A central role for toll-like 4 (TLR4) receptors in interstitial cystitis?

Research output: Contribution to journalArticle

Abstract

[Extract]
Interstitial cystitis/bladder pain syndrome (IC/BPS) remains a clinical enigma. Estimated to affect over 8 million women globally, it is a challenge to diagnose and to treat effectively, due to an unknown etiology and complex, poorly understood pathophysiology. Clinical diagnosis is symptom-based, with patients experiencing debilitating chronic pelvic or bladder pain, pressure or discomfort, along with urinary storage symptoms including frequency and urgency. IC/BPS is also associated with depression and anxiety.
LanguageEnglish
JournalAmerican Journal of Physiology - Renal Physiology
DOIs
Publication statusE-pub ahead of print - 27 Jun 2018

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Interstitial Cystitis
Toll-Like Receptor 4
Urinary Bladder
Pain
Anxiety
Depression
Pressure

Cite this

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title = "A central role for toll-like 4 (TLR4) receptors in interstitial cystitis?",
abstract = "[Extract] Interstitial cystitis/bladder pain syndrome (IC/BPS) remains a clinical enigma. Estimated to affect over 8 million women globally, it is a challenge to diagnose and to treat effectively, due to an unknown etiology and complex, poorly understood pathophysiology. Clinical diagnosis is symptom-based, with patients experiencing debilitating chronic pelvic or bladder pain, pressure or discomfort, along with urinary storage symptoms including frequency and urgency. IC/BPS is also associated with depression and anxiety.",
author = "Sellers, {Donna Jayne} and Catherine McDermott and Russ Chess-Williams",
year = "2018",
month = "6",
day = "27",
doi = "10.1152/ajprenal.00290.2018",
language = "English",
journal = "American Journal of Physiology - Renal Physiology",
issn = "1522-1466",
publisher = "American Physiological Society",

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AU - Sellers, Donna Jayne

AU - McDermott, Catherine

AU - Chess-Williams, Russ

PY - 2018/6/27

Y1 - 2018/6/27

N2 - [Extract] Interstitial cystitis/bladder pain syndrome (IC/BPS) remains a clinical enigma. Estimated to affect over 8 million women globally, it is a challenge to diagnose and to treat effectively, due to an unknown etiology and complex, poorly understood pathophysiology. Clinical diagnosis is symptom-based, with patients experiencing debilitating chronic pelvic or bladder pain, pressure or discomfort, along with urinary storage symptoms including frequency and urgency. IC/BPS is also associated with depression and anxiety.

AB - [Extract] Interstitial cystitis/bladder pain syndrome (IC/BPS) remains a clinical enigma. Estimated to affect over 8 million women globally, it is a challenge to diagnose and to treat effectively, due to an unknown etiology and complex, poorly understood pathophysiology. Clinical diagnosis is symptom-based, with patients experiencing debilitating chronic pelvic or bladder pain, pressure or discomfort, along with urinary storage symptoms including frequency and urgency. IC/BPS is also associated with depression and anxiety.

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M3 - Article

JO - American Journal of Physiology - Renal Physiology

T2 - American Journal of Physiology - Renal Physiology

JF - American Journal of Physiology - Renal Physiology

SN - 1522-1466

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