TY - GEN
T1 - A Neurocomputational Analysis Review of Dorsolateral Prefrontal Cortex rTMS Treatments of Neurological Disorder
AU - Alashwal, Hany
AU - MacIaszek, Julian
AU - Frydecka, Dorota
AU - Misiak, Blazej
AU - Moustafa, Ahmed A.
N1 - Publisher Copyright:
© 2023 ACM.
PY - 2024/3/7
Y1 - 2024/3/7
N2 - Repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) has been used as a treatment for several psychiatric and neurological disorders, including depression, bipolar disorder, anxiety, eating disorders, obsessive compulsive disorder, schizophrenia, addiction and Parkinson's disease. However, the precise mechanism of action of DLPFC rTMS and how it translates to the effectiveness of treatment of these disorders is not fully understood. In this study, we provide a review of computational explanations of how DLPFC rTMS may treat several clinical disorders. The review show that DLPFC rTMS can ameliorate several symptoms in different psychiatric and neurological disorders via the following mechanisms of action: (a) modulating the activations of several cortical and subcortical areas, (b) increasing dopamine levels in both cortical and subcortical structures, and (c) modulating connectivity among several brain areas. In addition, we discuss future directions on experimental and computational studies of DLPFC rTMS. Specifically, future computational modelling should take into account the multi-dimensional nature of DLPFC rTMS effect on the brain and behaviour.
AB - Repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) has been used as a treatment for several psychiatric and neurological disorders, including depression, bipolar disorder, anxiety, eating disorders, obsessive compulsive disorder, schizophrenia, addiction and Parkinson's disease. However, the precise mechanism of action of DLPFC rTMS and how it translates to the effectiveness of treatment of these disorders is not fully understood. In this study, we provide a review of computational explanations of how DLPFC rTMS may treat several clinical disorders. The review show that DLPFC rTMS can ameliorate several symptoms in different psychiatric and neurological disorders via the following mechanisms of action: (a) modulating the activations of several cortical and subcortical areas, (b) increasing dopamine levels in both cortical and subcortical structures, and (c) modulating connectivity among several brain areas. In addition, we discuss future directions on experimental and computational studies of DLPFC rTMS. Specifically, future computational modelling should take into account the multi-dimensional nature of DLPFC rTMS effect on the brain and behaviour.
UR - http://www.scopus.com/inward/record.url?scp=85187776076&partnerID=8YFLogxK
U2 - 10.1145/3638569.3638581
DO - 10.1145/3638569.3638581
M3 - Conference contribution
AN - SCOPUS:85187776076
T3 - ACM International Conference Proceeding Series
SP - 85
EP - 90
BT - ICCBB 2023 - Proceedings of the 2023 7th International Conference on Computational Biology and Bioinformatics
PB - Association for Computing Machinery (ACM)
T2 - 7th International Conference on Computational Biology and Bioinformatics
Y2 - 11 December 2023 through 13 December 2023
ER -