TY - JOUR
T1 - A meta-analysis of randomized controlled trials to compare long-term clinical outcomes of bioabsorbable polymer and durable polymer drug-eluting stents
AU - Mridha, Naim
AU - Subhaharan, Deloshaan
AU - Niranjan, Selvanayagam
AU - Rashid, Mohammed K.
AU - Psaltis, Peter
AU - Singh, Kuljit
N1 - Funding Information:
Future Leader Fellowship from the National Heart Foundation of Australia, and project grant funding from the National Health and Medical Research Council of Australia and NHF to P.P.
Publisher Copyright:
© Published on behalf of the European Society of Cardiology. All rights reserved.
PY - 2019/4
Y1 - 2019/4
N2 - Aims The durable polymer (DP) of a drug-eluting stent (DES) serves no function once drug elution is complete. To ascertain the benefits of bioabsorbable polymer (BP) over DP-DESs requires a longer follow-up period, to overcome the time taken for polymer absorption. The primary aim of this meta-analysis was to compare the safety and efficacy of BP-DES with the DP-DES over mid (2 years) to long-term (3-5 years) follow-up. Methods and results A thorough computer-based search was performed using Ovid MEDLINE, EMBASE, Google Scholar, and PubMed databases. We only included randomized controlled studies comparing clinical outcomes between BP-DESs and DP-DESs. Only studies where data were available for a minimum of 2 years were included. A separate analysis of 2-year outcomes and 3- to 5-year outcomes were conducted. Data from 6 and 8 studies were included in 3- to 5-year and 2-year follow-up, respectively. There were no differences between stent groups in cardiac mortality, stent thrombosis (ST), target lesion revascularization, target vessel failure, and reinfarction rates for either 2-year or 3- to 5-year follow-up. Subgroup analysis according to strut thickness (<100 μm, >100 μm) of BP-DES demonstrated similar results. The analyses of ST and very late ST favoured BP-DESs but did not reach statistically significant level. Conclusion There were no differences in clinical outcomes between BP-DESs and DP-DESs over mid- and long-term follow-up.
AB - Aims The durable polymer (DP) of a drug-eluting stent (DES) serves no function once drug elution is complete. To ascertain the benefits of bioabsorbable polymer (BP) over DP-DESs requires a longer follow-up period, to overcome the time taken for polymer absorption. The primary aim of this meta-analysis was to compare the safety and efficacy of BP-DES with the DP-DES over mid (2 years) to long-term (3-5 years) follow-up. Methods and results A thorough computer-based search was performed using Ovid MEDLINE, EMBASE, Google Scholar, and PubMed databases. We only included randomized controlled studies comparing clinical outcomes between BP-DESs and DP-DESs. Only studies where data were available for a minimum of 2 years were included. A separate analysis of 2-year outcomes and 3- to 5-year outcomes were conducted. Data from 6 and 8 studies were included in 3- to 5-year and 2-year follow-up, respectively. There were no differences between stent groups in cardiac mortality, stent thrombosis (ST), target lesion revascularization, target vessel failure, and reinfarction rates for either 2-year or 3- to 5-year follow-up. Subgroup analysis according to strut thickness (<100 μm, >100 μm) of BP-DES demonstrated similar results. The analyses of ST and very late ST favoured BP-DESs but did not reach statistically significant level. Conclusion There were no differences in clinical outcomes between BP-DESs and DP-DESs over mid- and long-term follow-up.
UR - http://www.scopus.com/inward/record.url?scp=85064138838&partnerID=8YFLogxK
U2 - 10.1093/ehjqcco/qcy036
DO - 10.1093/ehjqcco/qcy036
M3 - Article
C2 - 30032294
AN - SCOPUS:85064138838
SN - 2058-5225
VL - 5
SP - 105
EP - 113
JO - European Heart Journal - Quality of Care and Clinical Outcomes
JF - European Heart Journal - Quality of Care and Clinical Outcomes
IS - 2
ER -
