A central role for Toll-like 4 receptors in interstitial cystitis?

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Abstract

[Extract]
Interstitial cystitis/bladder pain syndrome (IC/BPS) remains a clinical enigma. Estimated to affect over 8 million women globally, it is a challenge to diagnose and to treat effectively, due to an unknown etiology and complex, poorly understood pathophysiology. Clinical diagnosis is symptom-based, with patients experiencing debilitating chronic pelvic or bladder pain, pressure or discomfort, along with urinary storage symptoms including frequency and urgency. IC/BPS is also associated with depression and anxiety.
Original languageEnglish
Pages (from-to)F910-F912
JournalAmerican Journal of Physiology - Renal Physiology
Volume315
Issue number4
Early online date27 Jun 2018
DOIs
Publication statusPublished - 1 Oct 2018

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Interstitial Cystitis
Toll-Like Receptor 4
Urinary Bladder
Pain
Anxiety
Depression
Pressure

Cite this

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title = "A central role for Toll-like 4 receptors in interstitial cystitis?",
abstract = "[Extract] Interstitial cystitis/bladder pain syndrome (IC/BPS) remains a clinical enigma. Estimated to affect over 8 million women globally, it is a challenge to diagnose and to treat effectively, due to an unknown etiology and complex, poorly understood pathophysiology. Clinical diagnosis is symptom-based, with patients experiencing debilitating chronic pelvic or bladder pain, pressure or discomfort, along with urinary storage symptoms including frequency and urgency. IC/BPS is also associated with depression and anxiety.",
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A central role for Toll-like 4 receptors in interstitial cystitis? / Sellers, Donna Jayne; McDermott, Catherine; Chess-Williams, Russ.

In: American Journal of Physiology - Renal Physiology, Vol. 315, No. 4, 01.10.2018, p. F910-F912.

Research output: Contribution to journalArticleResearchpeer-review

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N2 - [Extract] Interstitial cystitis/bladder pain syndrome (IC/BPS) remains a clinical enigma. Estimated to affect over 8 million women globally, it is a challenge to diagnose and to treat effectively, due to an unknown etiology and complex, poorly understood pathophysiology. Clinical diagnosis is symptom-based, with patients experiencing debilitating chronic pelvic or bladder pain, pressure or discomfort, along with urinary storage symptoms including frequency and urgency. IC/BPS is also associated with depression and anxiety.

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