TY - JOUR
T1 - A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease
AU - Al Olama, Ali Amin
AU - Kote-Jarai, Zsofia
AU - Schumacher, Fredrick R.
AU - Wiklund, Fredrik
AU - Berndt, Sonja I.
AU - Benlloch, Sara
AU - Giles, Graham G.
AU - Severi, Gianluca
AU - Neal, David E.
AU - Hamdy, Freddie C.
AU - The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium
AU - The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons’ Section of Oncology
AU - The UK Protect Study Collaborators
AU - the Australian Prostate Cancer BioResource
AU - Donovan, Jenny L.
AU - Hunter, David J.
AU - Henderson, Brian E.
AU - Thun, Michael J.
AU - Gaziano, Michael
AU - Giovannucci, Edward L.
AU - Siddiq, Afshan
AU - Travis, Ruth C.
AU - Cox, David G.
AU - Canzian, Federico
AU - Riboli, Elio
AU - Key, Timothy J.
AU - Andriole, Gerald
AU - Albanes, Demetrius
AU - Hayes, Richard B.
AU - Schleutker, Johanna
AU - Auvinen, Anssi
AU - Tammela, Teuvo L.J.
AU - Weischer, Maren
AU - Stanford, Janet L.
AU - Ostrander, Elaine A.
AU - Cybulski, Cezary
AU - Lubinski, Jan
AU - Thibodeau, Stephen N.
AU - Schaid, Daniel J.
AU - Sorensen, Karina D.
AU - Batra, Jyotsna
AU - Clements, Judith A.
AU - Chambers, Suzanne
AU - Aitken, Joanne
AU - Gardiner, Robert A.
AU - Maier, Christiane
AU - Vogel, Walther
AU - Dörk, Thilo
AU - Brenner, Hermann
AU - Habuchi, Tomonori
AU - Ingles, Sue
AU - John, Esther M.
AU - Dickinson, Joanne L.
AU - Cannon-Albright, Lisa
AU - Teixeira, Manuel R.
AU - Kaneva, Radka
AU - Zhang, Hong Wei
AU - Lu, Yong Jie
AU - Park, Jong Y.
AU - Cooney, Kathleen A.
AU - Muir, Kenneth R.
AU - Leongamornlert, Daniel A.
AU - Saunders, Edward
AU - Tymrakiewicz, Malgorzata
AU - Mahmud, Nadiya
AU - Guy, Michelle
AU - Govindasami, Koveela
AU - O'Brien, Lynne T.
AU - Wilkinson, Rosemary A.
AU - Hall, Amanda L.
AU - Sawyer, Emma J.
AU - Dadaev, Tokhir
AU - Morrison, Jonathan
AU - Dearnaley, David P.
AU - Horwich, Alan
AU - Huddart, Robert A.
AU - Khoo, Vincent S.
AU - Parker, Christopher C.
AU - Van As, Nicholas
AU - Woodhouse, Christopher J.
AU - Thompson, Alan
AU - Dudderidge, Tim
AU - Ogden, Chris
AU - Cooper, Colin S.
AU - Lophatonanon, Artitaya
AU - Southey, Melissa C.
AU - Hopper, John L.
AU - English, Dallas
AU - Virtamo, Jarmo
AU - Marchand, Loic Le
AU - Campa, Daniele
AU - Kaaks, Rudolf
AU - Lindstrom, Sara
AU - Diver, W. Ryan
AU - Gapstur, Susan
AU - Yeager, Meredith
AU - Cox, Angela
AU - Stern, Mariana C.
AU - Corral, Roman
AU - Aly, Markus
AU - Isaacs, William
AU - Adolfsson, Jan
AU - Xu, Jianfeng
AU - Zheng, S. Lilly
PY - 2013/1/15
Y1 - 2013/1/15
N2 - Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significantSNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10-8]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.
AB - Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significantSNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10-8]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.
UR - https://www.scopus.com/pages/publications/84871603324
U2 - 10.1093/hmg/dds425
DO - 10.1093/hmg/dds425
M3 - Article
C2 - 23065704
AN - SCOPUS:84871603324
SN - 0964-6906
VL - 22
SP - 408
EP - 415
JO - Human Molecular Genetics
JF - Human Molecular Genetics
IS - 2
M1 - dds425
ER -
SDG 3 Good Health and Well-being