A DRD2 and ANKK1 haplotype is associated with nicotine dependence

Joanne Voisey, Christopher Dean Swagell, Ian Paul Hughes, Angela van Daal, Ernest Pascal Noble, Bruce Robert Lawford, Ross McDonald Young, Charles Phillip Morris

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)
47 Downloads (Pure)

Abstract

To test the importance of the dopamine D2 receptor (DRD2) region in nicotine dependence, 150 smokers and 228 controls were genotyped for the . DRD2 C957T, -141delC and . ANKK1 TaqIA polymorphisms (rs6277, rs1799732 and rs1800497, respectively). The -141delC SNP did not show any association but both the C957T and . TaqIA SNPs showed association at the allele, genotype, haplotype and combined genotype levels. The 957C/. TaqI A1 haplotype was more than 3.5 times as likely to be associated with nicotine dependence compared with the 957T/. TaqI A1 haplotype (. P=. 0.003). Analysis of the combined genotypes of both SNPs revealed that individuals who were homozygous for the 957C-allele (CC) and had either one or two copies of the . TaqI A1-allele were 3.3 times as likely to have nicotine dependence compared to all other genotype combinations (. P=. 0.0003) and that these genotypes accounted for approximately 13% of the susceptibility to nicotine addiction in our population. Our findings suggest that the . DRD2 C957T polymorphism and the . ANKK1 TaqIA polymorphism are key contributors to the genetic susceptibility to nicotine dependence.

Original languageEnglish
Pages (from-to)285-289
Number of pages5
JournalPsychiatry Research
Volume196
Issue number2-3
DOIs
Publication statusPublished - 30 Apr 2012

Fingerprint

Tobacco Use Disorder
Haplotypes
Genotype
Single Nucleotide Polymorphism
Alleles
Dopamine D2 Receptors
Genetic Predisposition to Disease
Nicotine
Population

Cite this

Voisey, J., Swagell, C. D., Hughes, I. P., van Daal, A., Noble, E. P., Lawford, B. R., ... Morris, C. P. (2012). A DRD2 and ANKK1 haplotype is associated with nicotine dependence. Psychiatry Research, 196(2-3), 285-289. https://doi.org/10.1016/j.psychres.2011.09.024
Voisey, Joanne ; Swagell, Christopher Dean ; Hughes, Ian Paul ; van Daal, Angela ; Noble, Ernest Pascal ; Lawford, Bruce Robert ; Young, Ross McDonald ; Morris, Charles Phillip. / A DRD2 and ANKK1 haplotype is associated with nicotine dependence. In: Psychiatry Research. 2012 ; Vol. 196, No. 2-3. pp. 285-289.
@article{6d2f63106b5b4b4c94eeebace5ef0dca,
title = "A DRD2 and ANKK1 haplotype is associated with nicotine dependence",
abstract = "To test the importance of the dopamine D2 receptor (DRD2) region in nicotine dependence, 150 smokers and 228 controls were genotyped for the . DRD2 C957T, -141delC and . ANKK1 TaqIA polymorphisms (rs6277, rs1799732 and rs1800497, respectively). The -141delC SNP did not show any association but both the C957T and . TaqIA SNPs showed association at the allele, genotype, haplotype and combined genotype levels. The 957C/. TaqI A1 haplotype was more than 3.5 times as likely to be associated with nicotine dependence compared with the 957T/. TaqI A1 haplotype (. P=. 0.003). Analysis of the combined genotypes of both SNPs revealed that individuals who were homozygous for the 957C-allele (CC) and had either one or two copies of the . TaqI A1-allele were 3.3 times as likely to have nicotine dependence compared to all other genotype combinations (. P=. 0.0003) and that these genotypes accounted for approximately 13{\%} of the susceptibility to nicotine addiction in our population. Our findings suggest that the . DRD2 C957T polymorphism and the . ANKK1 TaqIA polymorphism are key contributors to the genetic susceptibility to nicotine dependence.",
author = "Joanne Voisey and Swagell, {Christopher Dean} and Hughes, {Ian Paul} and {van Daal}, Angela and Noble, {Ernest Pascal} and Lawford, {Bruce Robert} and Young, {Ross McDonald} and Morris, {Charles Phillip}",
year = "2012",
month = "4",
day = "30",
doi = "10.1016/j.psychres.2011.09.024",
language = "English",
volume = "196",
pages = "285--289",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier",
number = "2-3",

}

Voisey, J, Swagell, CD, Hughes, IP, van Daal, A, Noble, EP, Lawford, BR, Young, RM & Morris, CP 2012, 'A DRD2 and ANKK1 haplotype is associated with nicotine dependence' Psychiatry Research, vol. 196, no. 2-3, pp. 285-289. https://doi.org/10.1016/j.psychres.2011.09.024

A DRD2 and ANKK1 haplotype is associated with nicotine dependence. / Voisey, Joanne; Swagell, Christopher Dean; Hughes, Ian Paul; van Daal, Angela; Noble, Ernest Pascal; Lawford, Bruce Robert; Young, Ross McDonald; Morris, Charles Phillip.

In: Psychiatry Research, Vol. 196, No. 2-3, 30.04.2012, p. 285-289.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - A DRD2 and ANKK1 haplotype is associated with nicotine dependence

AU - Voisey, Joanne

AU - Swagell, Christopher Dean

AU - Hughes, Ian Paul

AU - van Daal, Angela

AU - Noble, Ernest Pascal

AU - Lawford, Bruce Robert

AU - Young, Ross McDonald

AU - Morris, Charles Phillip

PY - 2012/4/30

Y1 - 2012/4/30

N2 - To test the importance of the dopamine D2 receptor (DRD2) region in nicotine dependence, 150 smokers and 228 controls were genotyped for the . DRD2 C957T, -141delC and . ANKK1 TaqIA polymorphisms (rs6277, rs1799732 and rs1800497, respectively). The -141delC SNP did not show any association but both the C957T and . TaqIA SNPs showed association at the allele, genotype, haplotype and combined genotype levels. The 957C/. TaqI A1 haplotype was more than 3.5 times as likely to be associated with nicotine dependence compared with the 957T/. TaqI A1 haplotype (. P=. 0.003). Analysis of the combined genotypes of both SNPs revealed that individuals who were homozygous for the 957C-allele (CC) and had either one or two copies of the . TaqI A1-allele were 3.3 times as likely to have nicotine dependence compared to all other genotype combinations (. P=. 0.0003) and that these genotypes accounted for approximately 13% of the susceptibility to nicotine addiction in our population. Our findings suggest that the . DRD2 C957T polymorphism and the . ANKK1 TaqIA polymorphism are key contributors to the genetic susceptibility to nicotine dependence.

AB - To test the importance of the dopamine D2 receptor (DRD2) region in nicotine dependence, 150 smokers and 228 controls were genotyped for the . DRD2 C957T, -141delC and . ANKK1 TaqIA polymorphisms (rs6277, rs1799732 and rs1800497, respectively). The -141delC SNP did not show any association but both the C957T and . TaqIA SNPs showed association at the allele, genotype, haplotype and combined genotype levels. The 957C/. TaqI A1 haplotype was more than 3.5 times as likely to be associated with nicotine dependence compared with the 957T/. TaqI A1 haplotype (. P=. 0.003). Analysis of the combined genotypes of both SNPs revealed that individuals who were homozygous for the 957C-allele (CC) and had either one or two copies of the . TaqI A1-allele were 3.3 times as likely to have nicotine dependence compared to all other genotype combinations (. P=. 0.0003) and that these genotypes accounted for approximately 13% of the susceptibility to nicotine addiction in our population. Our findings suggest that the . DRD2 C957T polymorphism and the . ANKK1 TaqIA polymorphism are key contributors to the genetic susceptibility to nicotine dependence.

UR - http://www.scopus.com/inward/record.url?scp=84861459614&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2011.09.024

DO - 10.1016/j.psychres.2011.09.024

M3 - Article

VL - 196

SP - 285

EP - 289

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 2-3

ER -

Voisey J, Swagell CD, Hughes IP, van Daal A, Noble EP, Lawford BR et al. A DRD2 and ANKK1 haplotype is associated with nicotine dependence. Psychiatry Research. 2012 Apr 30;196(2-3):285-289. https://doi.org/10.1016/j.psychres.2011.09.024