A Review of Black Salve: Cancer Specificity, Cure, and Cosmesis

Andrew Croaker, Graham J. King, John H. Pyne, Shailendra Anoopkumar-Dukie, Lei Liu

Research output: Contribution to journalReview articleResearchpeer-review

3 Citations (Scopus)
19 Downloads (Pure)

Abstract

Black salve is a topical escharotic used for the treatment of skin cancer. Although promoted as a safe and effective alternative to conventional management by its proponents, limited clinical research has been undertaken to assess its efficacy and potential toxicities. Patients are increasingly utilizing the Internet as a source of health information. As a minimally regulated space, the quality and accuracy of this information vary considerably. This review explores four health claims made by black salve vendors, investigating its natural therapy credentials, tumour specificity, and equivalence to orthodox medicine in relation to skin cancer cure rates and cosmesis. Based upon an analysis of in vitro constituent cytotoxicity, in vivo post black salve histology, and experience with Mohs paste, black salve is likely to possess normal tissue toxicity with some cancer cell lines being relatively resistant to its effects. This may explain the incongruous case study reports of excessive scarring, deformity, and treatment failure.

Original languageEnglish
Article number9184034
JournalEvidence-Based Complementary and Alternative Medicine
Volume2017
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

Fingerprint

Ointments
Skin Neoplasms
Neoplasms
Health
Treatment Failure
Internet
Cicatrix
Histology
Medicine
Cell Line
Therapeutics
Research

Cite this

Croaker, Andrew ; King, Graham J. ; Pyne, John H. ; Anoopkumar-Dukie, Shailendra ; Liu, Lei. / A Review of Black Salve : Cancer Specificity, Cure, and Cosmesis. In: Evidence-Based Complementary and Alternative Medicine. 2017 ; Vol. 2017.
@article{f328e3532ef4417b977889cf58e2c739,
title = "A Review of Black Salve: Cancer Specificity, Cure, and Cosmesis",
abstract = "Black salve is a topical escharotic used for the treatment of skin cancer. Although promoted as a safe and effective alternative to conventional management by its proponents, limited clinical research has been undertaken to assess its efficacy and potential toxicities. Patients are increasingly utilizing the Internet as a source of health information. As a minimally regulated space, the quality and accuracy of this information vary considerably. This review explores four health claims made by black salve vendors, investigating its natural therapy credentials, tumour specificity, and equivalence to orthodox medicine in relation to skin cancer cure rates and cosmesis. Based upon an analysis of in vitro constituent cytotoxicity, in vivo post black salve histology, and experience with Mohs paste, black salve is likely to possess normal tissue toxicity with some cancer cell lines being relatively resistant to its effects. This may explain the incongruous case study reports of excessive scarring, deformity, and treatment failure.",
author = "Andrew Croaker and King, {Graham J.} and Pyne, {John H.} and Shailendra Anoopkumar-Dukie and Lei Liu",
year = "2017",
month = "1",
day = "1",
doi = "10.1155/2017/9184034",
language = "English",
volume = "2017",
journal = "Evidence-Based Complementary and Alternative Medicine",
issn = "1741-427X",
publisher = "Hindawi Publishing Corporation",

}

A Review of Black Salve : Cancer Specificity, Cure, and Cosmesis. / Croaker, Andrew; King, Graham J.; Pyne, John H.; Anoopkumar-Dukie, Shailendra; Liu, Lei.

In: Evidence-Based Complementary and Alternative Medicine, Vol. 2017, 9184034, 01.01.2017.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - A Review of Black Salve

T2 - Cancer Specificity, Cure, and Cosmesis

AU - Croaker, Andrew

AU - King, Graham J.

AU - Pyne, John H.

AU - Anoopkumar-Dukie, Shailendra

AU - Liu, Lei

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Black salve is a topical escharotic used for the treatment of skin cancer. Although promoted as a safe and effective alternative to conventional management by its proponents, limited clinical research has been undertaken to assess its efficacy and potential toxicities. Patients are increasingly utilizing the Internet as a source of health information. As a minimally regulated space, the quality and accuracy of this information vary considerably. This review explores four health claims made by black salve vendors, investigating its natural therapy credentials, tumour specificity, and equivalence to orthodox medicine in relation to skin cancer cure rates and cosmesis. Based upon an analysis of in vitro constituent cytotoxicity, in vivo post black salve histology, and experience with Mohs paste, black salve is likely to possess normal tissue toxicity with some cancer cell lines being relatively resistant to its effects. This may explain the incongruous case study reports of excessive scarring, deformity, and treatment failure.

AB - Black salve is a topical escharotic used for the treatment of skin cancer. Although promoted as a safe and effective alternative to conventional management by its proponents, limited clinical research has been undertaken to assess its efficacy and potential toxicities. Patients are increasingly utilizing the Internet as a source of health information. As a minimally regulated space, the quality and accuracy of this information vary considerably. This review explores four health claims made by black salve vendors, investigating its natural therapy credentials, tumour specificity, and equivalence to orthodox medicine in relation to skin cancer cure rates and cosmesis. Based upon an analysis of in vitro constituent cytotoxicity, in vivo post black salve histology, and experience with Mohs paste, black salve is likely to possess normal tissue toxicity with some cancer cell lines being relatively resistant to its effects. This may explain the incongruous case study reports of excessive scarring, deformity, and treatment failure.

UR - http://www.scopus.com/inward/record.url?scp=85012201637&partnerID=8YFLogxK

U2 - 10.1155/2017/9184034

DO - 10.1155/2017/9184034

M3 - Review article

VL - 2017

JO - Evidence-Based Complementary and Alternative Medicine

JF - Evidence-Based Complementary and Alternative Medicine

SN - 1741-427X

M1 - 9184034

ER -