A role for niches in the development of a multiplicity of dendritic cell subsets

G Despars; HC O'Neill

doi:10.1016/j.exphem.2003.12.004

A role for niches in the development of a multiplicity of dendritic cell subsets

G Despars^*, HC O'Neill

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Research › peer-review

19 Citations (Scopus)

Abstract

Although most studies on murine dendritic cell (DC) differentiation concentrate on the nature of the DC precursor population and the lineage relationship between DC and other hematopoietic cell types, very little research addresses the nature of the microenvironments necessary for DC hematopoiesis. Evidence supporting a major contribution of niches in DC differentiation within hematopoietic tissues is reviewed. A model is presented that identifies a potential role for multiple hematopoietic niches in DC differentiation. It is proposed that multiple DC subsets develop from one or a small number of DC progenitor types that lodge in various niches within different tissue sites. Implications of a niche-mediated model for differentiation of DC precursors are discussed in the context of both physiological and pathological situations. (C) 2004 International Society for Experimental Hematology. Published by Elsevier Inc.

Original language	English
Pages (from-to)	235-243
Number of pages	9
Journal	Experimental Hematology
Volume	32
Issue number	3
DOIs	https://doi.org/10.1016/j.exphem.2003.12.004
Publication status	Published - Mar 2004
Externally published	Yes

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10.1016/j.exphem.2003.12.004

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title = "A role for niches in the development of a multiplicity of dendritic cell subsets",

abstract = "Although most studies on murine dendritic cell (DC) differentiation concentrate on the nature of the DC precursor population and the lineage relationship between DC and other hematopoietic cell types, very little research addresses the nature of the microenvironments necessary for DC hematopoiesis. Evidence supporting a major contribution of niches in DC differentiation within hematopoietic tissues is reviewed. A model is presented that identifies a potential role for multiple hematopoietic niches in DC differentiation. It is proposed that multiple DC subsets develop from one or a small number of DC progenitor types that lodge in various niches within different tissue sites. Implications of a niche-mediated model for differentiation of DC precursors are discussed in the context of both physiological and pathological situations. (C) 2004 International Society for Experimental Hematology. Published by Elsevier Inc.",

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doi = "10.1016/j.exphem.2003.12.004",

language = "English",

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T1 - A role for niches in the development of a multiplicity of dendritic cell subsets

AU - Despars, G

AU - O'Neill, HC

PY - 2004/3

Y1 - 2004/3

N2 - Although most studies on murine dendritic cell (DC) differentiation concentrate on the nature of the DC precursor population and the lineage relationship between DC and other hematopoietic cell types, very little research addresses the nature of the microenvironments necessary for DC hematopoiesis. Evidence supporting a major contribution of niches in DC differentiation within hematopoietic tissues is reviewed. A model is presented that identifies a potential role for multiple hematopoietic niches in DC differentiation. It is proposed that multiple DC subsets develop from one or a small number of DC progenitor types that lodge in various niches within different tissue sites. Implications of a niche-mediated model for differentiation of DC precursors are discussed in the context of both physiological and pathological situations. (C) 2004 International Society for Experimental Hematology. Published by Elsevier Inc.

AB - Although most studies on murine dendritic cell (DC) differentiation concentrate on the nature of the DC precursor population and the lineage relationship between DC and other hematopoietic cell types, very little research addresses the nature of the microenvironments necessary for DC hematopoiesis. Evidence supporting a major contribution of niches in DC differentiation within hematopoietic tissues is reviewed. A model is presented that identifies a potential role for multiple hematopoietic niches in DC differentiation. It is proposed that multiple DC subsets develop from one or a small number of DC progenitor types that lodge in various niches within different tissue sites. Implications of a niche-mediated model for differentiation of DC precursors are discussed in the context of both physiological and pathological situations. (C) 2004 International Society for Experimental Hematology. Published by Elsevier Inc.

U2 - 10.1016/j.exphem.2003.12.004

DO - 10.1016/j.exphem.2003.12.004

M3 - Review article

C2 - 15003308

SN - 0301-472X

VL - 32

SP - 235

EP - 243

JO - Experimental Hematology

JF - Experimental Hematology

IS - 3

ER -

A role for niches in the development of a multiplicity of dendritic cell subsets

Abstract

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