31+CD201+ spleen stromal organizer cell-type critical for new tissue formation. This finding provides an insight into the regulation of post-natal spleen tissue organogenesis, and could be exploited in the development of spleen regenerative therapies.
Original languageEnglish
Pages29
Number of pages1
Publication statusPublished - 13 Nov 2016
EventAustralian Society of Medical Research National Scientific Conference - Bond University, Gold Coast, Australia
Duration: 13 Nov 201615 Nov 2016
Conference number: 53rd

Conference

ConferenceAustralian Society of Medical Research National Scientific Conference
CountryAustralia
CityGold Coast
Period13/11/1615/11/16

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Tan, J. K. H., & Watanabe, T. (2016). A Stromal Organiser Cell that Directs Neonatal Spleen Regeneration. 29. Australian Society of Medical Research National Scientific Conference, Gold Coast, Australia.